CYP3A4 inhibitors and inducers

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Inhibitors Mnemonic

G PACMAN

Oxcarbazepine

Inducer

Phenobarbital

Inducer

Phenytoin

Inducer

Rifampin, Rifabutin, Rifapentine

Inducer

Smoking

Inducer

St. John's Wort

Inducer

Carbamazepine

Inducer and auto-inducer

-Azole antifungals

Inhibitor

Amiodarone

Inhibitor

Cyclosporine and Cimetidine (H2RA)

Inhibitor

Grapefruit

Inhibitor

Macrolides

Inhibitor

Non-DHP CCBs (verapamil, diltiazem)

Inhibitor

Protease Inhibitors (-navirs)

Inhibitor

Inducers Mnemonic

PS PORCS


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