ARS

Gastrointestinal syndrome

1000-5000 rad is thr dose range for what stage of manifest illness?

Hematologic syndrome

200-1000 rad is the dose range of what stage of manifest illness ?

The LD for humans is __ rad (range)

300-400 rad

The sequence of events following a whole body reception of a large dose of radiation delivered over a short period of time

Acute Radiation Syndrome (ARS)

4 signs & symptoms of the GI syndrome manifest illness

Anorexia GI tract bleeding Dehydration Electrolyte imbalance Emaciation

The most radiosensitive vital organ system ?

Blood forming structure (Red Bone marrow)

The mean survival time for the __ manifest illness is 0-3 days

CNSS

Following a whole-body dose of 5,000 rad, the __ manifest illness will occur with signs and symptoms of severe NVD, disorientation, ataxia, loss of equilibrium, conclusive seizures, and coma

Central nervous system syndrome

__ syndrome is the dose range of greater than 5,000 rad. Up to 3 days mean survival time. Prodromal signs & symptoms include loss of consciousness, loss of vision, & burning sensation in skin. Death may occur before Hematologic & GI symptoms have time to occur

Central nervous system syndrome

Dose of radiation increases, .... time of onset of signs and symptoms ___ Length of prodromal stage & latent period __ Symptoms are __ severe Chances of survival __ Mean survival time __

Decrease Decrease More severe Decrease Decrease

In __ death occurs from destruction of epithelial cells that line the GI tract

Gastrointestinal syndrome

__ syndrome has 4-10 days mean survival. Dose range of 1,000-5,000 rad. Increased sign and symptoms from Hematologic stage.

Gastrointestinal syndrome

Central nervous system syndrome

Greater than 5,000 rad is the dose range for what stage of manifest illness?

Recovery is likely after the __ manifest illness because the dose is NOT always lethal

Hematologic

Following a whole- body dose of 200 rad, the ___ manifest illness will occur with signs and symptoms including mild NVD, malaise, lethargy, leukopenia, anemia, & fever.

Hematologic syndrome

__ syndrome has 10-60 days mean survival time. Dose range of 200-1000 rad. Decrease in circulating platelets

Hematologic syndrome

3 manifest illness stages

Hematologic syndrome Gastrointestinal syndrome Central Nervous System syndrome

After suffering a whole body dose of 5,000 rad what's the likely cause of death ?

Increased intracranial pressure

After suffering a whole -body dose of 850 rad, what are likely causes of death ?

Infection Hemorrhage Electrolyte imbalance Dehydration

After suffering a whole-body dose of 500 rad what are 2 likely causes of death?

Infection or hemorrhage

Dose of radiation that will kill 50% of population in 60 days?

LD 50/60

This stage of ARS follows the prodromal stage & is the period of "apparent well being"

Latent period

_ ARS Stage is 100-5,000 rad dose range

Latent period

__ is the average time between irradiation and death

Mean Survival Time

4 signs or symptoms that characterize the prodromal stage of ARS

Nausea Vomiting Diarrhea Fatigue

Radiation lethality follows a __, __ dose response curve

Non-linear, threshold

__ stage of ARS occurs within minutes or hours after a whole body reception of 100 rad (1Gy) or more.

Prodromal

After suffering a whole- body dose of 8,000 rad, which stages of ARS may NOT occur ?

Prodromal Latent Manifest

This stage of ARS consists of acute clinical signs & symptoms occurring within hours following exposure & continuing for up to a few days

Prodromal Stage

4 stages of ARS

Prodromal Stage, Latent period, Manifest illness, Recovery or death