Difference between Class I and Class II MHC proteins
Where are Class II MHC proteins found?
Typically found only on the surfaces of APCs
Class I (endogenous antigens) can be ______ or ________
self or nonself
Specific cell type where Class II MHC proteins are found?
APC cells
Specific cell type where Class I MHC proteins are found?
All nucleated cells
What are the exogenous antigens found in Class II MHC proteins?
Antigens from outside the cell that have been engulfed by the cell that displays them
Which class is more common?
Class I MHC protein
Where are Class I MHC proteins found?
Found on virtually all body cells - except red blood cells
What are the endogenous antigens found on class I MHC proteins?
Fragments of proteins synthesized inside the cell
What does MHC stand for?
Major Histocompatibility Complex
Class II (exogenous antigens) are ALWAYS ______
Non-self, NEVER self
Specific example of cells that are class II MHC?
dendritic cells, macrophages and B cells
All antigens displayed on class I MHC proteins are _____ ________
endogenous antigens
The antigens for Class II MHC proteins are _____ _______-
exogenous antigens