Blood Bank Missed Questions

Following a major trauma event, a family of four walks into your donor center hoping to donate blood. Which one of the following individuals may donate blood today?

A 22-year-old woman using oral contraceptives.

Which best describes an A1 individual?

A and A1 antigens on RBCs and anti-B antibodies in serum.

All of the following steps should be taken in the IMMEDIATE investigation of a potential hemolytic transfusion reaction EXCEPT for what?

A gram-stain on the patient's plasma.

Which of the following is the most important factor in determining the immediate outcomes of kidney transplants?

ABO compatibility

Which of the following conditions is MOST frequently associated with anti-I?

Cold agglutinin disease

Which procedure used to obtain a fetal blood sample to monitor severity of hemolytic disease of the fetus and newborn (HDFN) can also be used to deliver intrauterine transfusions?

Cordocentesis

Which of the following consequences of severe hemolytic disease of the fetus and newborn (HDFN) is most associated with neonatal death before or shortly after birth?

Cardiac failure

Which one of the following blood components contains the MOST factor VIII concentration per mL?

Cryoprecipitate

Which one of the following blood group systems may show a cell typing change during pregnancy?

Lewis

False negative results may occur with indirect antiglobulin tests as a result of all of the following EXCEPT:

Red blood cells have a positive DAT

Before testing, all cord cells should be thoroughly washed in order to:

Remove Wharton's jelly

How long after collection can a patient's sample be used for compatibility testing?

72 hours

The accepted interval between whole blood donations is:

8 weeks

If the unit is going to be transfused within the collection facility, autologous blood must always be tested for which of the following before transfusion?

ABO, Rh

Antibodies directed against granulocyte antigens have been implicated for all of the following EXCEPT?

Acute hemolytic transfusion reactions

Both hemoglobinuria and hemoglobinemia will be present in what type of reactions?

Acute hemolytic transfusion reactions

The AABB Standards for Blood Banks and Transfusion Services requires a control system for antiglobulin tests interpreted as negative. What is done for this control system?

Adding IgG sensitized red cells.

A 9-year-old male in Alaska presents with hemolysis and hematuria. The patient history reveals that he recently recovered from a flu-like virus. The ABO type is A+, and the DAT reacts at 1+. What blood group antibody should be suspected?

Autoanti-P

A D-positive mother with a D-negative fetus eliminates the possibility of HDFN due to the:

D antigen

What is a characteristic of a person who is weak D?

Demonstrates a reduced number of D antigen sites on the surface of the red cell

The use of the direct antiglobulin test is indicated in all the following EXCEPT:

Detection of alloantibodies in serum

Platelet products will be prepared from a whole blood donation. What must be used to prevent potential contamination of the platelets with skin cells and bacteria?

Diversion pouch

Persons with hemophilia A or hemophilia B that demonstrate inhibitors should be given which of the following products?

Factor VIIa

Which of the following may result in a false negative reaction when performing Rh typing?

Failure to follow manufacturer's directions precisely

An antibody screen utilizing polyethylene glycol (PEG) was performed. Reaction readings of this antibody screen are analyzed after immediate spin and again at 37°C incubation with subsequent centrifugation. How will the centrifugation of the tubes affect the patient's results?

False positives may be seen

What is the principle of the Kleihauer-Betke test?

Fetal cells present in the mother's blood smear contain fetal hemoglobin (Hgb F). When treated with acid the fetal cells are resistant and will stain pink with the counter stain.

Hemolytic anemias are diagnosed by clinical findings and laboratory test results. All of the following are lab values that are relied on to help diagnose hemolytic anemia EXCEPT?

Fibrinogen and C-reactive protein

Many red blood cell (RBC) processes, such as binding, transporting, and releasing oxygen, do NOT require energy. Energy however, is required for cellular viability. How does the RBC obtain most of it's energy?

Glycolytic pathways

A spectrophotometric scan of amniotic fluid may be valuable in the determination of which of the following conditions:

Hemolytic disease of the newborn

Which of the following statements about high-frequency antigens is correct?

High-frequency antigens are common, but it is difficult to identify their corresponding antibodies.

Which of the following antigen groups is closely related to the ABO antigens on the red cell membrane?

I, i

What additional information is required on a label or tie tag of an autologous unit?

Identification of the recipient

The chief purpose of performing a serologic crossmatch is to:

Identify recipient antibodies against donor cells

The immunoglobulin class responsible for the etiology of Hemolytic Disease of the Fetus and Newborn (HDFN) is:

IgG

Which class of immunoglobulins is implicated in hemolytic disease of the fetus and newborn (HDFN)?

IgG

Which of the following activities would require that a label be added to the blood label indicating the name and location of a second manufacturer?

Irradiating a unit of red cells or platelets

What is the rare phenotype found exclusively in male patients that is caused by X-linked inheritance from a carrier mother, often demonstrating a chronic but well-compensated anemia as well as muscle and nerve disorders?

McLeod

All of the following are advantages of performing the computer crossmatch EXCEPT?

One determination of recipient's ABO group is made

Which of the following is the most common type of autoimmune hemolytic anemia?

Paroxysmal cold hemoglobinuria.

What is the deferral period from donating blood for someone who is or has taken Tegison© for severe psoriasis?

Permanent deferral

Why is Rh immune globulin (RhIg) administered within 72 hours of delivery to an Rh negative mother if the newborn is found to be D-positive or weak-D positive?

Prevent fetal cells from initially sensitizing the mother

When giving a whole blood donation to a patient, what consideration must be made in regards to the ABO/Rh compatibility between the recipient and the donor?

The recipient and donor ABO and Rh types must be identical.

One risk associated with patients that require chronic transfusions is:

Transfusion associated graft-versus-host disease (TA-GVHD)

Which of the following can be used to confirm if someone has the Bombay phenotype?

Ulex europaeus