Hematology

The same staining protocol can be used for bone marrow smears as is used for peripheral blood smears. True or False?

False

How is the Mean Cell Volume calculated? a) (hemoglobin/red blood cells) x 10 b) (hemoglobin/ red blood cells) x 100 c) (hematocrit %/ red blood cells) x 10 d) (hematocrit % x hemoglobin) x 100

c) (hematocrit %/ red blood cells) x 10

How does hemophilia A differ from hemophilia B? a) hemophilia A is an inherited disorder and hemophilia B is an acquired disorder b) the symptoms are drastically different c) Factor VIII is deficient in hemophilia A and factor IX deficient in hemophilia B

c) Factor VIII is deficient in hemophilia A and factor IX deficient in hemophilia B

Which of the following is a common clinical symptom that is directly related to thrombocytopenia? a) shortness of breath b) joint pain c) petechiae d) fever

c) petechiae

Which of the following laboratory test results is normal in a patient with classic von Willebrand disease? a) bleeding time b) aPTT c) platelet count d) vWF antigen levels

c) platelet count

Which of the following tests could be used to determine whether an abnormal screening coagulation test result (PT or aPTT) is caused by a factor deficiency or an inhibitor? a) bleeding time b) mixing studies c) fibrin split products (FSP) d) fibrinogen assay

b) mixing studies

Which of the following statements best describes a normal erythrocytes? a) a round, disc- shaped, brick red cell with an area of central pallor b) a round, disc- shaped, brick red cell with a nucleus c) a round, disc-shaped, brick red cell containing myoglobin d) a round, disc-shaped, brick red cell which transports lipids

a) a round, disc- shaped, brick red cell with an area of central pallor

Whichform of hemoglobin cannot be measured using the cyanmethehemoglobin method: a) sulfhemoglobin b) carboxyhemoglobin c) oxyhemoglobin d) hemoglobin

a) sulfhemoglobin

A 68 year old woman presents with pressure under the lower left ribs from a swollen spleen, but is not complaining of any other symptoms. her laboratory data showed the following: HgB = 13.5 g/dL Hct = 40% Platelets = 240 x 10 ^ 9/L WBC count = 46 x 10^9/L Differential: 45% Neutrophils, 2% Lymphocytes, 6% Eosinophils, 2% Basophils, 35% myelocytes, 10% metamyelocytes LAP score: 11 a) leukemoid reaction b) chronic myelogenous leukemia c) acute myelogenous leukemia d) polycythemia vera

b) chronic myelogenous leukemia

Factor VII is part of which coagulation pathway? a) intrinsic b) extrinsic c) common

b) extrinsic

A patient with a history of frequent mild bleeding episodes has the following results: Normal PT Prolonged aPTT corrected by normal plasma during mixing studies Which of the following could be a possible cause of the initial aPTT prolongation? a) factor VII deficiency b) factor IX deficiency c) factor V deficiency d) a circulating inhibitor is present

b) factor IX deficiency

You are working in a hematology lab and the machine flags an outlier result for a 51 year old male. The blood was collected in an EDTA tube for a CBC. The hematocrit of the specimen is high at 60%. Which of the following would you do? a) collect blood again, but use less sodium citrate in the tube b) collect blood in heparin c) report these results d) assume that the specimen was switched with that of a newborn child

c) report these results

A small child has albino characteristics, photophobia, frequent pyogenic infections, and her blood smear shows giant dark granules in her monocytes and granulocytes. What is the probable diagnosis? a) Pelger- huet anomaly b) Alder- Reilly c) Toxic granulation d) Chediak- Hegashi syndrome

d) Chediak- Hegashi syndrome

Thewhite blood cell that can appear atypical a reactive on a Wright- stained smear is: a) Basophil b) Eosinophil c) Neutrophil d) Lymphocyte

d) Lymphocyte

The hematology laboratory is experiencing instrument downtime. The laboratory has a back- up method for hemoglobin and hematorcrit testing that is being used until the instrument is repaired. The hematologist calls and asks if you can provide any of the red blood cell indices. Which of the indices, of any, can you provide for the hematologist? a) MCV and MCH b) MCH and MCHC c) MCH only d) MCHC only e) MCV, MCH, and MCHC

d) MCHC only

Nucleated RBC's are most likely to be seen in the peripheral blood of which of these beta thalassemias? a) beta thalassemia minima b) beta thalassemia minor c) beta thalassemia intermedia d) beta thalassemis major

d) beta thalassemis major

Erythropoietin is produced in: a) bone marrow b) liver c) lymphocytes d) kidneys

d) kidneys