Exam 2 Hematology Ch. 9 - Platelets - Quiz & Review Questions

7. What is the normal lifespan of platelets in the peripheral blood? A. 8 hours B. 1 day C. 10 days D. 100 days

10 days

5. The major cytokine responsible for regulating both megakaryocyte and platelet production is: A. TPO B. IL-11 C. SCF D. IL-6

TPO

Which of the following cytokines stimulate progenitor megakaryocytes to proliferate? IL-4 and IL-10 IL-6 and IL-11 TPO and GM-CSF EPO and M-CSF

TPO and GM-CSF

On average, how long does a platelet live in the peripheral circulation? 5 days 120 days 6 hours 10 days

10 days

What is a reasonable reference interval for platelets in the peripheral blood? A. 10-20 X 10^9/L B. 150-200 X 10^9/L C. 150-400 X 10^9/L D. 400-600 X 10^9/L

150-400 X 10^9/L

What is the typical concentration of platelets in the blood? 150−440 × 10^8/L 250−500 × 10^9/L 200−600 × 10^8/L 150−450 × 10^9/L

150−450 × 10^9/L

The normal reference interval for the mean platelet volume (MPV) is: 150−450 × 109/L 11−14 g/dL 9−11 8−12 fL

8−12 fL

Which of the following criteria describes giant platelets? >400 × 109/L in number 8−12 fL in volume >2N in chromosome number >5 mcM in size

>5 mcM in size

During what stage of megakaryocyte development are the platelets released into the circulation? At the point of proplatelet formation At the end of stage II During the cycling phase Between stages III and IV

At the point of proplatelet formation

Nuclear replication without cytoplasmic division is defined as: Asynchrony Dysmyelopoiesis Endomitosis Hematopoiesis

Endomitosis

Which of the following describes how platelet clumping artificially alters platelet parameters? Increases both the PDW and the MPV Decreases the PDW and increases the MPV Increases the PDW and decreases the MPV Decreases both the PDW and the MPV

Increases both the PDW and the MPV

The effect of thrombopoietin (TPO) on megakaryocytic cells can be described by all of the following except: Inhibit proliferation Advance the rate of maturation Promote endomitosis Increase the number in the bone marrow

Inhibit proliferation

What bone marrow cell id the precursor of platelets? A. Myeloblast B. Erythrocyte C. Endothelial cell D. Megakaryocyte

Megakaryocyte

Platelets are derived from which of the following? Lymphoblasts Monoblasts Pronormoblasts Megakaryocytes

Megakaryocytes

Increased DNA content in exact multiples that are contained within a single nuclear envelope defines cells that are: Polyploid Proliferating Apoptotic Differentiated

Polyploid

Which of the following cells is defined as cytoplasmic extensions that are released in groups and fragmented into individual platelets? Proplatelet Megakaryocyte Thrombocyte Megakaryoblast

Proplatelet

Laboratory results for a patient indicate that the platelet count is 89 × 10^9/L. What is likely to be observed in the peripheral blood for this patient if the platelet count is the result of increased physiological platelet destruction? Megathrombocytes Reticulated platelets Megakaryoblasts Megakaryocytes

Reticulated platelets

6. Endomitosis is defined as: A. Cell proliferation endogenous to the bone marrow B. Fragmentation of megakaryocyte cytoplasm to produce platelets C. Fusion of megakaryocyte progenitor cells to produce polyploidy megakaryocytes D. Rounds of DNA synthesis without nuclear division or cellular division

Rounds of DNA synthesis without nuclear division or cellular division

Which of the following best describes the normal morphology of platelets on a peripheral blood smear? A. They are larger than erythrocytes B. They are filled with azurophilic granules C. They are light blue in color without granules D. They have large nuclei

They are filled with azurophilic granules

Which of the following best describe the appearance of mature megakaryocytes in the bone marrow? A. They are large cells with scanty basophilic cytoplasm (high in N:C ratio) B. They are large cells with multiple discrete nuclei, basophilic cytoplasm C. They have abundant cytoplasm filled with azurophilic granules and a single, large, large lobulated nucleus D. They are about the size of a marrow macrophage with a high N:C ration and granular cytoplasm

They have abundant cytoplasm filled with azurophilic granules and a single, large, large lobulated nucleus