Ch. 14 Practice Quiz - PSY 347

Which of the following is not a characteristic of amotivational syndrome? a. Anxiety b. Lack of planning c. Decreased productivity d. Apathy

a. Anxiety

All of the following are withdrawal symptoms observed following long-term heavy marijuana use except a. increased sleep. b. a depressed mood. c. aggression. d. decreased appetite.

a. increased sleep.

Concerning the time course of THC levels and route of administration, a. plasma levels of THC peak more rapidly following injection or smoking than oral administration of the drug. b. people smoking marijuana typically reach their peak THC levels before they finish the cigarette or joint. c. oral administration of THC produces low plasma levels that drop off quickly. d. at maximum THC intoxication after smoking, brain and plasma THC levels are equilibrated.

a. plasma levels of THC peak more rapidly following injection or smoking than oral administration of the drug.

Which of the following drugs is a CB1 antagonist? a. SR 1416 b. Rimonabant c. Nabilone d. WIN 55,212-2

b. Rimonabant

Neurochemical changes associated with a marijuana abstinence syndrome include a. increased DA firing in the VTA. b. increased CRF release in the amygdala. c. decreased DA firing in the substantia nigra. d. decreased CRF release in the central nucleus.

b. increased CRF release in the amygdala.

The major psychoactive ingredient of the marijuana plant is a. cannabinol. b. ∆9-tetrahydrocannabinol. c. anandamide. d. ∆6-tetrahydrocannabinol.

b. ∆9-tetrahydrocannabinol.

The reinforcing effects of THC are dependent on _______, and involve _______. a. CB2 receptors; decreased dopamine release in the nucleus accumbens b. opioid receptors; decreased endocannabinoid release in the nucleus accumbens c. CB1 receptors; increased dopamine release in the nucleus accumbens d. opioid receptors; increased glutamate release in the prefrontal cortex

c. CB1 receptors; increased dopamine release in the nucleus accumbens

Which of the following is not an adverse reaction to marijuana? a. Anxiety or panic, especially in first time users b. Feelings of paranoia, with high doses c. Nausea and gastrointestinal upset d. Depression or dysphoria

c. Nausea and gastrointestinal upset

Animal studies of the rewarding effects of cannabinoids have a. found that THC is aversive to all species tested. b. shown that animals will self-administer the synthetic drugs WIN 55,212-2 and SR 141716A. c. demonstrated the importance of using low THC doses and pre-exposure to the drug. d. found reinforcing effects of THC in the place conditioning task but not the self-administration paradigm.

c. demonstrated the importance of using low THC doses and pre-exposure to the drug.

Oral administration of marijuana a. results in a shorter duration of action of the drug than smoking. b. yields low but consistent levels of drug in the body. c. leads to reduced blood levels due to first-pass metabolism and breakdown of the drug in the stomach. d. is an easy way to regulate the amount of drug entering the body.

c. leads to reduced blood levels due to first-pass metabolism and breakdown of the drug in the stomach.

The relationship between chronic marijuana use and educational achievement a. is most likely explained by the fact that marijuana causes cognitive deficits. b. is a correlational relationship that does not merit further study. c. may be explained by the social environment of marijuana users and their values concerning education. d. has only been measured in terms of absenteeism which probably reflects motivational variables more than academic factors.

c. may be explained by the social environment of marijuana users and their values concerning education.

Inhibition of _______ is not a possible effect of cannabinoids on the CB1 receptor. a. cAMP formation b. voltage sensitive Ca2+ channels c. the release of GABA d. K+ channel opening

d. K+ channel opening

Tolerance to THC a. is not well established in animals. b. is mainly due to metabolic tolerance in both humans and animals. c. occurs very slowly over a six week period. d. has been measured in terms of decreases in CB1 receptor densities.

d. has been measured in terms of decreases in CB1 receptor densities.

One of the most reliable physiological effects of cannabis use in humans is a. slowing of heart rate. b. decreased blood flow to the skin. c. faint pulse. d. increased hunger.

d. increased hunger.

Cannabinoids could be used therapeutically to treat all of the following except a. neuropathic pain. b. mood disorders. c. nausea. d. obesity.

d. obesity.