Pharm Fertility drug therapy

Which time frame represents the anticipated elimination half-life of most testosterone products?

10 to 100 minutes

A nurse is caring for a patient who has been prescribed clomiphene citrate for infertility. The patient also takes methyldopa for hypertension. Which outcome would a nurse anticipate may come from the drug interaction between methyldopa and clomiphene citrate?

Impaired fertility due to an increase in prolactin

Which description of clomiphene citrate's mechanism of action is accurate?

Inhibits estrogen receptors in the hypothalamus and pituitary gland to secrete more FSH and LH to stimulate ovulation

A nurse is caring for a patient who has been prescribed oral methyltestosterone therapy for infertility. This patient also takes warfarin and lisinopril. Which outcome and intervention are recommended to manage a potential drug interaction with methyltestosterone?

Methyltestosterone may increase the effects of warfarin; decrease the dosage of warfarin.

Which statement about the pharmacokinetic parameters of testosterone is accurate?

Testosterone undergoes hepatic metabolism and beta-oxidation.

Which administration considerations would be given to a nurse who is caring for a patient initiated on clomiphene citrate?

The dose may be taken with or without food. The maximum number of sequential cycles of clomiphene citrate is three. The initial dose of 50 mg once daily and may be increased by 50 mg/day for a second course if ovulation does not occur. Ovulation typically occurs within 5 to 10 days after the last dose, and intercourse should take place at least every other day.

Which teaching points would a nurse share with a patient who has diabetes and is initiated on a gel formulation of testosterone?

The drug can be transferred to others if is not completely dry. The patient should not abruptly discontinue therapy with testosterone. The patient should monitor his weight and report any weight gain of more than 5 lbs in a week. The patient should have his testosterone levels monitored within 2 to 4 weeks after starting the drug.

Which statements about the therapeutic use and pharmacodynamic parameters of clomiphene citrate are accurate?

The drug's elimination half-life is 5 to 7 days. Clomiphene citrate's duration of action is 30 days. The drug is indicated for use in women with persistent ovulatory dysfunction to stimulate ovulation. When administered to women with polycystic ovary syndrome (PCOS) who are on metformin, the success rate of ovulation is increased.

Which patient parameters would a nurse inquire about when a patient returns to have his testosterone levels monitored?

Weight changes Mood alterations blood glucose readings blood pressure chanfes