Skin Cancer
immunosuppressed, xeroderma pigmentosa
individuals who are _____________________ as a result of chemotherapy or organ transplantation or have ____________________ (genetic disease of DNA repair which makes ability to repair damage done by UV radiation less efficient) are at increased risk for squamous cell carcinoma
men
is melanoma more common in men or women?
basal cell carcinoma
least aggressive type of skin cancer
melanoma
least common type of skin cancer
3, 75
melanoma accounts for _____% of skin cancers, but causes more than _______% of skin cancer deaths
1:55
________ will be diagnosed with melanoma during their lifetime
90
________% of non-melanoma skin cancers are associated with exposure to UV radiation from the sun
1:5
_________ americans will develop skin cancer in the source of their lifetime
1:41, 1:61
_________ men and ________ women will develop melanoma in their life
merkel cell carcinoma
a rare skin cancer that usually appears as a flesh-colored or bluish-red nodule, often on the face, head or neck
8:10
about ________ skin cancers are basal cell carcinomas
UVA
aging ray
sebaceous carcinoma
an egressive, uncommon, cutaneous tumor arising from sebaceous glands in the skin
62,000, 8,000
approximately ______________ melanomas will be diagnosed this year with nearly ___________ resulting in death
head, neck
basal cell carcinomas usually develop on sun-exposed areas and especially on the _________ and __________
40-60
between __________% of americans who live at age 65 will have either basal cell carcinoma or squamous cell carcinoma at least once
are not
border of melanomas (ARE/ARE NOT) ___________ smooth, round and uniform as in normal nevi
UVB
burning ray
eccrine carcinoma
carcinoma of the eccrine sweat gland
merkel cell carcinoma
first sign of this skin cancer is usually a fast-growing, painless nodule on the skin; may be shiny, may appear in shades of red, blue, purple, or flesh-colored
1
in african americans, there are ____ melanoma cases for every 100,000 people
22
in caucasians, there are _____ melanoma cases for every 100,000 people
children, adults
in non-caucasians, there is a higher risk of melanoma in _____________ than ___________
asymptomatic, itching, 10mm, color, size, shape, pigmented lesion
melanoma is usually _____________ although ____________ may be an early manifestation. the majority of lesions are greater than __________ in diameter and the most important clinical signs of disease is change in _________, _________ or ___________ in a ___________________
touch
merkel cells thought to be associated with the sense of
1 million
more than ______________ skin cancers are diagnosed annually
melanoma
most aggressive type of skin cancer
skin cancer
most common form of cancer in the US
basal cell carcinoma
most commonly diagnosed skin cancer
eccrine carcinoma
rare; accounts for 1 of 13,000 specimens submitted to dermatopathology lab; only several hundred cases reported; commonly presents as wart lesion, plaques, or polypoid growths
2:10, 250,000, 2,500
squamous cell carcinoma accounts for _________ skin cancers, approximately _____________ cases per year, resulting in approximately ___________ deaths annually
1.3 million
squamous/basal cell incidence
1 billion
the total direct cost associated with treatment for non-melanoma skin cancers is more than ______________ dollars annually
11,200
total deaths from skin cancer
39, 40
until age ______, women are twice as likely to develop melanoma than men, but starting at age ______, melanoma incidence in men exceeds incidence in women
UV rays, pre-existing nevi, hereditary factors, carcinogens
4 causes/predispositions for melanoma
sebaceous carcinoma
75% arise in periocular reino; high tendency for local recurrence; often mistaken for benign entities; can be caused by radiation; can spread directly to sinuses and brain
asymmetry, border, color, diameter, elevation
ABCDE of skin cancer