In class quiz 2

A diagnostic laboratory finding in myeloma is

Bence Jones proteins in the urine. Response Feedback: Bence Jones protein in the urine is a common clinical manifestation of plasma cell myeloma. It is also known to accumulate in the kidneys and cause kidney damage. Decreased platelet count is not usually a finding in plasma cell myeloma. IgM is not a factor in plasma cell myeloma. Glucose levels are not directly impacted in plasma cell myeloma.

A commonly ingested substance associated with prolongation of the bleeding time is

aspirin. Response Feedback: Many drugs are associated with prolonged bleeding times. Aspirin is known to alter normal platelet function. Acetaminophen is not associated with prolongation of bleeding time. Tobacco does not interfere with bleeding times. Caffeine does not interfere with bleeding times.

A serious complication of deep vein thrombosis is

pulmonary embolus. Response Feedback: Deep vein thrombosis is treated aggressively, as it is the most frequent source of pulmonary embolus. Deep vein thrombosis is not the cause of a stroke. Hypertensive crisis is unrelated to deep vein thrombosis. Extremity necrosis could result from prolonged arterial occlusion.

The cause of the most common form of anemia is

Iron deficiency Response Feedback: Iron deficiency is the most common nutritional deficiency in the world and the most common cause of anemia. Acute blood loss anemia is the result of trauma or disease processes and is highly treatable. Plasma proteins formed in the liver are an essential factor in regulating blood volume. It is important to determine the underlying cause of the anemia so that treatment and control is effective.

The movement of nutrients and O2 as well as the removal of metabolic wastes occurs in

Capillaries Response Feedback: The aorta propels blood into the arteries, arterioles, and finally the capillary beds. Here the proximity of the capillary endothelium to the other cells of the body facilitates movement of nutrients and O2 into the cells and removal of cellular metabolic wastes. Capillary blood is then collected by venules in order to be returned to the right side of the heart. Arteries deliver blood to the arterioles. Arterioles deliver blood to the capillary bed.

Autologous stem cell transplantation is a procedure in which

stem cells are harvested from the patient and then returned to the same patient. Response Feedback: In autologous transplantation, the stem cells are collected from the patient's own blood and then stored and reinfused in the same patient after chemotherapy and radiation. The use of autologous transplants eliminates the problem of graft-versus-host disease. Transplant from a closely matched donor is known as allogenic transplant. In autologous transplant, stem cells are used from the patient's own blood.

The primary source of erythropoietin is provided by the

Kidney Response Feedback: Erythropoietin is a hormone that is secreted into the bloodstream by the kidney. Bone marrow is not responsible for the production of erythropoietin. Hypoxia from low hemoglobin levels causes a decrease in tissue oxygen tension in the kidney, thereby releasing the hormone erythropoietin. The liver is not associated with erythropoietin production.

Which is a malignant disorder of mature antibody-secreting B lymphocytes or plasma cells?

Multiple myeloma Response Feedback: Multiple myeloma is a malignant disorder of mature antibody-secreting B lymphocytes called plasma cells. Hairy cell leukemia is a B-cell phenotype and is characterized by the presence of peculiar cells with hairlike projections. ALL has 80% malignant transformation of B cells, and the remainder involves T cells. CML is caused by malignant granulocytes.

Renal insufficiency is a common complication of which disease?

Myeloma Response Feedback: Renal insufficiency is seen in approximately 50% of patients with plasma cell myeloma, due to hyperproteinemia, Bence Jones protein, hypercalcemia, and hyperuricemia. Chronic myeloid leukemia is manifested by splenomegaly. Chronic lymphoid leukemia is a disease that affects lymphoid tissues and bone marrow. Malignancy along lymphatic pathways is more typical of Hodgkin disease.

An important mediator of a type I hypersensitivity reaction is

histamine. Response Feedback: Histamine mediates type I hypersensitivity reactions. Complement mediates type II hypersensitivity reactions. Antigen-antibody immune complexes mediate type III hypersensitivity reactions. T cells mediate type IV hypersensitivity reactions.