Chapter 6, Chapter 5, Chapter 4, Chapter 3, Chapter 2

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: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 106) Describe the three major roles of structural proteins.

: 1. connect membrane to the cytoskeleton to maintain cell shape 2. create cell junctions that hold tissues together 3. attach cells to the extracellular matrix by linking cytoskeleton fibers to extracellular collagen and other protein fibers Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 97) Name two ways the selectivity of a channel is determined.

: 1. the diameter of the central pore 2. the electrical charge of the amino acids that line the channel Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 143) You mix one liter of 300 mOsM NaCl with two liters 450 mOsM glucose. A. What is the osmolarity of the new solution? B. What is the final osmolarity of the NaCl in the new solution? C. What is the final osmolarity of glucose in the new solution? D. What is the tonicity of this new solution compared to a red blood cell with 300 mOsM nonpenetrating solute?

: A. 300 mOsM NaCl × 1 L = 300 mOsmoles NaCl. 450 mOsM glucose × 2 L = 900 mOsmoles glucose. Total solutes = 900 mOsmoles + 300 mOsmoles = 1200 mOsmoles. Total volume = 1 L + 2 L = 3 L. 1200 mOsmoles/3 L = 400 mOsM solution. B. 300 mOsmoles/3 L = 100 mOsM NaCl. C. 900 mOsmoles/3 L = 300 mOsM glucose. D. Solution is hyperosmotic. Glucose is a penetrating solute, so glucose diffuses into the cell, raising the osmolarity, causing water to diffuse into the cell. The cell swells. Thus, the solution is hypotonic. Section Title: Osmosis and Tonicity Learning Outcome: 5.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 113) Explain and distinguish between the following: A. chemical reaction equilibrium B. chemical equilibrium C. osmotic equilibrium

: A. Chemical reaction equilibrium is achieved in reversible reactions when the rate of the forward reaction equals the rate of the reverse reaction. At this state there is no net change in the concentration of reactants and products in the system. This does not mean that concentrations are equal. B. Chemical equilibrium occurs when the concentration of a particular solute in one location equals that in another. Typically the locations compared are intracellular vs. extracellular. C. Osmotic equilibrium occurs when total solute concentration is the same, though chemical disequilibrium may exist. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 5) Which of the following terms is NOT used to define the structure that separates the contents of a human cell from its surrounding medium? A) a cell wall B) a cell membrane C) plasma membrane D) plasmalemma E) All of the answers are correct.

: A Section Title: Biological Membranes Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 6) Permeability is a property of A) membranes. B) ions. C) solutes. D) solvents. E) proteins.

: A Section Title: Diffusion Learning Outcome: 5.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 117) If a 10% sucrose solution is separated from a 20% sucrose solution by a membrane impermeable to sucrose, in which direction will net movement of water occur? A) from the 10% sucrose solution to the 20% sucrose solution only B) from the 20% sucrose solution to the 10% sucrose solution only C) There will be no net movement of water in this case. D) from the 10% sucrose solution to the 20% sucrose solution and from the 20% sucrose solution to the 10% sucrose solution E) None of the answers are correct.

: A Section Title: Diffusion Learning Outcome: 5.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 3) According to the second law of thermodynamics, A) the amount of entropy in living systems increases without the input of energy. B) entropy decreases in living systems that are not receiving energy. C) energy can be converted, but not be created nor destroyed. D) the total amount of energy in the universe never changes.

: A Section Title: Energy in Biological Systems Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 59) carbonic anhydrase

: A Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 10) When a chemical reaction is in equilibrium, A) there is no net change in the amount of substrates or products. B) the reaction is proceeding at its maximum rate. C) the reaction has stopped. D) there are equivalent amounts of substrates and products.

: A Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 8) Isozymes A) are enzymes with slightly different structure that catalyze the same reaction. B) are enzymes with the same structure that catalyze different reactions. C) are inorganic molecules that bind to and thereby activate enzymes. D) are the inactive form of an enzyme.

: A Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 9) Enzymes increase reaction rate by A) lowering the activation energy of a reaction. B) increasing the free energy in the products. C) raising the activation energy of a reaction. D) converting an endergonic reaction to an exergonic reaction.

: A Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 97) The rate of product formation by an enzyme-catalyzed reaction would be increased by A) adding more substrate molecules. B) adding more product molecules. C) reducing the number of enzymes. D) reducing the number of substrate molecules.

: A Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 38) An example of transamination is A) removing an amine group from one molecule and binding it to a different molecule. B) removing an amino group and putting it into the bloodstream for the kidneys to discard. C) removing a phosphate group from a molecule. D) finding a brand new sports car in your driveway with your name on it.

: A Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 20) An enzyme that adds or subtracts water molecules is a A) hydrolase. B) lipase. C) transferase. D) ligase. E) kinase.

: A Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 52) dehydrogenase

: A Section Title: Enzymes Learning Outcome: 4.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 60) Homeostatic control that takes place at the tissue or cell by using paracrine or autocrine signals is called ________. A) local control B) reflex control C) Cannon's law D) down-regulation

: A Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 21) the minimum stimulus to trigger a response

: A Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 16) The thickest protein fibers from the following group are A) microtubules. B) neurofilaments. C) microfilaments. D) myosin molecules. E) keratin filaments.

: A Section Title: Intracellular Compartments Learning Outcome: 3.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 34) The number of mitochondria in skeletal muscle cells is ________ adipose (fat) cells. A) greater than B) less than C) equal to

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 35) The control center for cellular operations is the A) nucleus. B) mitochondria. C) Golgi complex. D) endoplasmic reticulum. E) ribosomes.

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 28) Which of the following consists of a network of intracellular membranes with attached ribosomes? A) rough endoplasmic reticulum B) smooth endoplasmic reticulum C) mitochondria D) nucleoli E) Golgi apparatus

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 33) Peroxisomes A) use an enzyme to destroy H2O2 that is toxic to the cell. B) are a type of lysosome. C) are responsible for the atrophy of unused muscles. D) are sites for synthesis of fatty acids, steroids, and phospholipids. E) All of the answers accurately describe peroxisomes.

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 15) Each of the following is an example of a nonmembranous organelle except one. Identify the exception. A) lysosome B) cilia C) centriole D) ribosome E) cytoskeleton

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 110) In a pancreatic cell producing digestive enzyme, you would expect to find an elaborate A) rough endoplasmic reticulum. B) smooth endoplasmic reticulum.

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 124) mitochondrion

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 127) endoplasmic reticulum

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) For each question, select the corresponding category: A. membranous organelle B. inclusion 123) lysosome

: A Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 41) Arrange the following events in protein secretion in the proper sequence. 1. The polypeptide chain enters the lumen of the endoplasmic reticulum. 2. A secretory vesicle is formed. 3. A transport vesicle is formed. 4. The polypeptide chain enters the lumen of the Golgi complex. A) 1, 2, 3, 4 B) 1, 3, 2, 4 C) 1, 3, 4, 2 D) 4, 3, 1, 2 E) 3, 1, 4, 2

: A Section Title: Intracellular Compartments Learning Outcome: 3.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 39) The term secretion refers to A) the process by which a cell releases a substance into the extracellular space for a particular use. B) synthesis of a protein for export from the cell. C) the manufacture and assembly of a material. D) storage of a material, until it is time for it to leave the cell. E) None of the answers describe secretion.

: A Section Title: Intracellular Compartments Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 17) An allosteric modulator binds to A) a region of the enzyme other than the active site. B) the active site. C) the substrate. D) the product. E) the surrounding tissue.

: A Section Title: Metabolism Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 107) The protein in the mitochondria that captures the kinetic energy of moving H+ ions and converts it to the stored energy of ATP is called A) ATP synthase. B) lactate dehydrogenase. C) oxidative phosphorylase. D) glucokinase.

: A Section Title: Metabolism Learning Outcome: 4.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 50) Following post-translational modification, any misfolded protein will be destroyed by A) ubiquitin. B) chaperones. C) methylation. D) ribonucleases.

: A Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 44) Transcription occurs in the ________ of the cell. A) nucleus B) cytoplasm C) Golgi apparatus D) smooth endoplasmic reticulum E) plasma membrane

: A Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 41) The TAC sequence of DNA is the ________ of a coding sequence that is preceded by the ________ that regulates transcription. A) start, promoter region B) start, intron C) stop, promoter region D) stop, intron

: A Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 114) If the enzyme RNA polymerase was completely inhibited within a cell, it could not A) form proteins. B) form complementary sequences of DNA. C) link pieces of DNA together. D) form spindle fibers. E) form a new nuclear membrane during cell division.

: A Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 110) Transcription of the DNA triplet sequence ATC yields A) UAG. B) TAG. C) UTC. D) ATC.

: A Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 41) This particle has a charge of +1 and a mass of 1.

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match each class of biomolecules to the correct statement about it. A. carbohydrates B. lipids C. proteins D. nucleotides 57) Glucose and ribose are examples; these molecules provide energy or structure.

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 40) The identity of an element can be determined by the number of ________.

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 51) C

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 52) O2

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 31) Polymers are a typical formation of ________ molecules. A) organic B) inorganic C) either organic or inorganic

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 47) phosphorus

: A Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 97) The designation Ca2+ means A) calcium has space for two more electrons. B) calcium has gained two more electrons. C) calcium has space for two more protons. D) calcium has gained two more protons.

: A Section Title: Molecules and Bonds Learning Outcome: 2.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 56) These are weak attractive forces between the nucleus of one atom and the electrons of another atom close by.

: A Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 14) The most important polar molecule is ________ because it is practically a universal solvent. A) water B) bicarbonate C) sodium chloride D) magnesium sulfate E) nucleic acid

: A Section Title: Molecules and Bonds Learning Outcome: 2.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 96) Which of the following elements combine to form nonpolar covalent bonds? A) carbon and hydrogen B) nitrogen and hydrogen C) sodium and chlorine D) hydrogen and oxygen E) carbon and chlorine

: A Section Title: Molecules and Bonds Learning Outcome: 2.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 104) Only free H+ contributes to the hydrogen ion concentration. A) True B) False

: A Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level III: Problem Solving (Bloom's Taxonomy: Application) 139) How many grams of glucose, m.w. 180 daltons, is necessary to make 1 liter of a 1.0 molar solution? A) 180 B) 360 C) 90 D) 6.02 × 1023 E) 1.0

: A Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 103) Lipids are hydrophobic, and do not usually dissolve in water. Because blood is water-based, the lipid cholesterol is combined with ________ so that it can be transported by blood. A) a hydrophilic molecule B) a hydrophobic molecule C) nothing; cholesterol is not transported in blood D) a cation E) an anion

: A Section Title: Noncovalent Interactions Learning Outcome: 2.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 76) The inside of a resting cell is slightly negative relative to the outside. This is an example of A) electrical disequilibrium. B) osmotic equilibrium. C) chemical disequilibrium. D) failed homeostasis.

: A Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 71) covalent modulator

: A Section Title: Protein Interactions Learning Outcome: 2.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 3) Cells regulate their level of activity by regulating the amount of proteins present in the cell at any given time, so an up regulation of enzymes would be expected to A) increase the level of productivity of chemical reactions that rely on them. B) decrease the level of productivity of chemical reactions that rely on them. C) increase the rate of reactions catalyzed by the enzymes. D) decrease the rate of reactions catalyzed by the enzymes. E) both decrease the level of productivity of chemical reactions that rely on them and decrease the rate of reactions catalyzed by the enzymes.

: A Section Title: Protein Interactions Learning Outcome: 2.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 62) the sequence and number of amino acids in the chain

: A Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 69) structural components

: A Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 66) keratin

: A Section Title: Protein Interactions Learning Outcome: 2.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 106) Chemical reactions that occur in the human body proceed at a faster rate due to special catalytic molecules called A) enzymes. B) cytozymes. C) cofactors. D) activators. E) None of the answers are correct.

: A Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 4) When an enzyme reaches its saturation point, A) the amount of substrate for the enzyme to act upon is very high. B) the amount of substrate for the enzyme to act upon is very low. C) the amount of product produced continues to increase. D) the amount of product produced by the enzyme decreases. E) the amount of substrate for the enzyme to act upon is very low and the amount of product produced by the enzyme decreases.

: A Section Title: Protein Interactions Learning Outcome: 2.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 29) receptors

: A Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 15) Usually, cytokine binding activates A) JAK kinase. B) tyrosine kinase. C) intrinsic transducers. D) calmodulin kinase. E) citrulline kinase.

: A Section Title: Signal Pathways Learning Outcome: 6.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 55) One intracellular calcium-binding protein is A) calmodulin. B) calcitonin. C) calcitriol. D) IP3. E) nitric oxide.

: A Section Title: Signal Pathways Learning Outcome: 6.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 52) The most important factor determining which type of receptor a signal molecule will bind to is A) the lipid solubility of the ligand. B) the size of the ligand. C) the size of the receptor molecule. D) the location of the receptor molecule.

: A Section Title: Signal Pathways Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 48) any value other than 0 mV, regardless of relationship to resting potential

: A Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 85) The cell membrane acts as a good A) electrical insulator. B) electrical conductor. C) electrical gradient. D) source of ions.

: A Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 64) The term meaning a mitotic population of cells that persists into adulthood applies to A) stem cells. B) totipotent cells. C) apoptosis. D) nurse cells. E) gametocytes.

: A Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 55) Due to the fact that they divide frequently, epithelia are prone to the genetic mutations associated with cancer. A) True B) False

: A Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 52) Glands that secrete hormones into the blood via tissue fluids are A) endocrine glands. B) mixed glands. C) exocrine glands. D) unicellular glands. E) None of the answers are correct.

: A Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 77) chondrocyte

: A Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 54) Every substance that enters or leaves the internal environment of the body must cross an epithelium. A) True B) False

: A Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 117) Close examination of an organ reveals a lining of several layers of cells. The layers do not contain any blood vessels, and one surface of the cells faces the internal cavity of the organ. This tissue is probably A) epithelium. B) muscle tissue. C) connective tissue. D) neural tissue. E) fat tissue.

: A Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 130) These thin, flattened cells allow the rapid passage of O2 and CO2 through the cells of the lungs and of certain blood vessels.

: A Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 137) cytosol

: A Section Title: Tissues of the Body Learning Outcome: 3.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 33) the movement of molecules against the concentration gradient

: A Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 32) the movement of molecules via proteins embedded in the cell membrane; requires ATP

: A Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 11) Which of the following is a way for solutes in an aqueous solution to move from an area of high solute concentration to an area of low solute concentration? A) only facilitated diffusion B) only osmosis C) only active transport D) both facilitated diffusion and osmosis E) None of the answers are correct.

: A Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 42) movement from the extracellular fluid into the lumen of an organ

: A Section Title: Transport Processes Learning Outcome: 5.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 19) Caveolae and clathrin-coated pits are both used in A) endocytosis. B) exocytosis. C) phagocytosis. D) All of the answers are correct. E) None of the answers are correct.

: A Section Title: Vesicular Transport Learning Outcome: 5.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 74) Pinocytosis and potocytosis are types of A) endocytosis. B) exocytosis. C) phagocytosis. D) endocytosis and exocytosis. E) exocytosis and phagocytosis.

: A Section Title: Vesicular Transport Learning Outcome: 5.5

: Level III: Problem Solving (Bloom's Taxonomy: Application) 121) Design an experiment to test whether molecular weight does indeed influence the rate of diffusion. Be sure to list all controlled variables.

: Answers will vary. Controlled variables may include temperature, pH, composition and volume of solvent or medium, amount of solute added. Solutes could be soluble dyes of different molecular weight, and rate of diffusion could be estimated by observing the extent of coloration around a dye crystal at specified intervals. Section Title: Diffusion Learning Outcome: 5.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 34) ________ are molecules that bind to the receptor in such a way that they block the normal ligand from binding and turning the receptor on. As a result, the signal pathway remains inactive.

: Antagonists (or Competitive inhibitors) Section Title: Modulation of Signal Pathways Learning Outcome: 6.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 3) The most significant difference between a paracrine and an autocrine is A) the cell that releases it. B) the cell that responds to it. C) the method of transport. D) the route of transport. E) There are no differences—they are the same.

: B Section Title: Cell-to-Cell Communication Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 7) A reversible reaction is one where A) there are large changes in the net free energy from substrate to product. B) there are small changes in the net free energy from substrate to product. C) there is no change in the net free energy from substrate to product. D) a reaction between products is unlikely due to the high activation energy.

: B Section Title: Chemical Reactions Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 94) An exergonic chemical reaction A) converts substrates into products that have more free energy. B) releases energy as the reaction progresses. C) requires the input of energy. D) requires an enzyme in order to overcome the activation energy.

: B Section Title: Chemical Reactions Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 5) Water is a polar molecule, yet it easily moves through the nonpolar portions of cell membranes. Which transport process is responsible? A) facilitated diffusion B) simple diffusion C) uniport D) symport E) antiport

: B Section Title: Diffusion Learning Outcome: 5.4

: Level III: Problem Solving (Bloom's Taxonomy: Application) 118) If a 10% sucrose solution is separated from a 20% sucrose solution by a membrane permeable to sucrose, in which direction will net diffusion of sucrose take place? A) from the 10% sucrose solution to the 20% sucrose solution B) from the 20% sucrose solution to the 10% sucrose solution C) There will be no diffusion in this case. D) from the 10% sucrose solution to the 20% sucrose solution and from the 20% sucrose solution E) neither from the 10% sucrose solution to the 20% sucrose solution nor from the 20% sucrose solution to the 10% sucrose solution

: B Section Title: Diffusion Learning Outcome: 5.4

: Level III: Problem Solving (Bloom's Taxonomy: Application) 119) The concentration of calcium inside a cell is 0.3%. The concentration of calcium outside the cell is 0.1%. How could the cell transport even more calcium to the inside? A) passive transport B) active transport C) osmosis D) exocytosis E) All of the answers are correct.

: B Section Title: Diffusion Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 23) Passive transport refers to a process that requires A) no energy at all. B) no cellular energy. C) no pressure gradient. D) no concentration gradient. E) no electrical gradient.

: B Section Title: Diffusion Learning Outcome: 5.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 24) Which of the following is NOT true of diffusion in the human body? A) Diffusion occurs faster at higher temperatures. B) Smaller molecules take longer to diffuse than larger ones. C) Net movement of molecules occurs until the osmolarity is equal. D) Diffusion is rapid over short distances and slower over longer distances.

: B Section Title: Diffusion Learning Outcome: 5.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 82) A cell that is permeable to Solute X is placed into solution containing a higher concentration of X. Diffusion occurs until equilibrium is attained. At this time, A) there is no further movement of Solute X across the membrane. B) there is no further change in concentration of Solute X. C) Both of the statements are correct. D) Neither of the statements is correct.

: B Section Title: Diffusion Learning Outcome: 5.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 72) Fick's law of diffusion states that the rate of diffusion across a membrane is A) proportional to surface area and membrane thickness, but inversely proportional to concentration gradient. B) proportional to concentration gradient, surface area, and membrane permeability. C) proportional to membrane permeability, but inversely proportional to concentration gradient and surface area. D) proportional to membrane thickness and surface area.

: B Section Title: Diffusion Learning Outcome: 5.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 83) Cations will ________ each other. A) attract B) repel C) not react with

: B Section Title: Diffusion Learning Outcome: 5.9

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 84) Anions will ________ each other. A) attract B) repel C) not react with

: B Section Title: Diffusion Learning Outcome: 5.9

Human Physiology: An Integrated Approach, 6e (Silverthorn) Chapter 4 Energy and Cellular Metabolism 1) Energy is defined as A) doing tasks that make you tired. B) the capacity to do work. C) the light and heat from the sun. D) using glucose to synthesize ATP.

: B Section Title: Energy in Biological Systems Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) In the reaction shown, identify the role of each of the participants. CO2 + H2O H2CO3 A. enzyme B. substrate(s) C. product(s) 58) CO2 + H2O

: B Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 22) A molecule that loses electrons during a reaction is A) reduced. B) oxidized. C) dehydrated. D) hydrated.

: B Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 54) lipase

: B Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 53) dehydratase

: B Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 12) In an epithelium, the apical membrane is also known as the ________ membrane. A) basolateral B) mucosal C) serosal D) basement E) nictitating

: B Section Title: Epithelial Transport Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 2) The space that is surrounded by the tissue wall of hollow organs is known as A) the peritoneal cavity. B) the lumen. C) the extracellular space. D) the epidural space. E) the tract.

: B Section Title: Functional Compartments of the Body Learning Outcome: 3.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 3) The lumen of a hollow organ such as the stomach is considered to be part of the ________ environment. A) internal B) external

: B Section Title: Functional Compartments of the Body Learning Outcome: 3.1

Human Physiology: An Integrated Approach, 6e (Silverthorn) Chapter 3 Compartmentation: Cells and Tissues 1) When cancer develops in one tissue and spreads to another via the blood or the lymph, the cancer is said to have undergone what process? A) differentiation B) metastasis C) cytokinesis D) mutation

: B Section Title: Functional Compartments of the Body Learning Outcome: 3.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 22) the organ or gland that performs the change

: B Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 116) When you eat a large meal and your body absorbs a lot of glucose and that makes its way to the interstitial fluid before going into the cell. 100% of the glucose should be absorbed into the cell from the interstitial fluid. Why does nearly all of the glucose enter the cell, rather than only half of it? A) It is moved by active transport. B) It is modified by the cell, so there is still more glucose on the outside of the cell than inside it. C) Insulin forces glucose into the cell against a concentration gradient. D) The cells make ATP so fast, they use up all the glucose as soon as it enters the cell.

: B Section Title: Integrated Membrane Processes: Insulin Secretion Learning Outcome: 5.14

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 30) The proteins synthesized in the rough endoplasmic reticulum are then sent to A) the smooth endoplasmic reticulum for storage. B) the Golgi complex for packaging. C) the lysosome for modification. D) the cell membrane for secretion. E) the nucleus for cellular use.

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 25) Which does NOT accurately complete the sentence? One of the major functions of both types of endoplasmic reticulum (ER) is the A) synthesis of biomolecules. B) storage of genetic material for the cell. C) transport of biomolecules. D) storage of biomolecules.

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 23) Centrioles A) function as pipelines to move fluid through the cell. B) direct the movement of DNA during cell division. C) hold the cell's ribosomes in place. D) are white blood cells out of vessels. E) provide shape and stability to a cell.

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 36) The beta cells of the pancreas produce insulin, a protein-based hormone. Which of the following organelles would be found in higher levels in the beta cells? A) mitochondria B) ribosomes C) microvilli D) lysosomes

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 118) Increasing muscle mass and decreasing fat content in your body can increase resting metabolism. Why is this? A) because doing so requires exercise and exercising burns calories B) because muscle cells have more mitochondria than fat cells, allowing for more energy to be made from sugar C) because adipocytes contain more cytoplasmic inclusions which slow down metabolism D) because fat cells have no blood supply and cannot carry nutrients to be metabolized

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 109) Examination of a sample of glandular cells reveals an extensive network of smooth endoplasmic reticulum. Which of the following would be a likely product of these cells? A) digestive enzymes B) steroid hormones C) protein (peptide) hormones D) transport proteins E) antibodies

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 125) ribosome

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 126) cilium

: B Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 16) A competitive inhibitor binds to A) a region of the enzyme other than the active site. B) the active site. C) the substrate. D) the product. E) the surrounding tissue.

: B Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 23) The active sites of enzymes are A) products of an enzymatic reaction. B) regions of an enzyme that are involved in bringing substrates together. C) bonds between the substrate and certain amino acids. D) not necessarily involved in a reaction.

: B Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 28) Compartmentation refers to A) pairing together isozymes that perform similar reactions. B) grouping related enzymes into specific organelles. C) separating substrates into chemical classes. D) dividing metabolic reactions into groups for better understanding.

: B Section Title: Metabolism Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 99) Cells normally regulate the rate of an enzymatic reaction by A) raising their temperature to 110° F. B) changing the concentration of an enzyme. C) increasing reaction rate as the concentration of product increases. D) allowing all metabolic enzymes to be found throughout the cytoplasm.

: B Section Title: Metabolism Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 101) In order to slow generation of product from a particular biochemical pathway within a cell, the intermediates formed by that pathway A) are removed from the cell more quickly. B) accumulate inside the cell. C) are rapidly converted into. D) become toxic to the cell.

: B Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 34) What is the potential yield of ATP molecules for each FADH2 molecule entering the electron transport system? A) 1 B) 1.5 C) 2 D) 2.5 E) 3

: B Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 27) When energy is released during catabolism, it is temporarily trapped in high energy bonds or electrons of certain compounds. Which of the following is NOT associated with carrying energy? A) ATP B) DNA C) NADH D) FADH2 E) NADPH

: B Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 31) In the aerobic metabolism of glucose, ________ acts as the final electron acceptor. A) water B) oxygen C) carbon dioxide D) lactate E) ATP

: B Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 35) Why is there a range of 30-32 ATP molecules produced from one glucose molecule? A) Sometimes the electron transport system is more efficient than other times. B) The NADH molecules produced during glycolysis are in the cytoplasm; occasionally, electrons are carried by the lower energy FADH2 instead of NADH. C) Individual variation is normal among cells. D) Any of these answers may work under different cellular conditions.

: B Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 102) Which of the following is a key intermediate of glucose catabolism to the citric acid cycle? A) ATP B) pyruvate C) oxygen D) lactate E) glucokinase

: B Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 42) All of the triplet codes needed to produce exactly one functional piece of RNA are found in one A) chromosome. B) gene. C) codon. D) anticodon. E) None of the answers are correct.

: B Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 39) The process of forming mRNA is called A) replication. B) transcription. C) translation. D) ribolation. E) protein synthesis.

: B Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 48) The tRNA molecule contains the three-base sequence called the A) codon. B) anticodon. C) semicodon. D) aminocodon.

: B Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 45) The enzymes that synthesize mRNA from the start codon are called A) ribonucleases. B) RNA polymerases. C) DNA polymerases. D) ATP synthases. E) lactate dehydrogenases.

: B Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 49) In the absence of a signal sequence, a newly synthesized protein localizes to the A) mitochondria. B) cytoplasm. C) peroxisome. D) nucleus. E) plasma membrane.

: B Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 112) The template strand of DNA A) is not involved in mRNA synthesis. B) serves as a guide for mRNA synthesis. C) includes the base uracil. D) is alternatively spliced to generate the exon.

: B Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 8) Down-regulation may allow a target cell to A) only increase its number of receptors for a ligand. B) only decrease its number of receptors for a ligand. C) only increase its binding affinity for a ligand. D) decrease the receptors' binding affinity and increase its number of receptors.

: B Section Title: Modulation of Signal Pathways Learning Outcome: 6.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 21) In regard to lipids, the term unsaturated refers to A) the lack of double bonds between adjacent carbon atoms in a fatty acid. B) the presence of double bonds between adjacent carbon atoms in a fatty acid. C) the ring structure of steroids. D) glycerol, which acts as an anchor for joined fatty acids. E) fats, such as butter and lard, which come from animal sources.

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 43) This particle has a neutral charge and a mass of 1.

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 49) sodium

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 60) Triglycerides and steroids are members of this group. As a class they are hydrophobic.

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 12) Which of the following are examples of cations? A) SO42- B) Ca2+ C) HPO42- D) HCO3- E) Cl-

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 8) Which of the following is a way to recognize a carbohydrate by looking at its name only? A) It always ends in -ase. B) It ends in -ose C) It begins with nucleo-. D) It begins with proteo-. E) It begins with lipo-.

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Identify each of the following as an element (A) or a compound (B). 50) CO2

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 39) Isotopes of the same element differ by having different numbers of ________.

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

Human Physiology: An Integrated Approach, 6e (Silverthorn) Chapter 2 Molecular Interactions 1) Stanley Miller set out to demonstrate an explanation for the origins of organic molecules using a combination of simple organic molecules, heat and periodic burst of electricity through the mixture, ultimately producing what kind of molecules? A) carbohydrates B) amino acids C) lipids D) glycoproteins E) nucleic acids

: B Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match each bond type with its description. A. van der Waals B. ionic C. hydrogen D. covalent 53) This results when an atom has such a strong attraction for electrons that it pulls one or more electrons completely away from another atom.

: B Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 100) A double covalent bond is formed when atoms A) share one pair of electrons (a total of two). B) share two pairs of electrons (a total of four). C) swap two pairs of electrons. D) transfer a pair of electrons from one atom to the other. E) transfer two pairs of electrons from one atom to the other.

: B Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 98) In a 5% NaCl solution, A) this means there are 5 grams of sodium chloride for every 100 mL of water. B) this means there are 5 grams of sodium chloride for every 100 mL of total solution. C) the solute is water. D) this means there are 5 grams of sodium chloride for every 100 mL of water and there are 5 grams of sodium chloride for every 100 mL of total solution. E) this means there are 5 grams of sodium chloride for every 100 mL of total solution and the solute is water.

: B Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 141) If 100 mL of water contains 5 grams of NaCl, m.w. 58.5 daltons, what is the molarity of the solution in moles/L? A) 0.05 B) 0.85 C) 2.92 D) 0.085 E) 0.25

: B Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 23) The alpha-helix and pleated sheet are examples of the ________ structure of a protein. A) primary B) secondary C) tertiary D) quaternary E) pentanary

: B Section Title: Noncovalent Interactions Learning Outcome: 2.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 34) Which of the following substances is most alkaline? A) lemon juice, pH = 2 B) urine, pH = 6 C) tomato juice, pH = 4 D) white wine, pH = 3 E) stomach secretions, pH = 1

: B Section Title: Noncovalent Interactions Learning Outcome: 2.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 35) If a substance has a pH that is less than 7, it is considered A) neutral. B) acidic. C) alkaline. D) a buffer. E) a salt.

: B Section Title: Noncovalent Interactions Learning Outcome: 2.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 105) In the equation CO2 + H2O H2CO3 H+ + HCO3-, which of these is an acid? A) HCO3- B) H2CO3 C) H2O D) CO2 E) H+

: B Section Title: Noncovalent Interactions Learning Outcome: 2.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 16) What by-product results during the production of nitric oxide? A) arginine B) citrulline C) nitric oxide synthase D) carbon monoxide E) carbon dioxide

: B Section Title: Novel Signal Molecules Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 65) Groups of tissues that carry out related functions may form structures known as A) cells. B) organs. C) organelles. D) organisms. E) impossible to tell from the information given

: B Section Title: Organs Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 79) Water will always move from ________ areas to ________ areas, if there are no impermeable barriers. A) hyperosmotic, hyposmotic B) hyposmotic, hyperosmotic C) isosmotic, hyposmotic D) hyperosmotic, isosmotic

: B Section Title: Osmosis and Tonicity Learning Outcome: 5.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 80) Substances that readily dissolve in water and do not readily dissolve in lipids are A) hydrophobic and lipophobic. B) hydrophilic and lipophobic. C) hydrophobic and lipophilic. D) hydrophilic and lipophilic.

: B Section Title: Osmosis and Tonicity Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) For the following questions, match the type of modulator with the best description below. A. involved in phosphorylation B. cannot be displaced by competition C. bind to proteins away from the active site D. reversible antagonist 70) irreversible antagonist

: B Section Title: Protein Interactions Learning Outcome: 2.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 37) Which of the following is a common feature of soluble proteins? A) structural support B) noncovalent interaction C) receptor binding D) chemical modulation E) All of the answers are correct.

: B Section Title: Protein Interactions Learning Outcome: 2.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the descriptions to the correct protein category. A. fibrous B. globular 65) soluble in water

: B Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 64) the spatial arrangement of amino acids; can be a helix or a pleated sheet

: B Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 67) disulfide bond

: B Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 68) lipid carriers

: B Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the membrane protein with its function. A. transfer signals from the extracellular environment to the cytoplasm of the cell B. form cell-to-cell connections C. bind to molecules to facilitate entry to or exit from the cell D. ligands bind to these proteins and are changed by the protein 27) structural proteins

: B Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 5) Why do some normal cells fail to respond to a chemical signal? A) Chemical signals are only delivered to specific cells. B) Some cells lack the necessary receptors. C) Some cells are completely without receptors. D) Some cells are completely without ligands. E) Signal chemicals often break down before reaching a distant target.

: B Section Title: Signal Pathways Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 11) When adenylyl cyclase is activated, A) calcium ions are released from intracellular stores. B) cAMP is formed. C) cAMP is broken down. D) protein kinases are metabolized. E) steroids are produced.

: B Section Title: Signal Pathways Learning Outcome: 6.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 17) The resting membrane potential in a typical nerve cell is approximately A) +70 mV. B) -70 mV. C) +35 mV. D) -35 mV. E) 0 mV.

: B Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 21) The ion that plays a key role in initiating electrical signals in neurons is A) K+. B) Na+. C) Cl-. D) Ca2+.

: B Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 51) Cl- enters the cell

: B Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 18) Compared to the outside surface, the inside of a resting cell membrane is A) positively charged. B) negatively charged. C) electrically neutral. D) continuously reversing its electrical charge. E) positively charged whenever the sodium-potassium pump is active.

: B Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 45) to -90 mV from resting potential

: B Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 63) The term meaning programmed cell death is A) necrosis. B) apoptosis. C) oncogenesis. D) diuresis. E) cytocide.

: B Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 122) Only totipotent stem cells are capable of producing new cells in an adult. A) True B) False

: B Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 57) The simple squamous epithelial lining of blood vessels is called A) basolateral epithelium. B) endothelium. C) luteal cells. D) the vasa recta. E) None of the answers are correct.

: B Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 70) It modifies proteins and packages them into secretory vesicles for export from the cell.

: B Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 72) contributes to the blood-brain barrier

: B Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 42) Movement of material between cells is known as the ________ pathway. A) transcellular B) paracellular C) metacellular D) transendothelial E) cisendothelial

: B Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 79) osteoclast

: B Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 114) A layer of glycoproteins and a network of fine protein filaments that prevents the movement of proteins and other large molecules from the connective tissue to epithelium describes A) interfacial canals. B) the basal lamina. C) the reticular lamina. D) areolar tissue. E) endothelium.

: B Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 129) This tissue actively and selectively regulates the exchange of nongaseous material, such as ions and nutrients, and can be regulated in response to various stimuli.

: B Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) On the row of cells indicated below, match A-E to the terms in the following question(s). Figure 3.1 133) apical surface

: B Section Title: Tissues of the Body Learning Outcome: 3.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 8) What are the two extracellular fluid compartments in the body? A) intracellular and plasma B) plasma and interstitial C) interstitial and intracellular D) plasma and the fluid portion of the blood E) None of the answers are correct.

: B Section Title: Transport Processes Learning Outcome: 5.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the transport process to its description. A. active transport B. passive transport 31) the movement of molecules from an area of high concentration to an area of low concentration

: B Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 38) conform(s) to the properties of specificity, competition, and saturation

: B Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 34) tends to create an equilibrium state

: B Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 37) a form of mediated transport

: B Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 71) A cell membrane that is selectively permeable A) randomly chooses which substances will pass through. B) can change which substances pass through by changing its lipid and protein content. C) is impermeable to all substances but water. D) will only allow substances in or out if their concentration in the cell is above or below a certain point.

: B Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the type of transport with its description. A. secretion B. paracellular transport C. transcellular transport D. absorption 39) between adjacent cells

: B Section Title: Transport Processes Learning Outcome: 5.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 7) The term cellular (metabolic) energy indicates any biological process requiring A) energy in any form. B) ATP. C) thermal energy. D) chemical energy. E) thermal energy and chemical energy.

: B Section Title: Transport Processes Learning Outcome: 5.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 6) Activation energy is A) the energy lost or gained in a reaction. B) the energy required for an endergonic reaction. C) the energy required to bring molecules into a position where they can interact. D) required to convert an endergonic reaction to an exergonic reaction.

: C Section Title: Chemical Reactions Learning Outcome: 4.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 77) Which property of diffusion best helps explain the necessity of the circulatory system in multicellular organisms? A) Molecules move from an area of higher concentration to an area of lower concentration. B) Diffusion can take place in an open system or across a partition that separates two systems. C) Diffusion is rapid over short distances but much slower over long distances. D) Diffusion rate is inversely related to molecule size.

: C Section Title: Diffusion Learning Outcome: 5.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 60) H2CO3

: C Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 11) Organic molecules that act as receptors/carriers for the cleaved portion of the substrate are A) vitamins. B) isoenzymes. C) coenzymes. D) modulators.

: C Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 12) The activity of an enzyme is changed by environmental factors such as temperature or pH; these factors are referred to as A) specificity. B) common bond. C) modulators. D) isozyme. E) product.

: C Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 96) Enzymes are often useful as diagnostic tools. How? A) Enzymes destroy pathogenic bacteria so blood levels of bacteria decline. B) Enzymes destroy damaged cells so X-rays reveal smaller body organs. C) Damaged cells release enzymes into the blood that can be detected. D) The liver releases enzymes that accumulate in the urine.

: C Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 98) Changes in environmental pH or temperature will cause the reaction rate for an enzyme to A) increase. B) decrease. C) either increase or decrease depending upon enzyme properties. D) not change.

: C Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 18) An enzyme that transfers chemical groups among substrates is a A) hydrolase. B) lipase. C) transferase. D) ligase. E) kinase.

: C Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 55) kinase

: C Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 4) The watery medium that surrounds a cell is known as A) cytosol. B) protoplasm. C) extracellular fluid. D) cytoplasm. E) plasma.

: C Section Title: Functional Compartments of the Body Learning Outcome: 3.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 17) An integrating center A) is the disturbance or change that sets the pathway in motion. B) is an electrical and/or chemical signal that travels to the effector. C) evaluates incoming signals and compares it with the setpoint. D) is the minimum stimulus that must be achieved to set the reflect response in motion.

: C Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 20) receives information about the regulated variable and initiates a response

: C Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 59) Each of the following is an example of homeostasis except one. Identify the exception. A) Increased pressure in the aorta triggers mechanisms to lower blood pressure. B) A rise in blood calcium levels triggers the release of a hormone that lowers blood calcium levels. C) A rise in estrogen during the menstrual cycle increases the number of progesterone receptors in the uterus. D) Increased blood sugar stimulates the release of a hormone from the pancreas that stimulates the liver to store blood sugar. E) A decrease in body temperature triggers a neural response that initiates physiological changes to increase body temperature.

: C Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 20) Tay-Sachs is a disease caused by having ineffective A) mitochondria. B) Golgi bodies. C) lysosomes. D) rough endoplasmic reticulum. E) smooth endoplasmic reticulum.

: C Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 27) Which of the following is NOT a molecule synthesized in the smooth endoplasmic reticulum (SER)? A) fatty acids B) steroids C) proteins D) lipids E) All are synthesized in the SER.

: C Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 31) If a cell lacked lysosomes, it would not be able to A) synthesize lipids. B) produce enzymes. C) digest cellular wastes and bacteria. D) destroy H2O2. E) transport water-soluble molecules.

: C Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 32) Which substance is responsible for activating the digestive enzymes inside lysosomes? A) air B) water C) acid D) enzymes E) base

: C Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 12) An immunoliposome is a liposome that A) suppresses the immune system. B) stimulates the immune system. C) can recognize cancer cells. D) None of the answers are correct.

: C Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 106) A flagellum moves a cell through a fluid medium. What moves the fluid medium across the surface of cells that are not free to move? A) centrioles B) thick filaments C) cilia D) ribosomes E) endoplasmic reticulum

: C Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 40) Which cellular organelle is considered the powerhouse of the cell? A) endoplasmic reticulum B) Golgi apparatus C) mitochondria D) nucleus E) ribosome

: C Section Title: Intracellular Compartments Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 24) When an enzyme is working as fast as it can because its active site is continually refilled with substrate, the condition is referred to as A) allosteric modulation. B) equilibrium. C) saturation. D) the Ricardo-Mertz phenomenon. E) specificity.

: C Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 30) The reactions of glycolysis occur in the cell's ________; the reactions of the citric acid cycle occur in the ________. A) cytoplasm, cytoplasm B) mitochondria, mitochondria C) cytoplasm, mitochondria D) mitochondria, cytoplasm

: C Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 33) For each NADH molecule that moves through the electron transport system, what is the potential yield of ATP molecules? A) 1 B) 2 C) 2.5 D) 3.5 E) 4

: C Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 104) Inside the matrix of the mitochondria, pyruvate A) is converted to acetyl CoA which requires energy from an NADH. B) gains a carbon in its conversion to acetyl CoA. C) requires the vitamin pantothenic acid for its conversion to acetyl CoA. D) is converted to lactate under anaerobic conditions.

: C Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 103) The net energy yield for the anaerobic metabolism of one glucose molecule is A) 2 ATP and 2 NADH. B) 0 ATP and 2 NADH. C) 2 ATP and 0 NADH. D) 2 ATP and 2 FADH2. E) 2 ATP, 6 NADH, and 2 FADH2.

: C Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 108) What happens to the oxygen that is metabolized within the mitochondria? A) The oxygen is converted to CO2. B) The oxygen is incorporated into organic molecules during cellular metabolism. C) The oxygen is combined with hydrogen to form water. D) The oxygen acts as a coenzyme in the production of ATP. E) The oxygen is converted to CO2 and is combined with hydrogen to form water.

: C Section Title: Metabolism Learning Outcome: 4.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 106) Oxidative phosphorylation occurs ________; the beneficial end product is ________. A) in the cytoplasm just inside the plasma membrane, H2O B) in the cytoplasm just inside the plasma membrane, ATP C) in the mitochondria due to the electron transport system, ATP D) in the mitochondria due to the electron transport system, CO2 E) twice during the citric acid cycle, ATP

: C Section Title: Metabolism Learning Outcome: 4.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 46) To activate a regulated gene, the formation of mRNA is ________ by the binding of ________ to the promoter. A) repressed, transcription factors B) repressed, translation factors C) induced, transcription factors D) induced, translation factors

: C Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 43) Information stored in the nucleus is translated into A) carbohydrates. B) lipids. C) proteins. D) phospholipids. E) None of the answers are correct.

: C Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 111) Transcription of the DNA triplet sequence CAT will bind to the tRNA bearing A) CAT. B) GTA. C) GUA. D) ATU.

: C Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 109) What is the result of alternative splicing of mRNA? A) A new gene is produced. B) The DNA is replicated. C) Isoenzymes are produced from a single gene. D) Genes are mutated. E) Proteins isomerize.

: C Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 42) This particle has a charge of -1 and a negligible mass.

: C Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 59) Composed of units called amino acids, these can be linked into chains over 100 peptides long.

: C Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 9) Which of the following is NOT considered an essential element for a living organism? A) carbon B) hydrogen C) mercury D) oxygen E) nitrogen

: C Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the symbol with the correct element: A. P B. Na C. Ca D. C E. K F. Pb 44) calcium

: C Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 109) Most of the fat found in the human body is in the form of A) steroids. B) phospholipids. C) triglycerides. D) prostaglandins. E) monoglycerides.

: C Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 108) A fatty acid that contains three double bonds in its carbon chain is said to be A) saturated. B) monounsaturated. C) polyunsaturated. D) hydrogenated. E) carboxylated.

: C Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 17) The chemical bonding behavior of an atom is directly determined by A) the number of protons. B) the number of neutrons. C) the number and arrangement of electrons. D) the size of the atom. E) the mass of the atom.

: C Section Title: Molecules and Bonds Learning Outcome: 2.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 54) These are weak attractive forces between hydrogen and certain other atoms.

: C Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 101) The term polar is used to describe molecules because A) polar covalent molecules are found in colder climates. B) polar covalent molecules were first discovered in polar bears. C) there are at least two distinct ends of the molecule regarding electron position and the resulting charge. D) there are at least two distinct ends of the molecule regarding hydrogen placement. E) such molecules are always linear in shape.

: C Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 142) How many grams of NaCl, m.w. 58.5 daltons, are the molar equivalent to 90 g of glucose (m.w. 180 daltons)? A) 0.25 B) 0.5 C) 29.25 D) 117 E) 14.6

: C Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 140) A 5 M solution of 100 mL of glucose contains how many grams of glucose, m.w. 180 daltons? A) 180 B) 360 C) 90 D) 6.02 × 1023 E) 1.0

: C Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 143) How many grams of NaCl, m.w. 58.5 daltons, are necessary to make 1 liter of 5% saline? A) 58.5 B) 1 C) 50 D) 6.02 × 1023 E) 2.9

: C Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 66) The heaviest organ in the body is the A) liver. B) brain. C) skin. D) stomach. E) urinary bladder.

: C Section Title: Organs Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 75) Sodium ions are more concentrated in the extracellular fluid than in the intracellular fluid. This is an example of A) electrical disequilibrium. B) osmotic equilibrium. C) chemical disequilibrium. D) failed homeostasis.

: C Section Title: Osmosis and Tonicity Learning Outcome: 5.1

Human Physiology: An Integrated Approach, 6e (Silverthorn) Chapter 5 Membrane Dynamics 1) Which body fluid compartment contains high levels of K+, large anions, and proteins? A) plasma only B) interstitial fluid only C) intracellular fluid only D) both plasma and intracellular fluid E) both plasma and interstitial fluid

: C Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 73) allosteric modulator

: C Section Title: Protein Interactions Learning Outcome: 2.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 63) the three-dimensional shape of an amino acid chain; can be fibrous or globular

: C Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 36) Protein specificity is A) the activation of a specific protein that is needed to perform a particular function. B) the degree to which a protein is attracted to a ligand. C) the ability of a protein to bind a certain ligand or a group of related ligands. D) the degree to which a protein-ligand complex initiates a response. E) the degree to which a protein is attracted to a ligand and the ability of a protein to bind a certain ligand or a group of related ligands.

: C Section Title: Protein Interactions Learning Outcome: 2.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 65) Which of the following is a unique characteristic of glucose as a solute in biological systems? A) It enters the interstitial fluid before going into the cell. B) It is freely penetrating and can pass in and out of the cells at any time. C) 100% of it is absorbed into the cell from the extracellular fluid. D) It is converted into dextrose inside the cell.

: C Section Title: Protein-Mediated Transport Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 30) transporters

: C Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 54) When calcium becomes available inside a cell, it comes from A) extracellular fluid only. B) intracellular storage only. C) extracellular fluid and intracellular storage. D) It is always available as a major cytosol cation.

: C Section Title: Signal Pathways Learning Outcome: 6.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 53) An ion widely important in intracellular signaling is A) sodium. B) potassium. C) calcium. D) chloride. E) cobalt.

: C Section Title: Signal Pathways Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 15) Which of the following statements about the resting membrane potential is TRUE? A) It is normally equal to zero volts. B) The inside of the membrane is positively charged compared to the outside. C) It results, in part, from the concentration gradients for Na+ and K+. D) It is due in part to the presence of extracellular proteins.

: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 52) membrane potential is 0 mV

: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 16) Voltage-gated (voltage-dependent) channels and antiport carriers are both types of A) structural proteins. B) enzymes. C) transporters. D) receptors.

: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 20) As the charge on the membrane of a typical neuron approaches 0 from -70 mV, the cell is A) only repolarizing. B) only hyperpolarizing. C) only depolarizing. D) only becoming more difficult to stimulate. E) hyperpolarizing and becoming more difficult to stimulate

: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 22) Which of the following is NOT involved in creating the resting potential of a neuron? A) diffusion of potassium ions out of the cell B) diffusion of sodium ions into the cell C) resting membrane permeability for sodium ions greater than potassium ions D) resting membrane permeability for potassium ions greater than sodium ions

: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 46) to +30 mV from resting potential

: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 74) their loss is characteristic of cancer

: C Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 121) Neurons in the CNS of the adult don't contain centrioles. What does that tell you about CNS neurons? A) They don't produce any products. B) It doesn't tell you much of anything. C) They don't replicate themselves. D) They don't carry nerve impulses.

: C Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 48) Each of the following is a primary tissue type except one. Identify the exception. A) muscle tissue B) neural tissue C) osseous tissue D) connective tissue E) epithelial tissue

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 56) The function of microvilli, often seen on the apical membrane of transporting epithelia, is to A) increase the movement of extracellular fluid. B) increase the resistance of the cell to viruses. C) increase the cell's surface area. D) increase the toughness of the cell. E) allow the cell to move through a fluid medium.

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 47) The types of junction proteins important in growth and development are A) claudins. B) occludins. C) CAMs. D) connexins. E) integrins.

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 69) It is the digestive system of a cell, degrading and/or recycling bacterial or organic components.

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 73) can be cell-matrix junctions

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 60) Cells that store fat are called A) fibroblasts. B) liposomes. C) adipocytes. D) mast cells. E) melanocytes.

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 46) Disappearance of which type of junction most likely contributes to the metastasis of cancer cells throughout the body? A) gap B) tight C) anchoring

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 50) Epithelial cells that are adapted for membrane transport of materials, such as ions and nutrients, usually have ________ on their apical surface. A) mitochondria B) cilia or flagella C) microvilli D) junctional complexes E) vesicles

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 76) fibroblast

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 120) Mature nerve and muscle cells are expected to lack which organelle(s)? A) nucleus B) endoplasmic reticulum C) centrioles D) ribosomes E) Golgi bodies

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 115) The distinguishing characteristic of connective tissue is A) that it is arranged in sheets of tissue that lie on body surfaces. B) always dividing, constantly being replaced throughout the body. C) the presence of extensive extracellular matrix containing widely scattered cells. D) the collagen fibers that offer support. E) All of these characteristics help make connective tissue unique.

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 113) You are looking at a slide of an unknown organ that has an empty lumen with stratified squamous epithelium contacting the lumen. Deep to the epithelium is a basement membrane and then two layers of smooth muscle. Which of the following organs would this most likely belong to and why? A) The intestines because they need to move food along and absorb digested products. B) The liver because it secretes enzymes and bile and needs to move them to the gallbladder. C) The esophagus because it is a passageway that needs to move but not absorb food products. D) The urinary bladder because it needs to stretch and constrict to store and eliminate urine.

: C Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 132) This tissue is composed of cells with membrane extensions that beat in a coordinated fashion to move fluid and particles across the tissue.

: C Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 135) basal lamina

: C Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 116) Which type of connective tissue does NOT fit with the typical characteristic regarding relative cell density? A) cartilage B) bone C) adipose D) blood E) dense

: C Section Title: Tissues of the Body Learning Outcome: 3.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 9) Saturation occurs when A) molecules are moved by the use of vesicles. B) the energy required to move molecules results from a high-energy bond. C) a group of carrier proteins is operating at its maximum rate. D) a preference of a carrier protein for a substance is demonstrated based on the differing affinities of the carrier for the substrates. E) a carrier molecule has the ability to transport only one molecule or a group of closely related molecules.

: C Section Title: Transport Processes Learning Outcome: 5.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the transport process to its description. A. simple diffusion B. facilitated diffusion C. both D. neither 35) the movement of molecules from an area of high concentration to an area of low concentration

: C Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 4) Bulk flow is fluid flow as a result of a(n) ________ gradient. A) concentration B) electrical C) pressure D) Two of the answers are correct. E) None of the answers are correct.

: C Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 10) The means by which a cell transports large molecules out of the cell is called A) phagocytosis. B) endocytosis. C) exocytosis. D) diffusion. E) active transport.

: C Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 3) All of the following are types of mediated transport except one. Identify the exception. A) facilitated diffusion B) primary active transport C) simple diffusion D) secondary active transport

: C Section Title: Transport Processes Learning Outcome: 5.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 78) Facilitated diffusion and active transport differ in that A) facilitated diffusion uses cell membrane proteins to move substances, whereas active transport does not. B) facilitated diffusion uses a substrate to bind to a protein carrier, whereas active transport does not. C) ATP is necessary for active transport, but not for facilitated diffusion. D) facilitated diffusion moves water across the cell membrane, whereas active transport does not. E) potential energy is required for active transport but not for facilitated diffusion.

: C Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 41) in one side of a cell and out the other

: C Section Title: Transport Processes Learning Outcome: 5.8

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 148) Write the chemical formula for the molecule drawn below. Which class of organic molecule does it belong to? Is it most likely polar or nonpolar?

: C11H12N2O2. The presence of the carboxylic acid (COOH) and amine (NH2) indicates this is an amino acid. Because of the R group structure, it is relatively nonpolar (this amino acid is tryptophan). Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 143) Carbon dioxide and water readily combine to form carbonic acid. The change in pH as the acid dissociates can be demonstrated with an indicator dye that changes color at a particular pH. In your physiology lab, you perform this experiment in two beakers containing room-temperature water and indicator, labeled as A and B. CO2 is bubbled into solutions A and B from a pressurized tank for 10 seconds. A stopwatch was used to measure how long it took for the solutions to change color. The data below were generated by the students. Student Time for reaction (seconds): Solution A Time for reaction (seconds): Solution B 1 62 1 2 58 2 3 57 3 Write the chemical equation for this reaction. Determine average values for each beaker. Explain how the reaction times differed. What may be present in beaker B that is absent from beaker A?

: CO2 + H2O → H2CO3 → H+ + HCO3- Average time for beaker A to change is 59 seconds, and for beaker B to change is 2 seconds, that is, the reaction occurred faster in solution B. For this to occur, an enzyme such as carbonic anhydrase must have been present in beaker B. Section Title: Enzymes Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 161) Nervous tissue consists of two general types of cells: nerve cells and glial cells. Glial cells are mitotic, whereas neural cells are not (excluding the small population of stem cells). Which type of cell is most likely to be involved in brain cancer, and why?

: Cancer results from uncontrolled cell division in mitotic cells. Therefore, glial cell cancers (gliomas) are the most common type of nervous system cancers, as they have the most mitotic activity. Section Title: Tissue Remodeling Learning Outcome: 3.11

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 125) What are the five ways that cells regulate flow of molecules through their metabolic pathways?

: 1. by controlling the enzyme concentration 2. by producing modulators (allosteric and covalent) 3. by using two different enzymes to catalyze reversible reaction 4. by isolating enzymes within intracellular organelles (compartments) 5. by maintaining an optimum ratio of ATP to ADP Section Title: Metabolism Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 128) Sydney Student is trying to memorize chemical structures of every compound his professor has indicated are important to the human body. Explain to him that an easier way is to memorize a few rules of chemical bonding and then figure out the structure of the important compounds, especially the simpler compounds.

: Elements combine to form molecules in predictable ways because of how the outer shell electrons combine between atoms. In most cases, the outer shell will be most stable with a total of eight electrons. This information is easily discernible from the periodic table. Therefore an atom with seven outer shell electrons, such as K, combines very readily with an atom with one outer shell electron, such as Cl; an atom with six outer shell electrons, such as Ca will combine with an atom with two outer shell electrons or with two atoms with one outer shell electron each, and so on. Examples: KCl, CaCl2, CH4. Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 93) ________ secretions are released into interstitial space to diffuse into the blood.

: Endocrine Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 124) Explain how the analogy of a ball and a hill is useful for describing the forms of energy to beginning physiology students. Use the synthesis of glucose by plants and the break down of glucose by humans as specific examples of the energy hill.

: Energy is required for a person to move a ball from a lower height to a higher one, and that the ball will automatically roll down the hill if allowed to, without further input of energy. The substrates CO2 and H2O require energy to be combined into C6H12O6; the energy of the sun provides this energy to "roll" the substrates up the energy hill as they combine. The glucose then contains the potential energy provided by the sun. When enzymes are present, the molecule easily breaks down to CO2 and H2O releasing energy that is used by the cell to perform work. Section Title: Enzymes Learning Outcome: 4.1

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 136) While every level of a protein's structure is important to the function of that protein, which level of structure is most important to the function of enzymes, and why?

: Enzymes and other globular proteins depend upon the three-dimensional shape resulting from the globular folding. Under conditions in which this shape is altered by denaturing agents such as heat, the protein ceases to function, though the primary and secondary structure may be unchanged. Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 39) Explain how epinephrine can cause intestinal blood vessels to constrict and cause skeletal muscle blood vessels to dilate.

: Epinephrine can bind to different isoforms of the adrenergic receptor. Epinephrine binds to the alpha receptor on the intestinal blood vessels and beta receptors on the skeletal muscle blood vessels (see Fig. 6.18). Section Title: Modulation of Signal Pathways Learning Outcome: 6.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Synthesis) 139) Cancer is abnormal, uncontrolled cell division. What property of epithelial tissues makes them more prone to develop this condition?

: Epithelial tissues contain a population of dividing cells, which divide at a moderate rate. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 138) What is the approximate concentration of solute present in alien blood cells?

: Equivalent osmolality to a 0.11% solution of glucose Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 92) ________ secretions are discharged onto an epithelial surface.

: Exocrine Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 48) lead

: F Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 122) True or False? Lipids contain substantially more oxygen than carbohydrate molecules. Based on your answer, what does that suggest about lipid solubility in water?

: False. Lipids contain much less oxygen than carbohydrates. Oxygen often participates in hydrogen bonding. With less oxygen, lipids are not able to hydrogen bond with water molecules and therefore are relatively insoluble in aqueous environments. Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 96) Explain the difference between Fick's law of diffusion and the flux of a molecule.

: Fick's law of diffusion determines the rate of diffusion. The flux of a molecule is the rate of diffusion per unit surface area of membrane. Fick's: Rate of diffusion = concentration gradient × membrane permeability × surface area Flux = concentration gradient × membrane permeability Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 37) The ________ link membrane receptors to either ion channels or to membrane enzymes located on the cytoplasmic face of the membrane.

: G proteins Section Title: Signal Pathways Learning Outcome: 6.3

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 74) Nobel Prizes were awarded to the discoverers of G proteins, the G protein-coupled adenylyl cyclase-cAMP system, and nitric oxide. Summarize each of these, and explain the importance of these discoveries to our understanding of signal pathways.

: G proteins are coupled to hundreds of different receptors on cells. These are receptors that bind ligands such as hormones, neurotransmitters, and molecules important in sensory systems. Activated G proteins open ion channels or alter enzyme activity. The G protein-coupled adenylyl cyclase-cAMP system was the first signal transduction pathway discovered, and therefore paved the way for our understanding of signal transduction. cAMP is the second messenger in many signaling systems. Nitric oxide functions as a neurotransmitter, neuromodulator, and paracrine important in cardiovascular regulation. Section Title: Novel Signal Molecules Learning Outcome: 6.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 138) Glucose-6-phosphate (G6P) binds to the enzyme glycogen synthase (GS), increasing the probability of enzyme-substrate binding. G6P is an example of a(n) ________. Based on its name, what do you think is the role of GS?

: G6P is an example of an allosteric modulator of GS. GS is required for the synthesis of glycogen. Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 96) ________ is a protective layer made up of mostly membrane carbohydrates.

: Glycocalyx Section Title: Biological Membranes Learning Outcome: 3.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 126) Do you know what kinds of cell markers your red blood cells have? Do you know your own blood type? How are these two pieces of information related?

: Glycoproteins and glycolipids can act as cell surface markers. On blood cells, some of these markers are designated as the blood type. The most common blood typing system is the A-B-O system, usually paired with the rh system, so your blood type may be, for example, B+ or O-. Some of this information is in Chapter 16. Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 86) ________ is the extracellular component of connective tissues.

: Ground substance / Matrix Section Title: Tissues of the Body Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 130) There are two solutions separated by a semipermeable membrane. Solution a is 0.2 M NaCl and solution b is 0.1 M CaCl2. Will there be a net flow of water across the membrane? Why or why not?

: In osmoles, solution a is 0.4 OsM and solution b is 0.3 OsM. Solution a is hyperosmotic, so there will be a net flow of water into solution a until equilibrium is established. Section Title: Protein-Mediated Transport Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 123) Carbonic acid is generated by bubbling CO2 into a beaker of water. If it took 5 minutes for this reaction to reach equilibrium, how would the results differ if the enzyme carbonic anhydrase was added to the beaker of water? Explain using the concept of the energy hill.

: In the presence of the enzyme, the reaction will occur much more rapidly thereby forming more carbonic acid. The enzyme lowers the activation energy for the reaction causing more product to be generated (i.e., carbonic acid). When the enzyme is present, the hill the ball must roll up before it can continue down the hill is lower than in the absence of the enzyme. Section Title: Enzymes Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 136) Some diseases, such as phenylketonuria, classical hemophilia, cystic fibrosis, and muscular dystrophy are a result of enzyme malfunction. Each of these diseases is inherited. Explain how there might be a relationship among these observations.

: Inheritance is determined by the message coded into DNA; a mutation relays a faulty message, which disrupts protein synthesis, resulting in either a faulty protein or complete absence of the protein. Enzymes are proteins. When the instructions for the synthesis of their structure are changed, they may not be able to perform their function, producing a disease condition. If the disease is not fatal prior to puberty and does not render its victim unable to reproduce, the faulty DNA will be copied during gametogenesis and will appear in a predictable percentage of offspring. Section Title: Metabolism Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 71) Briefly explain the effects of the hormone insulin on glucose transport. What is diabetes mellitus? How are Types I and II different? Why do insulin injections help alleviate one type but not the other?

: Insulin promotes glucose transport into most types of cells. Diabetes mellitus results when insulin regulation of blood glucose concentrations is impaired. In type I, the pancreas fails to produce insulin, whereas in type II insulin levels are normal to high, but target cells fail to respond properly. Insulin injections can successfully treat type I but not type II, because the endogenous insulin production in type II is sufficient but the response is abnormal. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 94) ________ proteins extend all the way across the cell membrane.

: Integral / Transmembrane Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 36) The nervous system has a role in preserving the "fitness" of the ________.

: Internal Environment Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 122) Cells of the intestine are very permeable to water while some cells of the kidney tubule are not at all permeable to water. Can you suggest some ways these two types of cells might be structurally different from each other?

: Kidney cells may have fewer open channels through which water can pass, and/or they may have more cholesterol in their membranes. Section Title: Diffusion Learning Outcome: 5.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 65) Describe the signal molecule derivatives of arachidonic acid.

: Leukotrienes are secreted by certain types of white blood cells and play a role in asthma and anaphylaxis. Prostanoids, including prostaglandins and thromboxanes, have a variety of target tissues and effects. Section Title: Novel Signal Molecules Learning Outcome: 6.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 85) ________ is any molecule that binds to another molecule.

: Ligand Section Title: Protein Interactions Learning Outcome: 2.9

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 63) Describe the four classes of membrane receptor molecules.

: Ligand-gated receptors are ion channels, integrins are linked to the cytoskeleton, receptor-enzymes activate intracellular enzymes, G protein-coupled receptors involve activation of G proteins. See Figure 6.3. Section Title: Signal Pathways Learning Outcome: 6.3

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 135) Proteins are described as having different levels of structure. List and distinguish between the level(s) that produce a linear shape vs. a globular shape, and explain why one of those levels can result in either a linear or globular shape.

: Linear shapes: primary, secondary, quaternary. Primary structure is simply the sequence of covalently bonded amino acids in a peptide chain. Secondary structure is further bonding between nearby amino acids in a peptide chain, with the molecule still retaining a strand-like shape. Quaternary structure can involve separate linear polypeptide chains held together in a strand. Globular shapes: tertiary and quaternary. Tertiary structure involves bonding between distant amino acids, which causes the molecule to be wadded. Quaternary structure occurs when more than one globular peptide chain bonds together. Section Title: Protein Interactions Learning Outcome: 2.10

: Level III: Problem Solving (Bloom's Taxonomy: Application) 132) Diuretics cause the kidneys to produce large amounts of urine. Unfortunately, they can also cause the loss of large quantities of K+ in the urine. What effect might prolonged use of diuretics have on nerve or muscle cells?

: Low concentrations of potassium in the blood is a condition called hypokalemia. Interstitial fluids would similarly become low in K+. As the resting potential of nerve and muscle cells depends primarily on extracellular K+ concentration, the potential would be altered. Decreased extracellular K+ would increase the concentration gradient for movement of K+ out of the cells, which would gradually hyperpolarize the potential as positive ions exit and make the cells less excitable (farther from threshold). Section Title: The Resting Membrane Potential Learning Outcome: 5.12

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 114) You are a server in a restaurant, always interested in going the extra mile for your customers. Patrick, a regular customer in your section, has ordered sweet iced tea and has an appointment in 10 minutes, so he must drink quickly then leave. The kitchen staff makes only unsweetened tea, but there are sugar packets on the tables. What should you do for Patrick to provide the best sweet tea, and what general principle of diffusion does this illustrate? (Hint: Will sugar dissolve quickly in an iced drink?)

: Make sugar syrup for Patrick by heating a small amount of water with a generous amount of sugar. The sugar diffuses through the water as it dissolves, and this will occur much quicker in warm water (diffusion rate increases with increasing temperature). Then add the syrup to his iced tea and serve. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 120) Explain how enzymes can be useful in the diagnosis of disease, giving specific examples. Is the change in enzyme concentration a direct or indirect result of the disease?

: Many enzymes are normally present in the blood in a particular range of concentrations. Alterations in these concentrations can be associated with abnormal conditions. For example, elevation in the digestive enzyme amylase, produced by the pancreas, may indicate pancreatic disease. Elevation of enzymes that normally operate inside cells can indicate tissue damage, such as the elevation of creatine kinase following myocardial infarction. Low amounts of hexosamidase A can indicate Tay-Sachs disease. In the examples given, the amylase and hexosamidase enzyme changes are direct results of the disease, whereas enzymes elevated because of tissue damage are the result of cellular damage and not a direct change in the enzyme itself. Section Title: Enzymes Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Application) 120) When the ions move across the cell membrane, an electrical potential change results. As you are probably aware, nerves trigger muscle movement. When you place your finger on a sharp object (such as a tack), you quickly draw your hand away and develop a sensation of pain. Which types of channels are operating under these conditions to allow nerve conduction and subsequent muscle movement?

: Mechanically gated (in sensory cell receptor potentials), voltage-gated (in nerve and muscle action potentials), and chemically gated (in neuromuscular synaptic transmission). Section Title: The Resting Membrane Potential Learning Outcome: 5.12

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 147) If a person who has not exercised regularly begins a consistent exercise routine, she will notice that her metabolism will seem to increase as her endurance improves. Why is this?

: Metabolism will increase with endurance because the number of mitochondria will increase with consistent exercise. The increase in mitochondria will improve endurance and increase metabolism of glucose because they will be metabolizing more glucose into ATP. Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 97) Explain the relationship between microtubules, cilia, flagella, centrioles, spindle fibers, and the centrosome.

: Microtubules are a cytoskeletal protein made of tubulin. Microtubules form a major component of the internal scaffolding of the cell. Microtubules can also be assembled into cilia and flagella, which are organelles that produce cell-generated movements, and into centrioles and spindle fibers. Centrioles produce the spindle fibers, which are responsible for changing the position of chromosomes during nuclear division. Centrioles are part of a larger structure known as the centrosome, which also includes a darkly staining material and acts as the cell's microtubule organizing center. Section Title: Biological Membranes Learning Outcome: 3.3

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 123) How are molarity and osmolarity different? What property of salts necessitates this distinction? How does this property affect the behavior of water?

: Molarity is the number of molecules per liter of solution, while osmolarity is the number of independent particles per liter. The ionization of salt in water illustrates the importance of this distinction: one mole of sodium chloride dissociates to produce a total of two moles of particles (one mole Na+ and one mole Cl-), or two osmoles. Osmosis is diffusion of water. A one molar solution of sodium chloride (two osmolar) produces higher osmotic pressure than a one molar solution of glucose, which does not dissociate. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 131) Ionic bonds are considered to be strong chemical bonds. Yet, ions dissociate in water. Explain this apparent contradiction.

: Molecules such as sodium chloride are bonded by ionic bonds. So much energy would be required to separate a molecule of NaCl into Na+ and Cl- that it is practically impossible. That is, if the sodium chloride is dry. Because water molecules have partial charges resulting from their polar covalent bonds, sodium chloride dissociates in water. This means that the ions separate and function relatively independently. An attraction between sodium and chloride still exists, however, and the dissociation can be described as an increase in bond length rather than a loss of the bond. Evaporate the water, though, and the sodium chloride crystals re-form. Section Title: Noncovalent Interactions Learning Outcome: 2.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 120) Explain the general chemical structure for monosaccharides and amino acids.

: Monosaccharides consist of carbon, hydrogen, and oxygen, in the ratio C:H:O of 1:2:1. Amino acids consist of a central carbon (CH), a carboxylic acid (COOH), an amine (NH2), and an organic side chain of variable structure (mainly a hydrocarbon chain, designated as R). Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 92) How do most polar molecules move through a cell membrane? Explain why water, a polar molecule, is able to cross the nonpolar portion of a cell membrane.

: Most polar molecules must be assisted by a protein, because the molecule will not interact with the nonpolar phospholipid tails. Examples are facilitated diffusion and active transport. Because water is very small and electrically neutral, it is able to diffuse between the phospholipid tails. Section Title: Diffusion Learning Outcome: 5.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 73) ________ generated in the ________ enter the electron transport system to generate 2.5 ATP molecules.

: NADH, mitochondria Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Synthesis) 142) Describe the two general meanings of the term membrane, as used in biology. Which usage indicates layers of cells and which indicates layers of molecules?

: Prior to the use of microscopes, membranes were simply thin, flexible layers of cells that separated large compartments or lined large cavities. When microscopic study of cells allowed visualization of the cell envelope and organelles, the term membrane was additionally applied to thin layers of molecules. Section Title: Biological Membranes Learning Outcome: 3.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 136) Refer to Table 5.1. How can you determine the osmolarity and tonicity of the alien blood and alien cells?

: Quantitative chemical analysis would determine osmolarity. To determine tonicity, drop the cells into various solutions and observe the cells' response under the microscope. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 79) The enzyme ________ and ________ ions are required for the synthesis of mRNA.

: RNA polymerase, magnesium or manganese Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 131) Once the promoter region of a gene is activated, ________ unwinds the DNA of the downstream gene and begins the process of ________. What is the molecule generated by this process? How does the cell control the amount of this molecule released from the nucleus?

: RNA polymerase, transcription The RNA polymerase transcribes a single stranded mRNA. The cell can decrease mRNA by controlling the activity of the promoter with transcription factors if the gene is not constitutively expressed. Decreases in an inducer or increases in a repressor would reduce the amount of mRNA available for release. In addition, the amount of mRNA released is also affected by the availability of interfering RNA (siRNA or miRNA). Increases in interfering RNA that can inactivate or destroy mRNA would reduce the amount of mRNA released from the nucleus. Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 68) ________ describes how much product is generated or substrate destroyed within a period of time.

: Reaction rate Section Title: Chemical Reactions Learning Outcome: 4.1

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 77) Receptors in cell signaling are not to be confused with receptors that activate a reflex arc. Explain the difference, using specific examples.

: Receptor molecules are proteins on or in cells that bind to ligands. This binding triggers a response within a cell, to the signaling chemical. For example, this is how a hormone exerts its effect on a target cell. Receptors in a reflex arc are not protein molecules but rather are entire cells, parts of cells, or multicellular structures. These receptors cause a signal to be sent to an integrating center, which may or may not then initiate a response usually involving many cells. For example, a blood pressure receptor detects a decrease in pressure, and sends a neural signal to cardiovascular integrating centers to trigger a vascular response to increase pressure. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 112) Write the five rules for osmolarity and tonicity. Are the relative osmolarity and tonicity of an extracellular solution compared to intracellular fluid always the same? If they are, explain why. If they are not, give specific examples of when they are different.

: See Tables 5.7 and 5.8 in the chapter. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 121) What are functional groups? List the most common functional groups found in biological molecules.

: Several combinations of atoms that occur repeatedly in biological molecules. See Table 2.1 in the main text. Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 29) ________ is a process by which an extracellular signal molecule, called the ________, activates a membrane receptor that in turn alters intracellular molecules, called the ________, to create a response.

: Signal transduction, first messenger, second messenger Section Title: Signal Pathways Learning Outcome: 6.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 126) After coming off a ribosome, several things can happen to the newly synthesized protein. Name three.

: The possible answers include the post-translational modifications: 1. folded into three-dimensional shapes 2. cross-linkages (disulfide bonds) between different regions of its amino acid chain 3. be cleaved into fragments 4. attach other molecules or groups (e.g., methylation) 5. assemble with other peptides (subunits) into polymeric proteins Section Title: Metabolism Learning Outcome: 4.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 137) You are a student intern in the research and development department of a pharmaceutical company. You have discovered a compound that destroys the common cold virus in cultured human cells. Chemical characterization reveals that carbon, hydrogen, and oxygen are present, in a 20:40:4 ratio of C:H:O. What chemical class is this compound? Experiments in rats show that neither oral nor injectable treatment with the compound was effective in destroying the virus. Discuss some possible reasons for this lack of effectiveness.

: The relatively low amount of oxygen and high carbon and hydrogen indicate that this compound is probably a lipid. Oral administration may result in digestion of the compound so that none is absorbed into the blood. Lipids are not highly soluble in water, and because blood is a watery medium, the injected lipid may not transport well in the blood. Also, human cells as well as the viruses may behave differently in culture compared to in a real patient. Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 95) List and briefly describe the seven categories of soluble proteins.

: The seven categories: enzymes, membrane transporters, signal molecules, receptors, binding proteins, regulatory proteins, and immunoglobulins. See the "Protein Interactions" section of the chapter. Section Title: Protein Interactions Learning Outcome: 2.8

: Level III: Problem Solving (Bloom's Taxonomy: Application) 126) Indicate the relative osmolarities of the following solutions. Solution a: 2 osmolar NaCl Solution b: 1 molar NaCl Solution c: 900 milliosmolar glucose A. a is ________ osmotic to b. D. a is ________ osmotic to c. B. b is ________ osmotic to a. E. b is ________ osmotic to c. C. c is ________ osmotic to a. F. c is ________ osmotic to b.

: This is easier to answer if all three solutions are described in equivalent terms. Solution b is 2 osmolar, because of the dissociation of sodium and chloride. Solution c is 0.9 osmolar. A. iso D. hyper B. iso E. hyper C. hypo F. hypo Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 89) Evaluate the validity of this statement: "The extracellular and intracellular fluid compartments have a stable solute composition that is in equilibrium."

: This statement is only partially true. The two compartments have stable solute compositions, but they are not in equilibrium. We use the term dynamic disequilibrium to describe this relationship. Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 68) Define tonic control and give a physiological example.

: Tonic control regulates physiological parameters in an up-down fashion. An example is the neural regulation of blood vessel diameter (see Fig. 6.15). Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 102) What makes vegetable oils with trans fats similar in structure to saturated animal fats? Which type of fat is harmful, and in what way?

: Trans fats have hydrogen atoms attached to make them more saturated and solid at room temperature, like animal fats. Both vegetable trans fats and saturated animal fats are associated with cardiovascular disease. Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 87) Explain why transporting epithelial cells are said to be polarized. What does it mean when a nerve cell is said to be polarized?

: Transport epithelia have cells that are polarized with respect to distribution of transport proteins in the apical and basolateral membranes, i.e., different types of transporters in the two membranes. Nerve cells are electrically polarized, meaning that the inside of the membrane is charged relative to the outside. Section Title: Epithelial Transport Learning Outcome: 5.11

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 93) Water can cross a cell membrane by a variety of means. List at least three. Do water molecules cross a membrane through the same molecules as other solutes? Explain. Are all cells equally permeable to water? Explain.

: Water can cross through the phospholipid molecules, through special water channels called aquaporins, and through open or leak channels (pores) that also transport ions. Water can move through pores as a solvation shell around ions or independent of ions, because the watery interstitial fluid is continuous with the watery cytosol when pores are open. Some cells are more permeable to water, especially those with less cholesterol in the membranes and those with a high density of pores. Section Title: Diffusion Learning Outcome: 5.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 133) You are helping your dad prepare food in the kitchen. Dad has a tablespoon of water in one hand and a tablespoon of vegetable oil in the other, when he trips over the rug and spills both spoons on the countertop. Dad notices that the oil forms a thin film on the countertop, whereas spilled water forms smaller, taller beads. How should you explain the different behavior of these liquids to your dad?

: Water forms beads when it strikes a nonabsorptive surface because of surface tension resulting from the hydrogen bonds between neighboring water molecules. Vegetable oil molecules are nonpolar covalent, therefore there is no hydrogen bonding between the lipid molecules and no bead formation. Section Title: Noncovalent Interactions Learning Outcome: 2.3

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 138) Describe what happens to NaCl when placed in water.

: Water molecules break the ionic bonds holding Na+ and Cl- together. Each sodium ion becomes surrounded by polar water molecules, with the electronegative ends of water molecules interacting with the ion. Each chloride ion also becomes surrounded by polar water molecules, but in this case it is the electropositive ends of the water molecules that bind to the ion. A consequence is that sodium and chloride ions can function relatively independently of each other when in solution. Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 91) Define the law of mass action.

: When a reaction is at equilibrium, the ratio of the substrates to the products is always the same because reaction rate is constant. Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 123) Explain the polar character of an ammonia molecule (NH3). What is the cause of the partial charges? What is the overall charge for NH3?

: When chemically bonded with each other, the nitrogen atom is partially negative whereas the hydrogen atoms are partially positive. The nitrogen atom in a molecule of ammonia has a stronger attraction for the electrons participating in the covalent bonds than the hydrogen atoms. The net charge on the molecule is still zero, however. Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 75) Food items are occasionally shown to offer protective effects to those who eat them. Garlic, for example, may improve heart health. The pungency of garlic is due to sulfur-containing compounds. Explain how these compounds are good candidates for garlic's heart benefits.

: When sulfur compounds are metabolized, hydrogen sulfide may be produced. This gas has recently been shown to be a signal molecule that relaxes blood vessels. Section Title: Novel Signal Molecules Learning Outcome: 6.3

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 144) Carbon dioxide and water readily combine to form carbonic acid. The change in pH as the acid dissociates can be demonstrated with an indicator dye that changes color at a particular pH. In your physiology lab, you perform this experiment in two beakers containing room-temperature water and indicator, labeled Resting and Exercise based upon the status of the student who exhaled through a straw into the solution. The Resting student had been sitting at the table for 30 minutes before exhaling while the Exercise student had just finished sprinting up the stairs to class late. A stopwatch was used to measure how long it took for the solutions to change color. The following data were generated by the students. Explain why the time required for the color to change was different between groups, using the word substrate in your answer. Student Time for reaction (seconds): Resting Time for reaction (seconds): Exercising 1 123 20 2 114 23 3 136 17

: With each breath, CO2 is present in the exhaled air. The students who exercised exhibited an elevated rate of CO2 generation by the metabolic cycle. Thus, the substrate concentration was higher for the Exercising student than the Resting student, which is why the time for the solution to change color was less. Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 50) What is an orphan receptor?

: a receptor that has no known ligand Section Title: Novel Signal Molecules Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 89) The purines found in DNA are ________ and ________.

: adenine, guanine Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 81) Ions with a negative charge are called ________.

: anions Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 76) During the synthesis of proteins, amino acids are assembled in the proper sequence because the tRNA molecules that bring them to the ribosome have a(n) ________ that is complementary to a specific codon in the mRNA.

: anticodon Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 63) Channel proteins that allow water to pass are called ________.

: aquaporins Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 74) The smallest unit of an element is a(n) ________.

: atom Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 32) If the signal molecule acts on the cell that secreted it, the chemical is called a(n) ________.

: autocrine Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 57) The membrane proteins that change shape and bind with specific molecules to transport them across the cell membrane are ________.

: carrier proteins Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 80) Ions with a positive charge are called ________.

: cations Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 91) In a chemical reaction, ________ between atoms are broken as atoms are rearranged in new combinations to form different chemical substances.

: chemical bonds Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 59) The three types of gated channels are ________, ________, and ________.

: chemically gated channels, voltage-gated channels, mechanically gated channels Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 67) The walls of the ________ separate the two extracellular fluid compartments.

: circulatory system Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 130) Vitamins are precursors for ________. Name two vitamins that are required for metabolic reactions.

: coenzymes Vitamins required for metabolic reactions include the B vitamins such as folic acid, biotin, and pantothenic acid and vitamin C. Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 79) A combination of two or more atoms that has physical and chemical properties that differ from the atoms that compose it is called a(n) ________.

: compound Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 30) A gap junction forms when opposing membrane-spanning proteins called ________ on two adjacent cells unite, creating a protein channel that is capable of opening and closing.

: connexins Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 84) Genes that are always being expressed in a cell involve promoters that are ________.

: constitutively active Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 45) When epinephrine combines with alpha adrenergic receptors on smooth muscle in intestinal blood vessels, the blood vessels ________; however, when epinephrine binds to beta-2 adrenergic receptors on certain skeletal muscle blood vessels, the vessels ________.

: constrict, dilate Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 65) Metabolic intermediates use ________ bonds to transfer energy to the high-energy bonds of ATP, NADH, FADH2 or NADPH.

: covalent Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 88) The peptide bond formed between amino acids occurs as a consequence of ________.

: dehydration synthesis Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 87) The molecule DNA contains the five-carbon sugar ________.

: deoxyribose Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 84) Cells are transformed into specialized units during ________.

: differentiation Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 28) Lipid signal molecules that act in a paracrine fashion and combine with G-protein coupled receptors include ________ and ________.

: eicosanoids, sphingolipids Section Title: Novel Signal Molecules Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 62) A pump that helps maintain an electrical gradient, such as the Na+-K+-ATPase is a(n) ________ pump.

: electrogenic Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 93) List the following in order of increasing mass: atom, molecule, proton, neutron, electron.

: electron < proton = neutron < atom < molecule Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 76) A(n) ________ is a substance that consists entirely of atoms with the same atomic number.

: element Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 63) Chemical reactions that require an input of energy are said to be ________.

: endergonic Section Title: Chemical Reactions Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 26) Before nitric oxide was identified, its action was observed in ________ and it was given the name ________.

: endothelial cells (blood vessel lining), endothelial-derived relaxing factor (EDRF) Section Title: Novel Signal Molecules Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 85) The lining of the heart and blood vessels is called ________.

: endothelium Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 66) The rates of chemical reactions that occur in the human body are controlled by a particular type of proteins called ________.

: enzymes Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 92) The reaction rates of many chemical reactions that occur in the body are controlled by special protein molecules called ________.

: enzymes Section Title: Protein Interactions Learning Outcome: 2.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 54) The membrane proteins that catalyze reactions that take place on the external or internal surface of the cell are ________.

: enzymes Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 64) Chemical reactions that release energy are said to be ________.

: exergonic Section Title: Chemical Reactions Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 87) The ________ is the portion of the mRNA that contains the coding sequence of the gene.

: exon Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 86) The ________ contains the coding sequence of the gene.

: exon Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 60) Membrane protein pores that can be opened and closed are called ________ channels.

: gated (regulated) Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 90) Structures composed of epithelial cells that produce secretions are called ________.

: glands Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 70) Glucose is phosphorylated to ________ with a phosphate from ________.

: glucose-6-phosphate, ATP Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 89) The study of tissue structure and function is called ________.

: histology Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 40) To maintain ________, the body uses a combination of simple diffusion across small distances; wide spread distribution of molecules through the circulatory system and rapid, specific delivery of messages by the nervous system.

: homeostasis Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 134) The folding of proteins occurs via the formation of weak ________ and ________ bonds between amino acids. Much stronger covalent bonds like ________ bonds can occur between ________ amino acids.

: hydrogen, ionic, disulfide, cysteine Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 117) Solutions are formed with water and ________ molecules as solutes which dissolve in them.

: hydrophilic Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 83) Molecules that readily dissolve in water are called ________.

: hydrophilic (most are also polar) Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 84) Molecules that do not dissolve in water are called ________.

: hydrophobic (most are also nonpolar) Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 75) The electron transport system is located in the ________ and includes enzymes and iron-containing proteins known as ________.

: inner mitochondrial membrane, cytochromes Section Title: Metabolism Learning Outcome: 4.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 67) A certain molecule that participates in more than one biochemical pathway and acts as a branch point for channeling substrate in one direction or another is called a ________.

: key intermediate Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 80) A molecule of ________ consists of all the codons needed to produce a specific polypeptide chain at the ribosome.

: mRNA Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 53) This type of membrane protein extends all the way through the cell membrane into both the extra- and intracellular fluids: ________.

: membrane-spanning Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 89) Protein folding can take place spontaneously or with ________.

: molecular chaperones Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 75) When two or more atoms are chemically linked, the smallest unit of the resulting material is referred to as a(n) ________.

: molecule Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 41) Most long-distance communication between cells takes place through the ________ and ________ systems with their combination of chemical and electrical signals.

: nervous, endocrine Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 33) All molecules secreted by nerve cells (neuromodulators, neurotransmitters, and neurohormones) are known as ________.

: neurocrines Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 25) A few gases are known to act as signal molecules, including ________, ________, and ________.

: nitric oxide, carbon monoxide, hydrogen sulfide Section Title: Novel Signal Molecules Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 82) The nucleus is surrounded by a(n) ________.

: nuclear envelope or double membrane Section Title: Biological Membranes Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 83) Communication between the nucleus and cytosol occurs through ________.

: nuclear pores Section Title: Biological Membranes Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 116) When a nitrogenous base is bonded to a pentose sugar and a phosphate, a ________ is formed.

: nucleotide Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 77) The center of an atom is called the ________.

: nucleus Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 64) Membrane protein pores that are essentially always open are called ________ or ________ channels.

: open, leak (either order) Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 69) The availability of ________ determines if pyruvate continues into the citric acid cycle.

: oxygen Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 115) The ________ of a solution is the negative logarithm of the hydrogen ion concentration, expressed in moles per liter of solution.

: pH Section Title: Noncovalent Interactions Learning Outcome: 2.7

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 149) What is the pH of a 0.005 M HCl solution? Assume complete dissociation.

: pH = 2.3. If pH = - log [H+] and HCl is a strong acid, we can assume complete dissociation will occur in solution. Section Title: Noncovalent Interactions Learning Outcome: 2.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 31) A chemical that is secreted by a cell to act on cells in its immediate vicinity is called a(n) ________.

: paracrine Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 118) The ________ molecules which form the bilayer region of the cell membrane exhibit hydrophilic properties on the outer surface and hydrophobic properties on the inner surface.

: phospholipid Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 72) In the process of ________ a phosphate group is attached to a molecule.

: phosphorylation Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 88) The fluid substance of blood is called ________.

: plasma Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 66) The two extracellular compartments in the body are ________ and ________.

: plasma, interstitial fluid Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 61) A molecule positioned on the high-concentration side of a concentration gradient stores ________ energy.

: potential Section Title: Energy in Biological Systems Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 74) Energy released by electrons moving through the electron transport system is stored as ________ by H+ ions concentrated in the ________.

: potential energy, intermembrane space Section Title: Metabolism Learning Outcome: 4.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 85) Transcription factors are proteins whose binding to the ________ region for a gene can ________ (increase) or ________ (decrease) expression of that gene.

: promoter, induce, repress Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 38) Many second messenger systems activate ________, enzymes that transfer a phosphate group from ATP to a protein. The phosphorylation of proteins sets off a series of intracellular events that lead to the ultimate cellular response.

: protein kinases Section Title: Signal Pathways Learning Outcome: 6.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 86) Two methods of protein activation include ________ and ________.

: proteolytic (removal of portions of the molecule), cofactor binding Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 81) Ribosomes are composed of protein and ________.

: rRNA Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 44) Homeostatic regulation usually involves a(n) ________ that is sensitive to a particular stimulus (variable) and a(n) ________ whose activity has an effect on the same stimulus.

: receptor; effector Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 55) The membrane proteins that bind to a ligand and act in the body's chemical signaling system are ________.

: receptors Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 69) At rest, nerve cells have an unequal distribution of ions on either side of the cell membrane, producing the ________.

: resting membrane potential Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 62) A chemical reaction that can proceed in both directions is called a ________.

: reversible reaction Section Title: Chemical Reactions Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 88) The molecule RNA contains the five-carbon sugar ________.

: ribose Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 80) Nucleoli function in the production of ________.

: ribosomes / rRNA Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 58) Carrier proteins operating at their maximum rate are said to be ________.

: saturated Section Title: Protein-Mediated Transport Learning Outcome: 5.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 42) An intracellular signal molecule that translates a signal from a neurotransmitter or hormone into an intracellular response is called a ________.

: second messenger Section Title: Signal Pathways Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 81) Cell membranes are said to be ________ because they allow some substances to pass but not others.

: selectively permeable Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 78) Electrons travel around the center of the atom at high speed forming a(n) ________.

: shell (or orbital) Section Title: Molecules and Bonds Learning Outcome: 2.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 43) The secretion of the hormone insulin in response to changes in blood glucose level is an example of a(n) ________ reflex.

: simple endocrine Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 82) RNA is usually ________ -stranded.

: single Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 83) Two types of RNA block translation of mRNA. They are ________ RNA and ________ RNA.

: small interfering, micro Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 82) A(n) ________ is a homogeneous mixture containing a solvent and a solute.

: solution Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 68) The ability of a carrier molecule to transport only one specific molecule or a group of closely related molecules is called ________.

: specificity Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 56) The membrane proteins that provide for support of the cell membrane and allow for cells to connect to each other are ________.

: structural proteins Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 78) Amino acids are carried to the ribosomes to be incorporated into polypeptide chains by ________.

: tRNA Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 24) Peripheral cells sensitive to the presence of hormones are called ________.

: targets Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 49) What is the half-life of a signal?

: the time required for a signal to lose half its activity Section Title: Novel Signal Molecules Learning Outcome: 6.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 90) The pyrimidines found in DNA are ________ and ________.

: thymine, cytosine Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 61) A physiological parameter which is regulated in an up-down fashion by signals that are always present but change in intensity is said to be under ________.

: tonic control Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 77) mRNA is created in a process called ________. It then leaves the ________ and enters the cytosol to direct ________, the assembly of amino acids into protein.

: transcription; nucleus, translation Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 35) If the concentration of an endocrine ligand decreases, the target cell may insert more receptors into the cell membrane in an attempt to keep its response at a normal level, in a process known as ________.

: up-regulation Section Title: Modulation of Signal Pathways Learning Outcome: 6.1

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 152) Cancer is not one disease but a group of related diseases, caused by abnormal genes, environmental factors, and/or viral infections. Describe the basic common characteristics of cancers, including the role of anchoring junctions and proteases. What is a tumor? What is metastasis? Is cancer usually considered to be contagious? Explain.

: Cancer results when cells begin to divide and grow and do not respond to normal controls that would limit their growth. Anchoring junctions eventually fail to keep the cancer cells together, allowing them to spread to other organs where they continue to grow uncontrolled. Some cancer cells secrete proteases that improve their ability to spread or metastasize. A tumor is a lump of cancerous cells. Cancer is usually not contagious, being caused instead by genetic mutations in an individual or exposure to environmental factors by that individual; exceptions are cancers caused by viruses, which are believed to be the minority. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 127) Candy bars are well known to supply large amounts of energy for metabolism. With all this energy trapped inside, how can the candy bar sit still on the shelf in the grocery store?

: Candy bars contain large amounts of energy, but it is trapped as potential energy in carbohydrates (both simple and complex). The carbohydrates must be broken down and enter the cell's metabolic pathways in order to convert the potential energy to another form. Section Title: Metabolism Learning Outcome: 4.1

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 76) "Too much of a good thing can hurt you." "It's all good." We've all heard phrases like this, and know that they contain some truth. For example, both life essentials water and sunshine can harm us. Not enough cholesterol in the body is worse than too much. What otherwise poisonous gas has recently been shown to be a signal molecule? What does it do in the body?

: Carbon monoxide is one of the gaseous signal molecules. It activates guanylyl cyclase and cGMP in smooth muscle and neural tissue. Section Title: Novel Signal Molecules Learning Outcome: 6.3

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 153) Identify the virus associated with some types of cervical cancer. How is this virus acquired? Is it accurate to consider cervical cancer to be contagious? Explain.

: Cervical cancer can be caused by the human papillomavirus, or HPV. This virus is typically acquired from sexual contact with an infected person. Given that the virus is contagious, some consider cervical cancer to be a sexually transmitted cancer. Section Title: Tissue Remodeling Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 94) Explain the differences between channel proteins and carrier proteins and why cells need both.

: Channel proteins allow more rapid transport but are not as selective. Carrier proteins are slower because of the conformation change. They are also more selective and can move larger molecules than channel proteins. Carrier proteins never allow free exchange across the membrane because they never create a continuous passage between the inside and outside of the cell. Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 129) What is chemiosmotic theory? What is its role in metabolism?

: Chemiosmotic theory is a model that explains the movement of electrons through the electron transport system. This occurs across the mitochondrial inner membrane and drives oxidative phosphorylation and production of ATP by ATP synthase. Section Title: Metabolism Learning Outcome: 4.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 100) Distinguish between the following terms: cotransport; antiport; symport.

: Cotransport is the moving of more than one kind of molecule at one time. Antiport is cotransport of two or more solutes in opposite directions across the membrane. Symport is cotransport of two or more solutes in the same direction across the membrane. Section Title: Protein-Mediated Transport Learning Outcome: 5.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 9) Which of the following is NOT a membrane lipid? A) sphingolipids B) cholesterol C) phospholipids D) All are membrane lipids.

: D Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 10) Which cellular organelle is a lipid bilayer that controls which objects can leave or enter the cell? A) endoplasmic reticulum B) Golgi apparatus C) nucleus D) plasma membrane E) ribosome

: D Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 4) Neurotransmitters and neurohormones both A) are released by neurons. B) affect only cells with a specific receptor. C) travel in the blood to their target cell. D) are released by neurons and affect only cells with specific receptors. E) are produced by all cells.

: D Section Title: Cell-to-Cell Communication Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 4) Chemical reactions in a living system function to A) only transfer energy from one molecule to another. B) create new energy. C) only use energy stored in a molecule. D) transfer energy from one molecule to another or use energy stored in a molecule.

: D Section Title: Chemical Reactions Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 5) The ________ of glycogen from many glucose molecules is an ________ reaction. A) decomposition, endergonic B) synthesis, exergonic C) decomposition, exergonic D) synthesis, endergonic

: D Section Title: Chemical Reactions Learning Outcome: 4.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 73) Which of the following would increase the rate of diffusion across a cell membrane? A) a decrease in the surface area of the membrane B) a decrease in the concentration gradient C) a decrease in membrane permeability D) a decrease in membrane thickness

: D Section Title: Diffusion Learning Outcome: 5.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 25) Which of these results in a REDUCED molecule? A) loss of phosphate B) gain of phosphate C) loss of electrons D) gain of electrons

: D Section Title: Enzyme Learning Outcome: 4.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 95) How would the lack of a required cofactor for an enzyme affect that enzyme's function? A) The enzyme's function would not be altered. B) The enzyme would function more slowly. C) The enzyme would function more quickly. D) The enzyme would not be able to function.

: D Section Title: Enzymes Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 19) An enzyme that joins two substrates using energy is a A) hydrolase. B) lipase. C) transferase. D) ligase. E) kinase.

: D Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the specific enzyme to its class. A. oxidoreductase B. hydrolase C. transferase D. ligase E. lyase 51) synthetase

: D Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 13) The addition of a phosphate group to a substrate is called ________. The enzyme that catalyzes this reaction is referred to as a ________. A) proteolysis; phosphatase B) phosphorylation; phosphatase C) proteolysis; kinase D) phosphorylation; kinase

: D Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the term with its description: A. threshold B. effector C. integrating center D. setpoint E. sensory receptor 19) the desired target value for a parameter

: D Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 105) Which of the following cytoskeleton components are responsible for the movement of chromosomes during cell division? A) microfilaments B) intermediate filaments C) thick filaments D) microtubules E) All of the answers are correct.

: D Section Title: Intracellular Compartments Learning Outcome: 3.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 108) Plasma is to blood as ________ is to cytoplasm. A) inclusion B) organelle C) protein D) cytosol E) serum

: D Section Title: Intracellular Compartments Learning Outcome: 3.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 18) Each of the following statements concerning mitochondria is TRUE except one. Identify the exception. A) The mitochondrial cristae increase the inner surface area of the organelle. B) The matrix of the mitochondria contains metabolic enzymes involved in energy production. C) Respiratory enzymes are attached to the surface of the cristae. D) The mitochondria contain no DNA or RNA. E) The mitochondria produce most of a cell's ATP.

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 26) All of the following are synthesized along various sites of the endoplasmic reticulum except one. Identify the exception. A) proteins B) fatty acids C) steroids D) RNA E) phospholipids

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 21) Microvilli are found A) mostly in muscle cells. B) on the inside of cell membranes. C) in large numbers on cells that secrete hormones. D) in cells that are actively engaged in absorption. E) only on cells lining the reproductive tract.

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the organelle with its function. A. endoplasmic reticulum B. Golgi apparatus C. lysosomes D. mitochondria E. peroxisomes 67) The "powerhouse" of the cell, ATP is produced here.

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 19) In humans, only ________ cells have flagella. A) respiratory tract lining B) intestine lining C) stomach lining D) sperm E) uterine tube lining

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 24) Most of the ATP required to power cellular operations is produced in the A) ribosomes. B) endoplasmic reticulum. C) nucleus. D) mitochondria. E) Golgi apparatus.

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 107) Which of the following statements is NOT true regarding mitochondria? A) The outer mitochondrial membrane is responsible for its shape. B) The intermembrane space is used in the production of ATP. C) Mitochondria contain their own DNA and RNA. D) Mitochondria can replicate themselves only when directed by the cell's nuclear DNA. E) Mitochondria are responsible for providing energy to the cell.

: D Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 26) End-product inhibition describes the process whereby A) decreasing amounts of substrate reduce activity of the enzyme. B) decreasing amounts of product reduce activity of the enzyme. C) increasing amounts of substrate reduce activity of the enzyme. D) increasing amounts of product reduce activity of the enzyme. E) increasing amounts of product reduce activity of all enzymes in the vicinity.

: D Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 32) The explanation for how ATP bonds are actually formed during oxidative phosphorylation is called A) the Krebs hypothesis. B) the second law of thermodynamics. C) the proton principle. D) the chemiosmotic theory. E) Murphy's law.

: D Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 29) Aerobic metabolism of glucose A) requires oxygen. B) produces more ATP per glucose than anaerobic pathways. C) is the fastest way to produce glucose. D) requires oxygen and produces more ATP per glucose than anaerobic pathways.

: D Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 105) NADH is produced from each reaction described except one. Identify the exception. A) during aerobic glycolysis B) during the conversion of pyruvate to acetyl CoA C) during the citric acid cycle D) during anaerobic glycolysis

: D Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 37) ATP synthase transfers the ________ energy of the H+ ions to the high-energy phosphate bond of ________. A) potential, NADH B) potential, ATP C) kinetic, NADH D) kinetic, ATP E) None of the answers are correct.

: D Section Title: Metabolism Learning Outcome: 4.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 40) After forming a complex with the ribosome, mRNA interacts with a third molecule. This molecule is called A) DNA. B) an amino acid. C) rRNA. D) tRNA. E) rough ER.

: D Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 47) Once synthesized, the ________ of mRNA are removed through ________, which results in the formation of the coding sequence of a protein. A) exon, RNA interference B) exon, alternative splicing C) intron, RNA interference D) intron, alternative splicing

: D Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 100) Increasing ________ will decrease the amount of mRNA transcript within a cell for a constitutively active gene. A) ribonuclease activity only B) RNA polymerase activity only C) siRNA concentration only D) ribonuclease activity and siRNA concentration only E) ribonuclease activity, RNA polymerase activity and siRNA concentration

: D Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 113) During starvation, steroid hormones trigger the transcription of genes for lipid metabolism in their target cells. This would be an example of control by A) negative feedback. B) positive feedback. C) repressors. D) inducers. E) alternative splicing.

: D Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 32) Cholesterol is A) a precursor to steroid hormones. B) a structural component of cell membranes. C) a dangerous fat that is absent from a healthy body. D) a precursor to steroid hormones and a structural component of cell membranes. E) a precursor to steroid hormones, a structural component of cell membranes, and a dangerous fat that is absent from a healthy body.

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 2) Glycosylated molecules are those formed with which group of organic compounds? A) lipids B) nucleic acids C) proteins D) carbohydrates E) lipoproteins

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 22) Each amino acid differs from others in the A) number of central carbon atoms. B) size of the amino group. C) number of carboxyl groups. D) chemical structure of the R group. E) number of peptide bonds in the molecule.

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 27) A nucleotide consists of a A) five-carbon sugar and phosphate group. B) five-carbon sugar and a nitrogenous base. C) phosphate group and a nitrogenous base. D) five-carbon sugar, a nitrogenous base, and a phosphate group. E) five-carbon sugar and an amino acid.

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 58) ATP and DNA are examples; they transfer energy and encode genetic information.

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 29) The most important energy-transferring compound in cells is a nucleotide known as A) glucose. B) fructose. C) protein. D) adenosine triphosphate. E) deoxyribonucleic acid.

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 30) Which bases below are purines? 1. adenine 2. cytosine 3. guanine 4. thymine 5. uracil A) 1 and 2 B) 2 and 3 C) 1, 3, and 5 D) 1 and 3 E) 2, 4, and 5

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 45) carbon

: D Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 13) A positively charged ion is called a(n) A) electron. B) proton. C) neutron. D) cation. E) anion.

: D Section Title: Molecules and Bonds Learning Outcome: 2.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 19) The weak interactions between atoms that keep atoms near each other but don't tightly bind them together are called A) hydrogen bonds. B) van der Waals forces. C) ionic bonds. D) hydrogen bonds and van der Waals forces. E) van der Waals forces and ionic bonds.

: D Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 55) These result when two atoms share a pair of electrons.

: D Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 15) A molecule referred to as highly soluble is A) very likely to dissolve in water. B) not very likely to dissolve in water. C) called aqueous. D) very likely to dissolve in water and is called aqueous. E) not very likely to dissolve in water and is called aqueous.

: D Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 25) The concentration of a solution expresses the amount of A) solvent per volume of solute. B) solute per volume of solvent. C) solvent per volume of solution. D) solute per volume of solution. E) None of the answers are correct.

: D Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 24) Interactions between different globular or fibrous polypeptide chains result in which type of structure? A) primary B) secondary C) tertiary D) quaternary E) pentagonal

: D Section Title: Noncovalent Interactions Learning Outcome: 2.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 33) A component of an important buffer in the human body is A) NaCl. B) H+. C) HCl. D) HCO3-. E) H2O.

: D Section Title: Noncovalent Interactions Learning Outcome: 2.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 36) the use of ATP to move molecules

: D Section Title: Osmosis and Tonicity Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 72) competitive inhibitor

: D Section Title: Protein Interactions Learning Outcome: 2.10

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 111) If a polypeptide contains 10 peptide bonds, how many amino acids does it contain? A) 0 B) 5 C) 10 D) 11 E) 12

: D Section Title: Protein Interactions Learning Outcome: 2.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match each level of protein structure with its description. A. primary B. secondary C. tertiary D. quaternary 61) applies to proteins containing more than one peptide chain

: D Section Title: Protein Interactions Learning Outcome: 2.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 110) Each of the following is a function of proteins except one. Identify the exception. A) support and structure B) transport C) catalyst D) storage of genetic information E) carrying of messages

: D Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 28) enzymes

: D Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 7) Chromium is A) a major essential element. B) a minor essential element. C) a dietary supplement with no natural role in the body. D) None of the answers are correct.

: D Section Title: Running Problem Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 6) Receptor molecules on the surface of a cell A) determine that cell's response. B) may allow a particular ligand to bind. C) bind to all ligands. D) determine that cell's response and may allow a particular ligand to bind. E) determine that cell's response and bind to all ligands.

: D Section Title: Signal Pathways Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 10) Lipophilic hormones A) bind to receptors on the surface of the cell. B) function by way of a second messenger system. C) cannot diffuse through the cell membrane. D) bind to receptors inside the cytoplasm or nucleus. E) function by activating cAMP.

: D Section Title: Signal Pathways Learning Outcome: 6.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 9) Inositol triphosphate A) is a water-insoluble messenger molecule. B) binds to the calcium channel of the endoplasmic recticulum. C) is involved in the release of calcium into the cytosol. D) is a second messenger that is involved in the release of calcium into the cytosol. E) uses all of the mechanisms.

: D Section Title: Signal Pathways Learning Outcome: 6.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 57) The binding of lipophilic messengers, such as steroid hormones, to their receptors triggers A) adenylyl cyclase activation. B) cyclic nucleotide formation. C) G protein inhibition. D) gene transcription. E) protein kinase activation.

: D Section Title: Signal Pathways Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 13) Cyclic AMP activates A) a G protein. B) adenylyl cyclase. C) protein hormones. D) protein kinase A. E) hormone receptors.

: D Section Title: Signal Pathways Learning Outcome: 6.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 51) The intracellular effector in chemical signaling is often A) a hormone. B) a membrane receptor molecule. C) ATP. D) a protein kinase. E) cholesterol.

: D Section Title: Signal Pathways Learning Outcome: 6.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 25) Gated channels for sodium ions may include A) mechanical gates, which respond to pressure. B) chemical gates, which respond to ligands. C) voltage gates, which respond to electrical signals. D) All of the answers are correct. E) None of the answers are correct.

: D Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 26) When a neuron changes its ion permeability from the resting state, A) a variety of gated ion channels may open or close. B) Na+ channels may open, allowing Na+ to enter the cell. C) K+ channels must open, allowing K+ to enter the cell. D) only a variety of gated ion channels may open or close and Na+ channels may open, allowing Na+ to enter the cell. E) a variety of gated ion channels may open or close, Na+ channels may open, allowing Na+ to enter the cell, and K+ channels must open, allowing K+ to enter the cell.

: D Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 44) to -70 mV from -50 mV

: D Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 47) to -70 mV from -90 mV

: D Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 111) Chondrocytes are to cartilage as osteocytes are to A) blood. B) epithelium. C) fat. D) bone. E) neural tissue.

: D Section Title: Tissues of the Body Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) Match the cell type to its tissue or function. A. cartilage B. destroys bone matrix C. loose connective tissue D. fat E. maintains bone matrix 75) adipocyte

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 43) All but one of the structures listed below are a type of cell junction. Identify the exception. A) desmosomes B) tight junctions C) gap junctions D) loose junctions E) adherens junctions

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 49) Functions of epithelia include all of the following EXCEPT A) providing physical protection. B) controlling permeability. C) producing specialized secretions. D) storing energy reserves. E) movement.

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 61) Loose connective tissue functions in A) supporting small glands. B) supporting epithelia. C) anchoring blood vessels and nerves. D) All of the answers are correct.

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 112) The tissue(s) that is/are considered excitable because of the ability to generate electrical signals is/are called A) muscle tissue. B) neural tissue. C) epithelial tissue. D) muscle tissue and neural tissue. E) muscle tissue, neural tissue, and epithelial tissue.

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 45) The type of protein found in gap junctions is the A) claudin. B) occludin. C) cadherin. D) connexin. E) integrin.

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 119) Microscopic examination of a tissue reveals an open framework of fibers with a large volume of fluid ground substance and elastic fibers. This tissue would most likely have come from the A) inner wall of a blood vessel. B) lungs. C) spleen. D) tissue that separates skin from underlying muscle. E) bony socket of the eye.

: D Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 44) The esophagus is a tube that carries food from the mouth to the stomach. It does not secrete any enzymes or absorb any nutrients, but it does need to stand up to significant friction and stress. The type of epithelium most likely lining the esophagus would be: A) cuboidal epithelium. B) simple squamous epithelium. C) simple columnar epithelium. D) stratified squamous epithelium. E) transitional epithelium.

: D Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 136) plasma membrane

: D Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) The five functional types of epithelia are listed below. Match each type with its location and/or description. A. exchange B. transport C. ciliated D. protective E. secretory 128) Found in the epidermis, esophagus, and mouth, these stacked layers of cells prevent exchange, while they resist chemicals, bacteria, and other destructive forces.

: D Section Title: Tissues of the Body Learning Outcome: 3.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 13) Hyposmotic solutions A) have higher concentrations of solutes than hyperosmotic solutions. B) have lower concentrations of solutes than other hyposmotic solutions. C) have the same concentration of solutes as hyperosmotic solutions. D) have lower concentrations of solutes than hyperosmotic solutions. E) None of the answers are correct.

: D Section Title: Transport Processes Learning Outcome: 5.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 14) Which of the following statements about the Na+/K+ pump is FALSE? A) It transports Na+ out of the cell and K+ into the cell. B) It is present in neurons. C) Its activity requires the expenditure of metabolic (cellular) energy. D) It transports Na+ and K+ in a 1:1 ratio.

: D Section Title: Transport Processes Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 40) from an organ's lumen to the extracellular fluid

: D Section Title: Transport Processes Learning Outcome: 5.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 115) Regulatory-protein transcription factors bind to ________ and activate ________, which tells the RNA polymerase ________.

: DNA, promoter, where to bind to the DNA Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 128) A certain reaction pathway consists of four steps. How would decreasing the amount of enzyme that catalyzes the second step affect the process?

: Decreasing the amount of enzyme at the second step would slow down the whole series of reactions because less product would be available as substrate for the next two steps. The net result would be a decrease in the rate of production of the product and therefore, within a specified time, a decrease in the amount of the product. Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 11) A liposome is A) only an additive to creams and lotions. B) only a drug-delivery vehicle. C) only a type of lipid. D) only a structural component of cell membranes. E) an additive to creams and lotions and a drug-delivery vehicle.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 14) The cellular organelle(s) responsible for packaging and transporting proteins is/are the A) microtubules. B) mitochondria. C) rough endoplasmic reticulum. D) ribosomes. E) Golgi complex.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 68) These degrade long chain fatty acids and toxic foreign molecules.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 13) Intermediate filaments A) provide the cell with strength. B) stabilize the position of organelles. C) transport materials within the cytoplasm. D) form the neurofilaments in nerve cells. E) All of the answers are correct.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 37) If the adrenal cortex produces lipid based hormones such as aldosterone, which organelle would be higher in cells of the adrenal cortex than in the adrenal medulla? A) Golgi apparatus B) mitochondria C) ribosome D) rough endoplasmic reticulum E) smooth endoplasmic reticulum

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 38) The nucleus stores all the information needed to synthesize which of the following molecules? A) carbohydrates B) lipids C) proteins D) phospholipids E) All of the answers are correct.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 15) When an enzyme's activity is destroyed by heat or a change in pH, the enzyme is said to be A) broken. B) toxic. C) conjugated. D) tertiary. E) denatured.

: E Section Title: Metabolism Learning Outcome: 4.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 36) Which can serve as substrates for ATP production? A) glucose only B) amino acids only C) fatty acids only D) glucose and fatty acids only E) glucose, amino acids and fatty acids

: E Section Title: Metabolism Learning Outcome: 4.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 56) Signal molecule receptors exhibit A) specificity only. B) competition only. C) saturation only. D) competition and saturation only. E) specificity, competition, and saturation.

: E Section Title: Modulation of Signal Pathways Learning Outcome: 6.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 5) Which group of elements makes up more than 90% of the body's mass? A) O, H, Na B) C, Na, K C) O, Ca, H D) Ca, C, O E) O, C, H

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 6) The organic molecules known as phospholipids are key components of cell membranes and composed of what monomeric units? A) amino acids B) nucleotides C) glycerol D) fatty acids E) both glycerol and fatty acids

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 20) All of these statements about carbohydrates are true except one. Identify the exception. A) Simple sugars include lactose, glucose, and ribose. B) Cellulose is the most abundant carbohydrate on earth. C) Glycogen is a storage polysaccharide made by animal cells. D) Polysaccharides are important both for energy storage and to provide structure to cells. E) Glycogen is important both for energy storage and to provide structure for cells.

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 10) The largest carbohydrate molecules are called polysaccharides because they are composed of ________ molecules bonded together with one another. A) amino acid B) nucleotide C) purine D) pyrimidine E) sugar

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 11) Essential amino acids that are used to build proteins A) exist in twenty six different configurations. B) are linked together by ionic chemical bonds in proteins. C) can be used medically for both diagnosis and treatment of diseases. D) can be derived from the foods we eat and digest. E) can only be made by cells within our bodies.

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 26) Nucleic acids are polymers of units called A) amino acids. B) fatty acids. C) bases. D) ribose. E) nucleotides.

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 46) potassium

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 28) According to the rules of complementary base pairing, a nucleotide containing the base cytosine would only pair with a nucleotide containing the base A) thymine. B) adenine. C) uracil. D) cytosine. E) guanine.

: E Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 16) A free radical is a A) charged particle. B) molecule with an extra electron. C) molecule with an extra neutron. D) molecule with an extra proton. E) molecule with an unpaired electron.

: E Section Title: Molecules and Bonds Learning Outcome: 2.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 18) Atoms in a covalent molecule A) share electrons in single pairs. B) share electrons in double pairs. C) share electrons in triple pairs. D) share electrons singly, never in pairs. E) can share electrons in single pairs, double pairs, or triple pairs.

: E Section Title: Molecules and Bonds Learning Outcome: 2.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 107) The fuel molecule all cells in the body can use is A) sucrose. B) starch. C) protein. D) vitamins. E) glucose.

: E Section Title: Noncovalent Interactions Learning Outcome: 2.1

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 144) 100 mg/dL is a typical blood concentration of glucose. The molecular weight of glucose is approximately 180 daltons. What is the molarity of this solution in millimoles? A) 100 B) 10 C) 0.56 D) 18 E) 5.6

: E Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 145) If in an acid-base reaction H2SO42- donates two H+, one mole of H2SO42- would equal how many equivalents? A) 0.75 B) 1 C) 4 D) 0.5 E) 2

: E Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 2) Which body fluid compartment contains higher levels of Na+, Cl-, and HCO3-? A) plasma only B) interstitial fluid only C) intracellular fluid only D) both plasma and intracellular fluid E) both plasma and interstitial fluid

: E Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 112) Glycoprotein molecules A) act as receptors on the surface of cell membranes. B) function as cell markers. C) are present in the secretions coating the respiratory tract. D) function as hormones from the pancreas. E) act as receptors on the surface of cell membranes and function as cell markers.

: E Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 7) Receptor molecules are located A) only in the outer cell membrane. B) only in the cytosol. C) only in the nucleus. D) only on the cell surface. E) in all of these places.

: E Section Title: Signal Pathways Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 12) Second messenger molecules directly A) change the regulation of ion channels. B) increase intracellular calcium concentration. C) change enzyme activity. D) change regulation of gene expression. E) All of the answers are correct.

: E Section Title: Signal Pathways Learning Outcome: 6.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 14) Diacylglycerol is produced from A) cyclic AMP. B) phospholipase C. C) a G protein. D) protein kinase A. E) phosphatidylinositol bisphosphate.

: E Section Title: Signal Pathways Learning Outcome: 6.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 50) K+ leaves the cell

: E Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 104) If an animal cell lacked centrioles, it would not be able to A) maintain its balance. B) synthesize proteins. C) produce DNA. D) metabolize sugars. E) undergo nuclear division.

: E Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 51) Epithelia are connected to underlying connective tissues by A) a basement membrane only. B) protein filaments embedded in glycoprotein only. C) a basal lamina only. D) a basement membrane and protein filaments embedded in glycoprotein only. E) a basement membrane, protein filaments embedded in glycoprotein, and a basal lamina.

: E Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 59) Functions of connective tissue include A) establishing a structural framework for the body. B) transporting fluids and dissolved materials. C) providing protection for delicate organs. D) storing energy reserves. E) All of the answers are correct.

: E Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 53) Exocrine glands A) may make either mucous or serous secretions. B) release their secretions into the external environment. C) release their secretions through open tubes, called ducts. D) may work as single cells or as a multicellular organ. E) All of the statements are true.

: E Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 78) osteocyte

: E Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 58) Which type of tissue below has minimal extracellular matrix? A) epithelial only B) connective only C) neural only D) muscle only E) epithelial, neural, and muscle

: E Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 62) Plasma is A) found within the circulatory system. B) the fluid portion of blood. C) a subdivision of the ECF. D) sometimes donated instead of blood. E) All of the answers are correct.

: E Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 131) These cells produce a substance and release it, either onto a surface or directly into the blood.

: E Section Title: Tissues of the Body Learning Outcome: 3.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 134) basolateral membrane

: E Section Title: Tissues of the Body Learning Outcome: 3.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 103) Define, compare, and contrast each term listed, and explain how the terms are related to each other: tendons, ligaments, cartilage, bone.

: Each term is a type or subtype of connective tissue. Tendons attach skeletal muscle to bone, whereas ligaments connect bone to bone. Cartilage and bone together are structurally supportive tissues. See Figure 3.12 and 3.13 in the chapter. Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 47) Explain the two forms of down-regulation.

: Either the number of receptors decreases or desensitization in which the binding affinity of the receptors for the ligand decreases. In both cases the result is a lessened response of the target cell even though the concentration of the signal molecule remains high. Section Title: Modulation of Signal Pathways Learning Outcome: 6.6

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 72) Compare and contrast neural and endocrine control.

: See Table 6.2 in the chapter. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 73) Compare and contrast neural, neuroendocrine, and endocrine reflex pathways.

: See Table 6.3 in the chapter. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 119) Consider the two chemical reactions. Identify each statement following as true or false, and clarify as needed. A + B → C C → A + B A. The enzyme catalyzing the formation of C must be different from that catalyzing the breakdown of C. B. The enzyme catalyzing the formation of C must be the same as that catalyzing the breakdown of C. C. Only one of the reactions could occur in a given cell or system. D. Both reactions must be occurring in an equilibrium situation. E. Equilibrium is always achieved in a chemical reaction. F. Equilibrium can be prevented from occurring by constantly removing the product of either reaction. G. An equilibrium, once established, cannot be disturbed.

: A. False. There may be more than one enzyme for the reactions listed, but a given enzyme is often capable of performing a reaction in both directions. B. False. The enzyme for both reactions could be the same, but often a particular enzyme is more likely to perform the forward reaction while a different enzyme is more likely to perform the reverse. C. False. If the reactions are at equilibrium, both are occurring at the same time. If they are not at equilibrium, it is possible that the reaction is occurring only in one direction. In addition, cells can have different enzymes for each reaction direction that can be differentially controlled (i.e., one active and the other inactive). D. True. By definition, a reaction is at equilibrium when both directions are occurring such that there is no net change in amounts of substrates and products. E. False. Equilibrium is not necessarily established, especially in a cell where a product is immediately removed from the system for use elsewhere, such as the product ATP, or if a given enzyme does not perform the reverse reaction. F. True. Any change in amounts of enzyme, substrate, or product will disturb equilibrium, and if these things constantly change, equilibrium cannot be established. G. False. Equilibrium can be disturbed by changing the amount of enzyme, substrate, or product, or by altering the enzyme's efficacy by changing temperature or pH. Section Title: Enzymes Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 128) Red blood cells with an internal osmolarity of 300 mOsM are placed in the following solutions. Designate each solution according to its osmolarity and tonicity, and explain what happens to the cells and why. A. 200 mOsM NaCl B. 400 mOsM urea C. 100 mOsM urea plus 200 mOsM NaCl D. 300 mOsM urea E. 300 mOsM NaCl F. 200 mOsM urea plus 300 mOsM NaCl G. 400 mOsM NaCl

: A. Hyposmotic, hypotonic. The cell swells. By Rule 5 in Table 5.8 in the chapter, hyposmotic solutions are always hypotonic, because the intracellular solutes are mainly nonpenetrating (Rule 1) thus there will be a net flow of water into the cell. B. Hyperosmotic, hypotonic. The cell swells. Urea is a penetrating solute, so some urea will move into the cell down its concentration gradient. This will increase the osmolarity inside the cell, causing a net flow of water into the cell. C. Isosmotic, hypotonic. The cell swells. Urea is a penetrating solute, so there will be a net movement of urea into the cell, raising the osmolarity and causing a net flow of water into the cell. D. Isosmotic, hypotonic. The cell swells. Urea will penetrate the cell, raising the osmolarity and causing a net flow of water into the cell. E. Isosmotic, isotonic. No change in cell size. Sodium and chloride are nonpenetrating solutes, so there will be no net ion flow across the membrane. Because there is no osmotic pressure, there will also be no net flow of water. F. Hyperosmotic, isotonic. No change in cell size at equilibrium. Initially water leaves the cell due to the higher osmolarity outside the cell. Then, because there is a concentration gradient for urea, urea will enter the cell, increasing its osmolarity, and bringing some water into the cell. The nonpenetrating solute concentrations in cell and solution initially are equal, therefore there will be no net movement of water at equilibrium. G. Hyperosmotic, hypertonic. The cell shrinks. There are no penetrating solutes, and water exits due to the higher osmolarity. Section Title: Protein-Mediated Transport Learning Outcome: 5.3

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 159) A. Define stem cells and differentiation, and describe the different types and the extent to which they are present during the life of an individual (include the fertilized egg as well as the adult that eventually results). B. Which of the four tissue types contain populations of stem cells of known function, and what is that function? Which types of tissue have stem cells of unknown function? Do any types of tissue lack stem cells? C. How do fully differentiated cells differ from stem cells? How can stem cells be used in medical treatment? Give examples.

: A. Stem cells are cells that are mitotic and not fully differentiated. Differentiation is the process cells undergo as they become more and more specialized in structure and function as is typical of the specific tissues they compose. The fertilized egg and the cells resulting from the first few cleavage divisions after fertilization are totipotent, which means they can ultimately produce all the types of cells in an adult. Within the first week after conception, the cells begin differentiation and become capable of producing many types of cells but not all. These cells are pluripotent. By adulthood, stem cells can be described as multipotent, which are stem cells that can produce many of the cell types in a specific tissue, and committed stem cells, which can only become one specific cell type within that tissue. B. Epithelial and connective tissues have active populations of multipotent stems cells, which replace cells lost to damage or normal turnover. Muscle and nervous tissues contain stem cells but appear to be unable to replace lost cells. They were once thought to lack stem cells altogether. C. Once cells are fully differentiated, they can no longer divide to produce more cells. Disease conditions or injuries that result in cell loss may be remedied by treatment with appropriate stem cells. Examples are neurological injuries and diseases marked by irreversible damage to cells that cannot (yet) be replaced by new cells. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 147) A. Distinguish between the mass of a molecule and the mass of a mole, using NaCl in your example. B. Calculate the mass of a mole of NaCl in g, using the mass of one Da (amu). C. Calculate the mass of a dozen NaCl molecules, a dozen donuts, and a mole of donuts, assuming a 30 gram donut.

: A. The mass of a molecule is determined by the mass of its component atoms. From the periodic table, the mass of Na is 23 amu and of Cl is nearly 36 amu, so the mass of one molecule of NaCl is 59 Da. A mole is like a dozen, i.e., it is a particular number of items, specifically 6.02 × 1023. B. A mole of NaCl = 59 Da × 6.02 × 1023 = 3.55 × 1025 Da. 1 Da = 1.66 × 10-27 kg, so 3.55 × 1025 Da × 1.66 × 10-27 kg/Da × 1000 g/kg = 59 g. C. A dozen NaCl molecules: 12 × 59 Da × 1.66 × 10-27 kg/Da × 1000 g/kg = 1.2 × 10-21 g. A dozen donuts: 12 × 30 g = 360 g. A mole of donuts: 6.02 × 1023 × 30 g = 1.8 × 1025 g. Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 139) For the following strand of DNA, use the table below to provide: bases for the complementary mRNA and bases for the corresponding tRNA molecules and the associated amino acids. What do you notice about the relationship between the DNA and the anticodons? What do you notice about the genetic code for proline in the peptide? How would the loss of the first G or switching that G to a T affect the structure and function of this protein? DNA: GGC CTA CAA GCC GGA ACA GTT ACC GCG TAA CGA mRNA: tRNA:

: mRNA: CCG GAU GUU CGG CCU UGU CAA UGG CGC AUU GCU tRNA: GGC CUA CAA GCC GGA ACA GUU ACC GCG UAA CGA protein: pro asp val arg pro cys gln trp arg ile ala The DNA triplets and the tRNA anticodons are identical except that U (in tRNA) substitutes for T (in DNA). In this peptide, proline was specified by two different codons, CCG and CCU. 1 base lost: arg met phe gly leu val asn gly ala leu 1 base altered: thr asp val arg pro cys gln trp arg ile ala Loss of a base results in dramatic changes in the protein structure (1 less amino acid and a start codon at the second codon) which means the proteins is unlikely to be functional. However, a single base substitution would have a single amino acid different which make the proteins more likely to be functional although the function may still be altered. Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 99) A molecule of sucrose has a molecular weight of 342 daltons. How many grams of sucrose would be required to make one liter of a 2.5 Molar solution of sucrose?

: 805 grams (per liter). This is calculated by multiplying the amount of sucrose in one liter of a 1 molar solution (342 grams) times the molar concentration (2.5). 342 × 2.5 = 805 grams Section Title: Noncovalent Interactions Learning Outcome: 2.9

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 156) In typical women of reproductive age, the epithelial cells lining the uterus (the endometrium) die and are shed from the body roughly once every month, in the process of menstruation. The triggers in this process include chemical (hormonal) changes and contraction of the blood vessels in the lining. Cell death may be a result of either apoptosis or necrosis. Give the characteristics of each process. Devise an argument for classifying the process of menstruation as an example of apoptosis, and then argue for classifying it as necrosis. Which is correct?

: (Note to instructor: If students have not yet studied the reproductive system, they may not be able to answer the final question, therefore it could be omitted.) Necrosis is cell death as a result of damage from toxins, physical trauma, or lack of oxygen; damaged cells release chemicals that may damage neighboring cells. Apoptosis is programmed cell death, which is an internally regulated process and affects only the cell it occurs within. Menstruation may result from necrosis if the causative factor is changes in blood flow to the endometrium such that the oxygen supply is inadequate. Menstruation may result from apoptosis if it results from hormonal changes that directly kill the cells. While menstruation is a normal event and removes unneeded cells (characteristics of apoptosis), it results directly from the decrease in circulation, causing the cells to die from lack of oxygen; thus it is an example of necrosis. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 154) If immunizations were available to prevent cancer, would you want your children to receive them? Explain. Is it likely that one immunization would prevent all cancers? Explain.

: (Note to instructor: Students will need to have had some background on vaccinations to answer this question.) Answers will vary, but students may want to discuss the possibility of adverse reactions to vaccines due to presence of albumin or mercury, the possibility of vaccines containing live virus to actually cause the disease they are supposed to prevent (as in some forms of the polio vaccine), and other possible negative effects compared to the benefit of avoiding the disease. Appropriately applied statistics can help put the cost:benefit ratio into perspective. For example, if there is a family history of certain cancers, a vaccination may be warranted despite the risks. Because there are many types of cancers and vaccinations are highly specific treatments, one vaccination would not prevent most cancers, but only the type it was designed to prevent. Section Title: Tissue Remodeling Learning Outcome: N/A

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 162) Cell membranes consist of lipid, protein, and carbohydrate in relative amounts that vary according to cell type. Describe the relative proportions of these substances in three structures, and relate these differences to cell function where possible.

: (Note to instructor: This may be a good question to use on a comprehensive final exam, as it ties together basic membrane composition with cell functions revealed in later chapters.) See Table 3.1 in the chapter. Red blood cells have nearly equal amounts of protein and lipid, with a small amount of carbohydrate, in this ratio of protein:lipid:carbohydrate: 49:43:8. Myelin is almost all lipid, followed by protein and carbohydrate in this ratio of lipid:protein:carbohydrate: 79:18:3. In later chapters on the nervous system, it will be seen that this preponderance of lipid results in electrical insulation, which is one of the main functions of myelin. The inner mitochondrial membrane is mostly protein, in this ratio of protein:lipid:carbohydrate: 76:24:0. This reflects the function of this membrane in chemical synthesis that relies on a variety of protein enzymes. Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 87) The combination of fibers and ground substance in supporting connective tissues is known as ________.

: (extracellular) matrix Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 70) At rest, nerve cells have a voltage of ________ mV.

: -70 (Note to instructor: All nerve cells are different, so you may wish to accept a range of similar values instead of insisting on precisely this value.) Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 140) A 70-year-old man weighs 145 pounds and has 48% of his body weight in the form of water. How many liters of water is that?

: 0.48 × × × 1 L = 31.64 L Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 94) How many milliequivalents are represented by a mole of bicarbonate ions (HCO3-)?

: 1000 milliequivalents. This is calculated by taking the equivalent value of the molecule, which equals the molarity of the molecule (1 in this case) times the number of charges the molecule carries (in this case, the minus symbol indicates a charge of negative one, i.e., -1), so 1×1 = 1 equivalent. 1 equivalent = 1000 milliequivalents. Section Title: Noncovalent Interactions Learning Outcome: N/A

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 139) A patient is given an intravenous infusion of glucose solution that has a concentration of 25 grams of glucose per liter. If the infusion is given at a rate of 4 milliliters per minute, what is the mass flow of glucose into the body?

: 25 g glucose/1000 mL solution × 4 mL solution/min = 0.1 g glucose/min Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 61) The Na+-K+-ATPase pumps (this number of) ________ Na+ ions ________ (into/out of) the cell and (this number of) ________ K+ ions ________ (into/out of) the cell.

: 3 Na+, out of, 2 K+, into Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 141) A dehydrated patient needs a saline solution IV in order to be rehydrated. Unfortunately the hospital is poorly stocked with saline solutions. The nurse was asked by the doctor to mix up 1 L of a 0.45% saline solution using NaCl and distilled water. How would she do this? What is the osmolarity of this solution?

: 4.5 g NaCl into 950 mL of distilled water. Adjust the pH if necessary to 7.4, then add more distilled water, up to 1000 mL. × × × = 0.154 osmoles/L Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 86) Describe the distribution of water in the body's fluid compartments.

: 67% is intracellular. 33% is extracellular; of that 75% is in the interstitial fluid and 25% is in the plasma. Section Title: Osmosis and Tonicity Learning Outcome: 5.1

: Level IV: Quantitative Problems (Bloom's Taxonomy: Synthesis) 163) Nutrients undergo the last stages of digestion by enzymes located on the cells of the small intestine; then the nutrients are absorbed by these same cells by way of various membrane transport processes. Adipose cells absorb and store excess food energy in the form of fat. You and the other students in the physiology lab you are taking are doing an analysis of cell membrane composition, on unknown animal tissue samples labeled A and B. All lab groups determined that sample A contained, on average, 81% protein, 18% lipid, and 1% carbohydrate. Sample B contained 85% lipid, 10% protein, and 5% carbohydrate. Sketch a graph of the class data. You now have to make a logical conclusion as to which sample is more likely to be intestine and which is adipose tissue. What do you conclude, and why?

: A bar graph would be appropriate, as in the figure below. The presence of digestive enzymes and membrane transporters in small intestine cells indicate there should be a significant amount of protein present. Adipose cells, on the other hand, are relatively inactive and can passively absorb lipids by way of simple diffusion through the membrane phospholipids. Adipose tissue is expected, therefore, to consist primarily of lipids. Sample A is most likely small intestine, and sample B adipose. Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 122) Explain what a concentration gradient is and how it assists a cell in doing its work.

: A concentration gradient is a difference in concentration of a particular molecule between the cytosol of a cell and the interstitial fluid. A concentration gradient represents potential energy because of the tendency of molecules to diffuse from areas of high to areas of low concentration. Section Title: Energy in Biological Systems Learning Outcome: 4.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 115) Provide the basic physics definition of the term fluid. What is bulk flow relative to body compartments? What types of matter move by bulk flow? What is fundamentally different in the behavior of these types of matter?

: A fluid is a substance that flows. Bulk flow is movement of a fluid, usually within a body compartment. Liquids and gases are fluids, and they flow. Gases are compressible, but liquids are not. Section Title: Transport Processes Learning Outcome: 5.1

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 137) How does the beta cell in the pancreas react to release insulin when glucose levels are low?

: ATP dependent potassium gates keep the insulin releasing channels closed when there is enough glucose getting into the cell. When glucose levels drop and the amount of ATP the beta cell is making drops, it eventually loses the energy to keep the gates closed, therefore opening and allowing insulin to be released into the blood. Section Title: Integrated Membrane Processes: Insulin Secretion Learning Outcome: 5.14

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 92) What are the advantages of using ATP as the energy-transferring molecule in a cell?

: ATP easily acquires the energy stored in complex biomolecules such as carbohydrates and its phosphate bonds are readily broken to release energy. Section Title: Metabolism Learning Outcome: 4.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 71) The activity of metabolic pathways is influenced by the ratio of ________.

: ATP to ADP Section Title: Metabolism Learning Outcome: 4.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 134) Which membrane transport process(es) is/are abnormal in people with cystic fibrosis? What is the consequence of the abnormal transport? Which organ systems are affected? How is this disease treated? How long do cystic fibrosis patients normally live? What are some of the possible causes of death related to this disease? What is the cause of cystic fibrosis?

: Active transport of chloride is impaired, in the airways, sweat glands, and pancreas. The affected epithelia are involved in production of sweat and mucus. Thus the respiratory, integumentary, and digestive systems are affected. Treatments include replacement of pancreatic digestive enzymes, which are blocked from secretion by the mucus buildup in secretory ducts, and respiratory therapies to loosen mucus in the airways and treat recurring infections. Gene therapy is being explored as well. Median survival is 37 years as of the publication date of the textbook. Causes of death can be related to malnutrition and respiratory illness. This is a genetic disease, in which the gene coding for the chloride transporter is abnormal. Section Title: Epithelial Transport Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 100) Define, compare, and contrast each term listed and explain how the terms are related to each other: rough endoplasmic reticulum, smooth endoplasmic reticulum, ribosomes, and Golgi body.

: All are structures involved in synthesis of biomolecules. All but ribosomes are membranous structures. Ribosomes may be free or attached to ER, making it rough. See Figure 3.12 in the chapter. Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 99) Distinguish between these statements, explaining what is correct or incorrect about each, and what requires clarification. Relate your answers to the energy hill concept from the previous chapter. A. Passive transport requires energy. B. Active transport requires energy. C. Vesicular transport requires energy.

: All forms of transport require energy, because something is being moved. A. Passive transport uses the thermal energy present in the living cell to move molecules in the energetically favorable downhill direction (with concentration gradients). B. Active transport uses the energy transferred by the ATP molecule, to move molecules in the energetically unfavorable uphill direction (against concentration gradients). C. Vesicular transport uses the energy of the ATP molecule also, to move large molecules or large quantities of molecules. Section Title: Protein-Mediated Transport Learning Outcome: 5.8

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 157) The most common types of cancer in America include colon cancer, skin cancer, breast cancer, cervical cancer, and prostate cancer. What do all of these cancers have in common and why are they so prevalent in our society?

: All of these structures have epithelial tissue that is reproducing at a rapid rate. Because they undergo mitosis so often if a failure of apoptosis occurs or if a mutation alters the DNA of one of the cells, the new copies of the existing cells will cause an increase in the cancerous cells at a much faster rate than in other tissues that divide at a much slower rate. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 118) Explain how these statements differ, and identify which one(s) is/are correct. Explain what is wrong with each incorrect statement. Explain when chemical reactions continue and when they stop. A. A chemical reaction proceeds until the enzyme molecules are all consumed. B. A chemical reaction proceeds until the substrate molecules are all consumed. C. A chemical reaction proceeds until equilibrium is established. D. A chemical reaction proceeds until all the product molecules are removed.

: B and C are correct as written, but B requires some clarification. A is incorrect because enzyme molecules are not consumed in chemical reactions and will continue to be active until acted upon by environmental conditions (temperature, pH, or modifiers). B is correct only when the product is removed from the system. If the product remains, the enzyme will reach equilibrium where the ratio of substrate to product is constant (Correct Answer C). In D, if the product of the reaction is removed, the reaction would continue to proceed to form new product (assuming enzymes and substrates are available). Chemical reactions continue if conditions are favorable, including presence of substrate and enzyme and fairly constant temperature and pH. In living systems, most chemical reactions do not have a steady supply of substrate; for example, the chemical reactions of digestion will stop when the small intestine is empty. Section Title: Enzymes Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 132) Your swimming buddy Mark jumped into a pool parallel to the water surface. When he stood up, he yelled "ouch" and you noticed that the skin on his chest and belly looked red and irritated. How would you describe the properties of water to explain to Mark why this happened? Why doesn't it hurt when pool water is penetrated perpendicular to the surface, as with a hands-first or feet-first dive?

: Because Mark was parallel to the water surface, the force of his mass was spread out over a relatively large area of the water, making the force per unit water lower than in a typical dive. The surface tension of water, while not strong enough to keep Mark from penetrating the water surface, was strong enough to momentarily resist him. The force of the water pushing back on Mark, however briefly, was enough to cause pain. In a typical dive position, the force of Mark's entire mass is spread only over a tiny area of the water, and thus the force per unit water surface is greater. This higher force is sufficient to immediately break the hydrogen bonds and overcome the surface tension. Section Title: Noncovalent Interactions Learning Outcome: 2.3

: Level III: Problem Solving (Bloom's Taxonomy: Application) 127) When the kidney goes into failure, one of the signs that doctors will see is that red blood cells will crenate (shrivel up). Why does this happen in kidney failure? What process is occurring to the blood cells?

: Because the kidney is failing to filter particles out of the blood effectively, the plasma becomes hypertonic or hyperosmotic in comparison to the intracellular compartment of the blood cell. Since the cell membrane is impermeable to the ions, but permeable to water, water will leave the cell to try to balance the tonicity and osmolarity with the plasma and in the process the cell will shrink. Section Title: Osmosis and Tonicity Learning Outcome: 5.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 98) Compare and contrast facilitated diffusion and active transport.

: Both involve binding of substrate to a carrier, but facilitated is passive, moving solutes down their concentration gradients, whereas active requires ATP and can move solutes against their concentration gradients. Section Title: Protein-Mediated Transport Learning Outcome: 5.8

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 137) Explain how it is possible for an enzyme to catalyze a chemical reaction in two different directions.

: Both the substrate and product have a 3-D shape complementary to the active site of the enzyme. In a synthesis reaction between two organic monomers, the enzyme holds the substrates in a position that greatly increases the likelihood of bond formation between them, and as the bond forms to produce a dimer, the affinity of the enzyme for the substrates increases. The dimer is also complementary to the active site of the enzyme, and if a dimer molecule happens to bind to the enzyme, becoming the substrate, the bond between the monomers becomes strained as the intermediate is formed and can break. If this happens, the reaction is a degradation and the products are the monomers. The tightest binding is between the enzyme and the intermediate form, different in structure compared to either the substrates or the product. Thus it is equally likely that the reaction will be a synthesis or a degradation, if no other factors are considered. Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 101) Compare and contrast primary active transport and secondary active transport, noting any special differences.

: Both ultimately depend on the energy of ATP, but dependence is indirect in secondary, direct in primary. Section Title: Protein-Mediated Transport Learning Outcome: 5.8

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 81) Brain cells are able to absorb glucose independent of insulin. What must be missing from brain cells compared to most other cell types? One of the risks of diabetes mellitus is diabetic coma, which results when insufficient glucose is available to the brain. Would you expect diabetic coma to be triggered when insulin is low or high? Explain. (Hint: Think about regulation of the number of glucose transporters in brain cells and how the hyperglycemia present prior to insulin treatment may affect transporters.)

: Brain cells lack the insulin receptors that stimulate glucose uptake, because an insulin-independent mechanism for glucose uptake is present. Brain cells will down-regulate their glucose transporters during periods of hyperglycemia. When insulin levels increase during treatment of type I diabetes, promoting lower concentrations of glucose in the blood, this can trigger diabetic coma because the brain cells have too few glucose transporters for the new, lower levels of blood glucose. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 7) Cell membranes are said to be A) impermeable. B) freely permeable. C) selectively permeable. D) actively permeable. E) None of the answers are correct.

: C Section Title: Biological Membranes Learning Outcome: 3.2

Human Physiology: An Integrated Approach, 6e (Silverthorn) Chapter 6 Communication, Integration, and Homeostasis 1) Cells that respond to signals are usually called A) responders. B) receivers. C) targets. D) contacts. E) junctions.

: C Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 144) Your study partner is having difficulty understanding dense fibrous connective tissue, tendons, and ligaments. Explain to her how they are related to each other and how they are different from other categories of connective tissue.

: Dense fibrous connective tissue is a category of connective tissue, distinct from loose, adipose, blood, bone, and cartilage. It is not as dense as cartilage and bone but is denser than the other types listed. Like loose connective tissues, fibroblasts are the primary cell type, but unlike loose, the matrix consists of relatively more protein fibers and less ground substance. Like bone and cartilage, the fibers are primarily collagen. The fibers can be arranged randomly (irregular) or parallel to each other (regular). Tendons and ligaments are both composed of dense fibrous connective tissue. Tendons attach muscles to bones, whereas ligaments attach bones to bones; tendons lack elastic fibers, but they are present in ligaments; therefore ligaments are slightly stretchy. Section Title: Tissues of the Body Learning Outcome: 3.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 27) ________ can be caused by alterations in receptors or by problems with G protein or second messenger pathways.

: Diseases Section Title: Modulation of Signal Pathways Learning Outcome: 6.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 105) Explain the term dynamic steady state.

: Dynamic indicates that materials are constantly moving from compartment to compartment, but steady state implies there is no net movement between the compartments. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 6) Which of the following is NOT a function of membrane proteins? A) bind to ligands B) regulate the passage of ions C) act as transport molecules for various solutes D) anchor or stabilize the cell membrane E) produce energy

: E Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 8) What is/are the major role(s) of the phospholipid bilayer? A) the absorption of fats only B) the formation of a barrier that is selectively permeable to lipid-soluble molecules only C) to provide a framework for membrane proteins only D) to carry water-soluble molecules through a hydrophobic environment only E) the formation of a barrier that is selectively permeable to lipid-soluble molecules and to provide a framework for membrane proteins

: E Section Title: Biological Membranes Learning Outcome: 3.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 2) Which is NOT a basic method of cell-to-cell communication? A) cytoplasmic transfer of signals B) contact-dependent signals C) diffused chemical signals D) nerve and blood-transported signals E) mechanical signals

: E Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 81) Which of the following molecules can move across the phospholipid bilayer by simple diffusion? A) lipids B) steroids C) water D) lipids and water E) All of the answers are correct.

: E Section Title: Diffusion Learning Outcome: 5.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 2) The general term that describes energy stored in chemical bonds is A) thermodynamics. B) bioenergetics. C) entropy. D) kinetic energy. E) potential energy.

: E Section Title: Energy in Biological Systems Learning Outcome: 4.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 56) aminase

: E Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 57) deaminase

: E Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 14) Phosphate groups may be transferred from one molecule to another during A) hydrolysis reactions only. B) addition reactions only. C) dehydration reactions only. D) exchange reactions only. E) addition and exchange reactions.

: E Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 21) An enzyme that transfers phosphates from ATP to a substrate molecule is a A) hydrolase. B) lipase. C) transferase. D) ligase. E) kinase.

: E Section Title: Enzymes Learning Outcome: 4.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 58) Both insulin and glucagon are peptide hormones that target liver cells. The response of the target cells to each of these two hormones is opposite. This information implies that A) the two hormones bind to different cell surface receptors. B) one hormone binds to a receptor on the cell membrane and the other to an intracellular receptor. C) each of the two hormones uses a different second messenger. D) both hormones interact with receptors at the cell nucleus. E) the two hormones bind to different receptors and use a different second messenger.

: E Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 18) Which of the following are considered differences between endocrine and neural control systems? A) specificity B) nature of the signal C) speed D) duration of action E) All of the answers are correct.

: E Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 23) continuously monitors its environment for a specific variable

: E Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 29) All of the structures listed below are involved in storage, EXCEPT A) lysosomes. B) peroxisomes. C) secretory vesicles. D) storage vesicles. E) All are involved in cellular storage.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 22) Microtubules A) are composed of tubulin. B) are hollow, filamentous structures. C) form cilia that aid in cell movement. D) are the largest cytoplasmic fibers. E) All of the answers are correct.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 17) Ribosomal RNA is formed by A) the endoplasmic reticulum. B) Golgi complexes. C) lysosomes. D) mitochondria. E) nucleoli.

: E Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 127) Sally Student does not understand the differences between ions, isotopes, and free radicals. Assuming she has learned and understood some basic chemistry, what is the likely source of her confusion? Review the definitions of these terms, then make a table or flow chart to help her sort this out.

: Her confusion may arise from the fact that all of these terms describe a structure that has either gained or lost something. An ion is an atom that has gained or lost one or more electrons and thus bears an electrical charge. Ions form when salts dissolve in water and are required for normal cell function. An ion's charge affects both its behavior in solution and its chemical reactivity. An isotope is an atom that has gained or lost one or more neutrons; as neutrons lack a charge, isotopes remain neutral. Some isotopes emit radiation, a type of energy, rendering them both useful and dangerous; compared to ions, they are rare in nature. A free radical is an atom or molecule that has at least one unpaired electron (an electron is more stable if paired with another electron). Free radicals can be either electrically charged (e.g., superoxide) or neutral (e.g., hydroxy), depending upon the total number of protons and electrons present. Because free radicals are unstable, they are highly reactive and disruptive to cell function; compared to ions, they are rare in the body. Neither isotopes nor free radicals are known to be required for normal cell function. Section Title: Molecules and Bonds Learning Outcome: 2.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 109) What property of some cell membranes is associated with impermeability to water molecules?

: Higher concentrations of cholesterol in the cell membrane reduce membrane permeability to water. Section Title: Protein-Mediated Transport Learning Outcome: 5.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 134) Stanley Student is confused on the similarities and differences between proteins and nucleic acids. Assuming he has learned and understood the basic chemistry, what is the likely source of his confusion? To help him sort this out, make a table or flow chart to explain the structure of these molecules and their relationship to each other.

: His confusion probably stems from the fact that both proteins and nucleic acids are classified as macromolecules, and both are assembled by covalently bonding certain monomers in a particular order. Also, nucleic acids contain the information necessary for manufacturing proteins, the term acid is used in describing the structure of both nucleic acids and proteins, and both nucleic acids and proteins must contain nitrogen. The monomer of protein is the amino acid, which has a central carbon, a variable chain denoted as R, and a nitrogen-containing amino group. There are 20 naturally occurring amino acids. The monomer of the nucleic acid is the nucleotide, which has a sugar attached to a nitrogen-containing base, and a phosphate. There are five different bases and two different sugars. The sequence of bases in a DNA or RNA molecule determines the sequence of amino acids in the protein. Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 155) A vaccine has recently been developed that can prevent infection by the human papillomavirus. This vaccine is available to young girls. What disease could this virus prevent? Why may some parents hesitate to have their daughters receive this vaccine?

: Human papillomavirus (HPV) causes some types of cervical cancer. Because HPV is sexually transmitted, some parents may be reluctant to make it available to their young daughters, preferring instead that their daughters abstain from sexual activity until they are older and/or married. Section Title: Tissue Remodeling Learning Outcome: N/A

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 124) Water striders are insects that literally walk on water. These insects are frequently found living on ponds. If hydrogen bonds did not exist, how would this affect the life of water striders?

: Hydrogen bonds are responsible for the surface tension of water, the attractive force between water molecules that can make it difficult to separate them. The surface tension is strong enough to support the weight of water striders thus allowing them to walk on water. If water molecules could not form hydrogen bonds, the water striders would not be able to walk on water because there would be no surface tension to support their weight. Therefore, these insects would have to adapt to terrestrial conditions near ponds or lakes rather than living on them. Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level IV: Quantitative Problems (Bloom's Taxonomy: Synthesis) 146) Bovine insulin is composed of 30 amino acids. What is the minimum number of DNA triplets in the insulin gene, based on the amino acid length? What is the minimum number of DNA bases in the coding region? Explain how and why the actual number of triplets in the gene may differ.

: Ignoring stop and start codons, RNA splicing, and post-translational modification, a peptide of 30 amino acids is specified by 30 triplets. As a triplet is 3 bases in length, this means a minimum of 90 DNA bases (30 triplets × 3 bases per triplet) is present in the insulin gene. The actual number of triplets and bases is higher, because the gene starts and ends with start and stop sequences, some of the mRNA codons are excised prior to translation and peptide sequence, and furthermore post-translational modification of the peptide may remove additional amino acids. Thus the number of amino acids in the peptide is related to gene length but doesn't allow precise calculation of gene length. Section Title: Metabolism Learning Outcome: 4.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 102) Describe the composition and function of the extracellular matrix.

: In any tissue, the extracellular matrix consists of two basic components: proteoglycans and insoluble proteins. The matrix plays an important role in processes ranging from growth and development to cell death. The matrix aids in cell communication with its environment by attaching to the cell membrane or cytoskeleton. Section Title: Tissues of the Body Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 129) There are two solutions separated by a semipermeable membrane. Solution a is 0.3 M glucose, and solution b is 0.15 M NaCl. Will there be a net flow of water across this membrane? Why or why not?

: In osmoles, solution a is 0.3 OsM and solution b is 0.3 OsM (because sodium and chloride dissociate into separate particles). The solutions are isosmotic, and there is no net water flow. Section Title: Protein-Mediated Transport Learning Outcome: 5.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 98) List the four major tissue types. Give an example and location of each.

: See Table 3.4 and the "Issues of the Body" section in the chapter. Section Title: Tissues of the Body Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 158) Apoptosis and necrosis are described as the two ways cells die. Which one is "messy"? Which is "tidy"? Explain. Why do these forms of cell death exist? What are some advantages and/or disadvantages of each? Use the lining cells of the digestive tract in an example of an advantageous process.

: Necrosis is a result of damage to cells. The cells swell and rupture, and the enzymes that are released cause damage to other cells in the area; hence the descriptor "messy." Necrosis has the disadvantage of damaging cells that might otherwise have survived unscathed. Necrosis is not an advantageous process, but it is unavoidable because trauma to cells is unavoidable; we all get hurt sometimes. Apoptosis is "tidy" in that the cells do not rupture and release damaging enzymes; instead the cell breaks up into membrane-surrounded pieces that are consumed by immune cells. Apoptosis is advantageous in that it can shape a structure such as fingers and toes during development. In the case of the digestive tract, the harsh chemical environment would lead to frequent necrosis if it weren't for the programmed apoptosis occurring every day or so. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 145) Define and distinguish between necrosis and apoptosis, and give specific examples of each.

: Necrosis is cell death as a result of damage from toxins, physical trauma, or lack of oxygen; damaged cells release chemicals that may damage neighboring cells. An example is death of skin cells as a result of sunburn. Apoptosis is programmed cell death, which is an internally regulated process and does not involve neighboring cells unless they too are so programmed. An example is the loss of skin webbing between fingers and toes in a fetus. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 91) ________ is a tissue that is modified to transmit electrical signals from one cell to another.

: Neural tissue / Nervous tissue Section Title: Tissues of the Body Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 67) What are NSAIDs, what is their function, and what are some drawbacks to their use?

: Nonsteroidal anti-inflammatory drugs, such as aspirin and ibuprofen, prevent inflammation. They have side effects such as bleeding in the stomach. Section Title: Novel Signal Molecules Learning Outcome: 6.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 144) Nurse Cameron has been asked to mix an isotonic intravenous solution for an emergency room patient who has lost a lot of blood. The available solutes include glucose (m.w. 180), NaCl (m.w. 58.5), and urea (m.w. 60). How should she make up 10 L of IV solution with an osmolarity of 290 mOsm (isosmotic), making sure that it will also be isotonic?

: Nurse Cameron should make her solution contain only nonpenetrating solutes, i.e., she should use NaCl but not glucose or urea. 10 L (0.290 Osmoles/L) (1 mole NaCl/2 Osmoles) (58.5 g/1 mole NaCl) = 84.8 g NaCl. She should add 84.8 g NaCl to about 9.5 L distilled water, mix until dissolved, adjust the pH if necessary to 7.4, then add more water to a final volume of 10 L. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 78) You are part of a research team designing a robot for competition. Your robot needs to be able to respond to painful stimuli like stepping on broken glass. What type of human control system will you model your robot's after and explain your reasons for choosing it.

: One should choose the nervous system and a simple neural reflex because of its ability to rapidly respond and remove the robot from potential harm. The response will be specific for the region in harm and the robot will get a sense of the intensity of pain via a change in the frequency of signaling. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 121) Based on the facts about chemical equilibria in animal systems, indicate for each summary reaction below if it is reversible or irreversible (don't worry about balancing the reactions). Explain the lack of reversibility. In what kind of system would the reaction(s) you selected as irreversible be reversible? Explain. A. C6H12O6 → CO2 + H2O B. ADP + Pi → ATP C. H2O + CO2 → H2CO3

: Only A is irreversible in animal systems. The products are rapidly removed from the system as soon as they are formed, so they are not recombined. This reaction is reversible in plants, which form and store glucose for food, but also need to use some of the glucose to make ATP. Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 117) Explain how these statements differ, and identify which one(s) is/are correct. Explain what is wrong with each incorrect statement. A. A chemical reaction is at equilibrium when there is no further change in substrates. B. A chemical reaction is at equilibrium when the amounts of substrates and product no longer change. C. A chemical reaction stops when it reaches equilibrium. D. A chemical reaction is at equilibrium when the amount of substrate equals the amount of product.

: Only B is correct as written. A could be corrected by clarifying that it is concentration or amount of substrate that ceases to change; individual molecules can form or break at any given time, but the overall amount will not change because synthesis will be balanced by degradation. C is incorrect because the reactions continue as long as conditions such as presence of catalysts, favorable temperature, and presence of substrates are maintained. As a given enzyme can both synthesize and degrade, both processes will continue even at equilibrium. D is incorrect because at equilibrium there is no net change in amounts, but it is not necessary for concentrations of substrates and products to be the same as each other. Section Title: Enzymes Learning Outcome: 4.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 124) Define osmolarity and tonicity. How are they similar? How are they different?

: Osmolarity refers to the concentration of individual particles in solution. Tonicity refers to the behavior of a cell in a solution. They are similar in that both are related to particles in solution. They are different in that osmolarity depends only on the total concentration of particles in solution, whereas tonicity depends on nature of the particles (i.e., are they penetrating or nonpenetrating) as well as on the concentration of the different particles. Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 111) Explain the five rules for diffusion and the two rules for simple diffusion across a membrane.

: See Table 5.1 in the chapter. Section Title: Osmosis and Tonicity Learning Outcome: 5.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 90) Explain how the body can be in a state of osmotic equilibrium and chemical disequilibrium.

: Osmotic equilibrium occurs because water moves freely between most cells and the extracellular fluid. Water will continue to move across membranes into more highly concentrated compartments until the concentrations (solute/volume) are equal, hence osmotic equilibrium. Osmotic equilibrium does not take into account what particles are present in each compartment, just the total number. The key is that water moves freely but the solutes do not. Na+ and Cl- are more highly concentrated in the ECF while K+ and many anions are more highly concentrated inside the cell. Each ion is in chemical disequilibrium because it is not evenly distributed between the two compartments. Although the compartments are chemically different (chemical disequilibrium), when all solutes in one compartment are compared to all the solutes in another compartment they have the same total concentrations of solutes (are in osmotic equilibrium). Section Title: Osmosis and Tonicity Learning Outcome: 5.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 116) Briefly describe oxidation-reduction reactions. What does it mean for a molecule to be reduced or oxidized? Identify and explain the mnemonic device provided in the text for oxidation and reduction reactions. See if you can make one up yourself.

: Oxidation-reduction reactions occur when electrons are transferred from one molecule to another. The molecule that is oxidized in the reaction loses electrons while the reduced molecule gains electrons. OIL RIG (oxidation is loss, reduction is gain) is the mnemonic provided in the textbook. Section Title: Enzymes Learning Outcome: 4.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 93) Describe the four types of enzymatic reactions.

: Oxidation-reduction reactions transfer electrons or protons between substrates. Hydrolysis-dehydration reactions form or break a chemical bond between organic substrates by removing or adding a water molecule. Transfer reactions (Addition-subtraction-exchange reactions) add, remove, or exchange a functional group (phosphate or amino groups) among the substrates. Ligation reactions join molecules using the energy from an ATP molecule. Section Title: Enzymes Learning Outcome: 4.3

: Level III: Problem Solving (Bloom's Taxonomy: Application) 129) Your roommate is not a science major but is interested in science and asks you to verify a rumor he has heard: it is theoretically possible for two people to walk through each other without causing harm. Confirm or refute what he has heard, and explain.

: People are composed of molecules, which are in turn composed of atoms. Each atom is mostly empty space, because the protons, neutrons, and electrons are extremely tiny, and the electrons are relatively distant from each other and from the nucleus. A scientist acknowledges that there is often a finite probability, however small, that a very unlikely event could happen. If all of each person's subatomic particles were aligned just right, they could move through the other person's empty atomic space. This is so unlikely as to be practically impossible, however. Section Title: Molecules and Bonds Learning Outcome: 2.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 95) ________ proteins attach loosely to other membrane proteins or polar regions of phospholipids.

: Peripheral Section Title: Biological Membranes Learning Outcome: 3.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 143) Give three examples of structures whose formation involves molecular interactions that either increase or decrease contact with water molecules, explaining how they are similar and how they differ from each other. (Hint: They all involve molecules that have both polar and nonpolar portions.)

: Phospholipids have a polar portion that is attracted to water and a nonpolar portion that repels water. The molecules orient in water such that water is excluded from contacting the nonpolar portions. This is seen in: the bilayer arrangement of phospholipids in cell membranes, in which hydrophobic tails are in the middle of the layer; micelles, in which a single layer of phospholipids forms a sphere with the hydrophobic tails in the middle; and liposomes, which are hollow spheres made from phospholipid bilayers that can be filled with water-soluble molecules. Section Title: Biological Membranes Learning Outcome: 3.2

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 130) Define polar covalent, nonpolar covalent, ionic, and hydrogen bonding. Which of these bonds involves more than one molecule? Which of these bonds is/are important in determining the properties of water? Explain.

: Polar covalent bonds occur within a single molecule that shares electrons unequally; i.e., the constantly orbiting electrons spend more time at some locations and less at others. Nonpolar covalent bonds occur within a single molecule that shares electrons equally; i.e., the probability of an electron occupying a particular location is the same at all locations. Ionic bonds occur within a single molecule in which one atom completely loses an electron to another, causing each to develop an opposite charge; it is this electrical attraction that holds the molecule together. Hydrogen bonding occurs between separate molecules that contain polar covalent bonds; where electrons spend more time the molecule is partially negative, and where electrons spend less time the molecule is partially positive. The ends of different molecules are thus electrically attracted to each other. Water is a polar covalent molecule, with the oxygen end being partially negative and attracted to the partially positive hydrogen portions of other water molecules. Hydrogen-bonding between water molecules is responsible for surface tension and the crystalline structure of ice. Section Title: Noncovalent Interactions Learning Outcome: 2.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 133) If someone has a muscle cramp or spasm, a commonly discussed treatment is to consume a banana (or another food high in potassium). Why would this be a possible treatment for muscle cramps or spasms?

: Potassium is a cation that leaves the cell during an action potential or depolarization of a muscle or nerve cell, and the muscle or nerve cell needs to move potassium back into the cell to allow the cell to repolarize and relax. If there is a deficiency in potassium, muscle and nerve cells may take longer to repolarize and therefore relax, so increasing your dietary intake of potassium may help cells repolarize quicker. Section Title: The Resting Membrane Potential Learning Outcome: 5.14

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 90) Compare and contrast potential energy with kinetic energy.

: Potential energy is the energy an object has stored in its position, while kinetic energy is energy associated with a moving object/movement. Section Title: Energy in Biological Systems Learning Outcome: 4.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 146) What is the difference between cell movements in response to outside forces and cell-generated movements (in response to specific cell activity)? (Hint: Do red blood cells move because of RBC activity? What causes cell movements associated with cytokinesis?) Using the index of your text to guide you to relevant sections in other chapters (look up entries for the various cytoskeletal proteins), explain the different types of movements that cells generate.

: Red blood cells and other cells in circulation move because they are suspended in a flowing fluid (blood or lymph); the axon of a nerve cell in the arm will move when the arm moves. Cell-generated movements involve the activity of actin microfilaments, intermediate filaments, microtubules, and myosin thick filaments (in muscle). The processes of chromosome alignment during mitosis/meiosis, cytoplasmic pinching during cytokinesis, beating of cilia and flagella, endocytosis and exocytosis, and muscle contraction are all examples of cell-generated movements. Section Title: Intracellular Compartments Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 133) How is the single-stranded mRNA that leaves the nucleus translated into proteins?

: Ribosomes have two subunits (large and small) that are composed of proteins and rRNA. The small subunits binds to the mRNA followed by the large subunit which sandwiches the mRNA. The tRNA (contains the anticodon and associated amino acid) binds to the complementary mRNA. A second tRNA arrives for the next codon and, via dehydration synthesis, a peptide bond is formed between amino acids, which releases the first tRNA from the mRNA and allows the next tRNA to bind. This process continues until the stop codon is reached. Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 102) Explain the process of secondary active transport and how it uses ATP.

: Secondary active transport uses the energy released from moving one molecule down its concentration gradient to push other molecules against their concentration gradient. ATP is used to create the chemical disequilibrium (or concentration gradient) for the first molecule. Section Title: Protein-Mediated Transport Learning Outcome: 5.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 88) Explain the term resting membrane potential difference.

: See "The Resting Membrane Potential" section of the chapter. Section Title: Epithelial Transport Learning Outcome: 5.12

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 101) Sketch a cell membrane. Label at least three components and briefly explain what each one does.

: See Figure 3.4 and the "Tissues of the Body" section in the chapter. Section Title: Intracellular Compartments Learning Outcome: 3.4

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 140) Create a map that integrates the following terms: alternative splicing, constitutive, interference, mRNA, post-translation modification, regulated, repression, induction, translation, and tRNA. Add terms as needed.

: See Figure 4.18 through 4.21 in the chapter. Section Title: Metabolism Learning Outcome: 4.6

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 141) Draw a graph of the free energy of a molecule as a function of time for an exergonic reaction and endergonic reaction. Label on the graph "activation energy" and "net free energy change." How would these reactions be altered by the presence of an enzyme for this reaction?

: See Figure 4.3 in the chapter. The activation energy would be reduced which would increase the rate of these reactions. Section Title: Enzymes Learning Outcome: 4.2

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 142) Graph the effects of changing pH on enzyme activity. In humans, what is the pH for optimal activity of most enzymes?

: See Figure 4.6 in the chapter. The optimal pH for most enzymes is 7.4. Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 107) Draw a membrane channel protein from two different perspectives, clearly indicating the pore in each.

: See Figure 5.10 in the chapter. Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 108) How is a carrier protein like a ship canal?

: See Figure 5.13 in the chapter. Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 110) Explain the process of receptor-mediated endocytosis and exocytosis.

: See Figure 5.24 in the chapter. Section Title: Vesicular Transport Learning Outcome: 5.10

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 103) Explain the purpose of having both the reversible GLUT transporters as well as the SGLT transporters in the body.

: See Figure 5.26 in the chapter. Section Title: Protein-Mediated Transport Learning Outcome: 5.8

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 125) Explain the steps that occur in a pancreatic beta cell so that insulin is secreted.

: See Figure 5.38b in the chapter. Section Title: Integrated Membrane Processes: Insulin Secretion Learning Outcome: 5.14

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 70) Compare and contrast hormones, neurotransmitters, and neurohormones.

: See Figure 6.1 and the "Long-Distance Communication May Be Electrical or Chemical" section in the chapter. Section Title: Cell-to-Cell Communication Learning Outcome: 6.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 66) Describe or diagram the basic pattern of a biological signal transduction pathway.

: See Figure 6.4 and the "Membrane Proteins Facilitate Signal Transduction" section in the chapter. Section Title: Signal Pathways Learning Outcome: 6.4

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 82) Asthma is a respiratory disorder characterized by construction of airways and mucus production which makes it very difficult to breathe. The constriction of airways, mucus production and altered gene expression in the cells lining the airways of asthmatics is due to increased release of neurotransmitter acetylcholine. Explain how a single molecule can have such a large and diverse effect in a single cell.

: See Figures 6.5, 6.6 and 6.8; signal amplification. Section Title: Signal Pathways Learning Outcome: 6.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) You are walking to school one day when you notice an alien spaceship that has crashed in a nearby field. You and some other physiology students collect samples from the beings inside of the spaceship. First, you collect a liquid sample of what appears to be alien blood so that you can test for the concentration of solutes inside the alien blood cells. You then extract some of these cells, place them in various concentrations of glucose in water, then look at them under the microscope. Below is what happens to the cells when they are placed in various concentrations of glucose: Percent Glucose in Water Condition of Alien Blood Cells 0.02% cells lyse 0.05% cells lyse 0.10% cells lyse 0.12% cells crenate (shrivel up) 0.20% cells crenate Table 5.1 135) Refer to Table 5.1. From cells located in another part of the alien's body, you find that the protein-to-lipid ratio of the cell membrane is about 20% protein, 78% lipid, and 2% carbohydrate. Assuming the aliens use their cells as Earthlings do, and have the same terrestrial physiology, what is the most likely function of these cells?

: Similar to the myelin membrane around nerve cells-good insulators. Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 125) If the dissociation constant of a protein is less than one (Kd < 1), what can you conclude about the affinity of the protein for the ligand?

: Since Kd < 1, you know that [P][L] < [PL]. Therefore, at equilibrium, there is a higher concentration of protein-ligand complex suggesting that the protein has a relatively high binding affinity for the ligand. Section Title: Protein Interactions Learning Outcome: 2.10

: Level III: Problem Solving (Bloom's Taxonomy: Application) 150) What type of epithelium would one expect to compose the alveoli (air sacs) in the lungs? Defend your answer.

: Since gases must diffuse across the alveoli and associated capillaries you would expect to find exchange epithelia, composed of very thin cells (simple squamous epithelium). Thicker types of epithelial cells would slow the process of gas diffusion to and from the blood. Section Title: Tissues of the Body Learning Outcome: 3.8

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 151) During a lab practical, Kevin examines a tissue that is composed of densely packed protein fibers that are running parallel and form a cord. There are few nuclei and no striations, and there is no evidence of other cellular structures. Kevin identifies the tissue as skeletal muscle. Why is Kevin's choice wrong, and what tissue is he probably observing?

: Skeletal muscle tissue is made up of densely packed fibers running in the same direction, but since muscle fibers are composed of cells, they would have many nuclei and mitochondria. Skeletal muscle also has an obvious banding pattern or striations due to the arrangement of the actin and myosin filaments within the cell. Kevin is probably looking at a slide of tendon (dense connective tissue). Section Title: Tissues of the Body Learning Outcome: 3.7

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 160) Stem cell research has become a political topic in the last few decades. Explain why the research is being done, why some cells are favored for this research over others, and what the factors are that cause some people not to support this type of research. Are any alternatives available that are less opposed?

: Stem cell therapy may remedy previously untreatable diseases and conditions such as those involving brain and spinal injury. It has become political because one source of stem cells that are highly desirable for research is those removed from human embryos and fetuses. These cells are less differentiated and therefore more likely to be able to yield the specific types of mature cells desired. Many people opposed to abortions of human pregnancies are opposed to the use of human embryos and fetuses as a source of stem cells because these embryos and fetuses are destroyed in the process. Use of umbilical cord blood from live births is less opposed, though these cells are somewhat limited in the types of cells they can produce and therefore may not be valuable for treating as large a variety of diseases and injuries. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 80) Blood glucose levels are kept fairly steady in healthy people through the action of the hormones insulin and glucagon. Insulin decreases blood glucose by promoting glucose uptake by cells, whereas glucagon increases blood glucose by promoting release of glucose from cells. Describe these hormone actions as simple reflex pathways, identifying the stimulus, integrating center, efferent pathway, and response.

: Stimulus: increased blood glucose. Integrating center: endocrine cell (in pancreas). Efferent pathway: insulin secretion. Response: increased cellular uptake of glucose. Feedback: negative. Stimulus: decreased blood glucose. Integrating center: endocrine cell (in pancreas). Efferent pathway: glucagon secretion. Response: release of glucose from cells. Feedback: negative. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 135) Define substrate and product. Are these definitions relative or absolute, and why?

: Substrates are chemicals that bind to the enzyme and are altered (bonds formed and/or broken), producing a product. A product is the result of enzyme action on substrates. These terms are relative because chemical reactions are reversible. Example: if two monomers bind to the enzyme and form a dimer, the monomers are the substrates and the dimer is the product. If instead the dimer binds to the enzyme and splits to form two monomers, the monomers are the products and the dimer is the substrate. Section Title: Enzymes Learning Outcome: 4.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Analysis) 141) Describe the anatomical and fluid compartments of the body. How do the lumens of hollow organs fit into these classifications? Which fluid-containing cavities are considered to be internal and which are external? Of those that are external, why are they external (give examples)? You may wish to design a flow chart to help answer this.

: The anatomical compartments are the cranial cavity, containing the brain; the thoracic cavity, containing the heart and lungs; and the abdominopelvic cavity, containing organs of the digestive, urinary, and reproductive systems. The fluid compartments are the intracellular fluid (inside the cells) and the extracellular fluid (outside the cells). The extracellular fluids are found in the interstitial fluid between cells and the plasma of the blood, which is in the lumen of the circulatory system. Lumens of hollow organs such as the digestive and urinary tracts are part of the external environment, whereas the intracellular and interstitial fluids are internal. The lumen of the circulatory system is also internal. External lumens are those that open to the outside environment. These openings include the mouth, nostrils, anus, urethral and vaginal orifices. Section Title: Functional Compartments of the Body Learning Outcome: 3.1

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 146) Using NaCl to illustrate, explain atomic mass and molecular mass, and an estimated and true mass of one molecule. Your explanation should include the appropriate measurement unit for each, and why the estimated and true masses are not exactly identical.

: The atomic mass is the actual mass of an atom, expressed in atomic mass units (amu) or daltons (Da), where 1 amu = 1.6 × 10-27 kg. Because most of the mass of an atom is contributed by the protons and neutrons, each of which is about 1 amu, the mass can be estimated by counting the number of these particles. The number of protons and neutrons is roughly equal, so the atomic number can simply be doubled to estimate the atomic mass. From the atomic number (see the periodic table) the estimated atomic mass of sodium is 22 amu and of chloride is 34 amu. The mass of a molecule (usually expressed in Da instead of amu) of NaCl is 22 + 34 = 56 Da. From the periodic table, the true weight of Cl is actually closer to 36 amu and of Na is 23 amu, so the true mass of NaCl is closer to 59 Da. There are two reasons why the estimated and actual are not the same: the mass of protons and neutrons is actually greater than one, and the number of neutrons may be more or less than double the number of protons. Section Title: Noncovalent Interactions Learning Outcome: 2.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 119) Compare/contrast the chemical bonds between adjacent monomers in DNA, and between two strands of DNA.

: The bonds holding monomers together are covalent bonds, between sugar and phosphate molecules. The bonds holding neighboring strands together at the complementary bases are hydrogen bonds. Section Title: Noncovalent Interactions Learning Outcome: 2.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Evaluation) 142) Based on what you know about the characteristics of membrane transport, explain the results shown on the graph. Each mixture consists of equal parts of glucose and fructose at the indicated concentration.

: The cell has two separate membrane transport molecules, one specific for glucose and the other for fructose. The transporters become saturated somewhere between the concentrations of 0.5 mM and 1.0 mM, thus any higher concentration of these sugars produces no further increase in transport. Section Title: Protein-Mediated Transport Learning Outcome: 5.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 46) Compare and contrast the four basic methods of cell-to-cell communication.

: The cells can: 1. transfer signal molecules to adjacent cells through gap junctions 2. use contact-dependent signals, which rely on interactions between cell surface molecules on different cells 3. use locally acting chemicals, called paracrines, autocrines, or neuromodulators 4. use long-distance means, which rely on combinations of electrical and chemical signals Section Title: Cell-to-Cell Communication Learning Outcome: 6.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Application) 99) Describe the structure of the cytoskeleton, and list its functions.

: The cytoskeleton consists of actin microfilaments, intermediate filaments, and microtubules and forms a scaffold throughout the cytoplasm. An interesting feature is that some of the proteins are relatively fixed in position, whereas others can be rapidly assembled or disassembled as necessary. The functions include providing mechanical strength and shape, stabilizing position of organelles, intracellular transport system, functional linkage to other cells and to extracellular space, and cell-generated movements. Section Title: Intracellular Compartments Learning Outcome: 3.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 114) What is the induced-fit model? List the types of bonds involved and classify them as strong or weak.

: The interaction between a protein binding site and a ligand that are in close proximity results in a conformational change of the protein to fit more closely to the ligand. The bonds involved are hydrogen (weak), ionic (strong), and van der Waals (weak). Section Title: Protein Interactions Learning Outcome: 2.8

: Level III: Problem Solving (Bloom's Taxonomy: Application) 148) What is the benefit of having some of the cellular organelles enclosed by a membrane similar to the cell (plasma) membrane?

: The isolation of the internal contents of membrane-bound organelles allows them to manufacture or store secretions, enzymes, or toxins that could adversely affect the cytoplasm in general. Another benefit is the increased efficiency of having specialized enzyme systems concentrated in one place, for example, those necessary for energy production in the mitochondrion. In addition, the membranes themselves serve as "workspace," allowing the anchoring of enzymes or other proteins into a stabilized location. Section Title: Biological Membranes Learning Outcome: 3.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 132) Once the mRNA for a particular gene has been transcribed, how is the mRNA that will be released from the nucleus processed?

: The mRNA that is initially transcribed contains regions that are not part of the protein that will be translated. These noncoding regions of mRNA (introns) are removed from the mRNA by splicing. The mRNA then only contains the coding sequences (exons) that can be released from the nucleus to be translated by the ribosome. Due to alternative splicing, the structure of the protein can be different which leads to isoforms of a protein. Section Title: Metabolism Learning Outcome: 4.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Synthesis) 145) Carbon dioxide and water readily combine to form carbonic acid. The change in pH as the acid dissociates can be demonstrated with an indicator dye that changes color at a particular pH. Following this lab in which the color of the solution was observed to change, one lab group forgot to dump the beakers at the end of the lab period. The next day would you expect the beakers to look the same as they did after being bubbled with CO2? If not, explain in terms of reversible reactions and equilibrium disturbance.

: The next day, the solutions had changed back to their original color (before being bubbled with CO2). The carbon dioxide dissipated over night, driving the reaction back in the reverse direction, because the amount of substrate changed. This caused the pH to increase again, above the level required to maintain the color change. Section Title: Enzymes Learning Outcome: 4.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 91) Explain why the composition of the phospholipid bilayer determines how readily water passes through it.

: The phospholipid bilayer is a fluid mosaic and, depending on the function of the cell, contains various ratios of phospholipids, cholesterol, and proteins. Water molecules slip between the spaces between the fatty acid tails. Membranes with higher levels of cholesterol are less permeable to water because cholesterol fills these spaces. Section Title: Diffusion Learning Outcome: 5.6

: Level III: Problem Solving (Bloom's Taxonomy: Synthesis) 79) The fight-or-flight reaction prepares an animal to respond to a threatening situation, by either fighting or running away. One aspect of this response is changes in blood flow such that the skeletal muscles and heart receive higher blood flow (vessels dilate) while digestive organs receive less (vessels constrict). Which signal molecule(s) is/are involved in this response, and how do they produce these changes in blood vessels? Explain how this example illustrates one or more of the following concepts: multiple ligands for one receptor, multiple receptors for one ligand, agonists and antagonists.

: The signal molecules are norepinephrine and epinephrine. Both of these chemicals bind to the same adrenergic receptors (multiple ligands) and have the same effect on their receptors, so they are agonists. When alpha-adrenergic receptors are activated in digestive organs, blood vessels constrict. When beta-adrenergic receptors are activated in skeletal and cardiac muscles, blood vessels dilate (multiple receptors). Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.7

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 131) Define the term transport maximum and describe a way cells can increase their transport capacity.

: The transport maximum occurs when all carrier binding sites are filled with substrate. At this point adding more substrate will no longer increase the rate of transport. In order to increase the capacity and raise the maximum rate of transport, some cells can increase the number of carrier proteins in the membrane. Section Title: Protein-Mediated Transport Learning Outcome: 5.9

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 62) Insulin increases glucose transport across the cell membrane of an adipocyte but not across the membrane of a liver cell. How can one hormone have two different effects?

: The two types of cells differ either in the receptors on their cell membranes or in the signal transduction that occurs after binding of insulin. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.5

: Level IV: Quantitative Problems (Bloom's Taxonomy: Synthesis) 147) Analysis of a single DNA strand yielded this information on amounts of some nucleotides: 43 units of cytosine and 51 units of adenine. What amounts would you expect of guanine and thymine in that strand? What amounts would you expect of all bases in the complementary strand?

: There is no way to determine the amounts of guanine and thymine in the analyzed strand based on the amounts of cytosine and adenine; the guanine and thymine would have to be determined directly. In the other strand, the amount of guanine equals the amount of cytosine in the analyzed strand, and the amount of thymine equals the amount of adenine in the analyzed strand, because of the way the bases pair to hold the strands together. Once the amounts of guanine and thymine in the first strand are determined, the amounts of cytosine and adenine can be determined in the complementary strand. Section Title: Metabolism Learning Outcome: 4.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 64) What general action is shared by about half of the medical drugs currently in use?

: These drugs act on membrane receptor proteins. Section Title: Signal Pathways Learning Outcome: 6.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 113) Define and describe the role of up-regulation and down-regulation of proteins.

: These terms refer to the net change in the amount of a functional protein present in a cell in response to a signal. Up-regulation is an increase in the amount of the protein, whereas down-regulation is a decrease. Section Title: Protein Interactions Learning Outcome: 2.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 48) In your own words restate and explain Cannon's four postulates for maintaining homeostasis.

: This is discussed in the "Cannon's Postulates Describe Regulated Variables and Control Systems" section of the chapter. Section Title: Homeostatic Reflex Pathways Learning Outcome: 6.8

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 69) Design a flow chart or concept map to summarize the information in the text under the heading "Cell-to-Cell Communication." This chart should make clear the four basic methods of cell-to-cell communication, and the relevance of and distinction between paracrine, autocrine, neurocrine, and cytokine chemicals.

: This is discussed in the "Cell-to-Cell Communication" section in the chapter. Section Title: Cell-to-Cell Communication Learning Outcome: 6.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 104) Compare and contrast penetrating solutes and non-penetrating solutes.

: This is discussed in the "Osmosis and Tonicity" section of the chapter. Section Title: Osmosis and Tonicity Learning Outcome: 5.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 95) Briefly explain the difference between open channels and gated channels.

: This is discussed in the "Protein-Mediated Transport" section of the chapter. Section Title: Protein-Mediated Transport Learning Outcome: 5.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Synthesis) 140) Describe the progression of a fertilized egg, from totipotent cell through pluripotent and multipotent stem cells. How might stem cells be of therapeutic value? What is plasticity?

: This is discussed in the "Tissue Remodeling" section of the chapter. Section Title: Tissue Remodeling Learning Outcome: 3.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 138) Design a concept map for the types of cell junctions and the proteins that compose them.

: This is discussed in the "Tissues of the Body" section of the chapter. Section Title: Tissues of the Body Learning Outcome: 3.6

: Level III: Problem Solving (Bloom's Taxonomy: Evaluation) 149) Sketch a short series of simple columnar epithelial cells. Label each of the three different borders. Briefly explain the different kinds of activities that may go on at each border, and tell how their structures and junctions support these functions.

: This is discussed in the "Tissues of the Body" section of the chapter. Section Title: Tissues of the Body Learning Outcome: 3.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the potential or potential change with the causative circumstances. Assume ion movements are net movements.

s may be used more than once or not at all. A. resting membrane potential B. hyperpolarization C. depolarization D. repolarization E. more than one of the answers 49) Na+ enters the cell Answer: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the type of cell junction with the best description.

s may be used once, more than once, or not at all A. gap junction B. tight junction C. anchoring junction 71) simplest cell-cell junction Answer: A Section Title: Tissues of the Body Learning Outcome: 3.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the terms to changes presented, assuming a resting membrane potential of -70 mV.

s may be used once, more than once, or not at all. A. electrical polarization B. hyperpolarization C. depolarization D. repolarization E. more than one of the answers 43) to -50 mV from resting potential Answer: C Section Title: The Resting Membrane Potential Learning Outcome: 5.11

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) Match the correct subatomic particle with the statement about it.

s may be used once, more than once, or not at all. A. proton(s) B. neutron(s) C. electron(s) 38) An ion has gained or lost ________. Answer: C Section Title: Molecules and Bonds Learning Outcome: 2.2


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