ARS
Gastrointestinal syndrome
1000-5000 rad is thr dose range for what stage of manifest illness?
Hematologic syndrome
200-1000 rad is the dose range of what stage of manifest illness ?
The LD for humans is __ rad (range)
300-400 rad
The sequence of events following a whole body reception of a large dose of radiation delivered over a short period of time
Acute Radiation Syndrome (ARS)
4 signs & symptoms of the GI syndrome manifest illness
Anorexia GI tract bleeding Dehydration Electrolyte imbalance Emaciation
The most radiosensitive vital organ system ?
Blood forming structure (Red Bone marrow)
The mean survival time for the __ manifest illness is 0-3 days
CNSS
Following a whole-body dose of 5,000 rad, the __ manifest illness will occur with signs and symptoms of severe NVD, disorientation, ataxia, loss of equilibrium, conclusive seizures, and coma
Central nervous system syndrome
__ syndrome is the dose range of greater than 5,000 rad. Up to 3 days mean survival time. Prodromal signs & symptoms include loss of consciousness, loss of vision, & burning sensation in skin. Death may occur before Hematologic & GI symptoms have time to occur
Central nervous system syndrome
Dose of radiation increases, .... time of onset of signs and symptoms ___ Length of prodromal stage & latent period __ Symptoms are __ severe Chances of survival __ Mean survival time __
Decrease Decrease More severe Decrease Decrease
In __ death occurs from destruction of epithelial cells that line the GI tract
Gastrointestinal syndrome
__ syndrome has 4-10 days mean survival. Dose range of 1,000-5,000 rad. Increased sign and symptoms from Hematologic stage.
Gastrointestinal syndrome
Central nervous system syndrome
Greater than 5,000 rad is the dose range for what stage of manifest illness?
Recovery is likely after the __ manifest illness because the dose is NOT always lethal
Hematologic
Following a whole- body dose of 200 rad, the ___ manifest illness will occur with signs and symptoms including mild NVD, malaise, lethargy, leukopenia, anemia, & fever.
Hematologic syndrome
__ syndrome has 10-60 days mean survival time. Dose range of 200-1000 rad. Decrease in circulating platelets
Hematologic syndrome
3 manifest illness stages
Hematologic syndrome Gastrointestinal syndrome Central Nervous System syndrome
After suffering a whole body dose of 5,000 rad what's the likely cause of death ?
Increased intracranial pressure
After suffering a whole -body dose of 850 rad, what are likely causes of death ?
Infection Hemorrhage Electrolyte imbalance Dehydration
After suffering a whole-body dose of 500 rad what are 2 likely causes of death?
Infection or hemorrhage
Dose of radiation that will kill 50% of population in 60 days?
LD 50/60
This stage of ARS follows the prodromal stage & is the period of "apparent well being"
Latent period
_ ARS Stage is 100-5,000 rad dose range
Latent period
__ is the average time between irradiation and death
Mean Survival Time
4 signs or symptoms that characterize the prodromal stage of ARS
Nausea Vomiting Diarrhea Fatigue
Radiation lethality follows a __, __ dose response curve
Non-linear, threshold
__ stage of ARS occurs within minutes or hours after a whole body reception of 100 rad (1Gy) or more.
Prodromal
After suffering a whole- body dose of 8,000 rad, which stages of ARS may NOT occur ?
Prodromal Latent Manifest
This stage of ARS consists of acute clinical signs & symptoms occurring within hours following exposure & continuing for up to a few days
Prodromal Stage
4 stages of ARS
Prodromal Stage, Latent period, Manifest illness, Recovery or death
