Neuroleptic malignant syndrome (NMS)
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Factors that increase risk
-High doses of high potency drugs -Dehydration -Poor nutrition -Concurrent medical illness
Symptoms
-Rigidity -High fever -Autonomic instability such as unstable blood pressure, diaphoresis, and pallor -Delirium (usually confused & often mute; may fluctuate from agitation to stupor) -Elevated levels of enzymes, particularly creatine phosphokinase
Treatment
Immediate discontinuance of all antipsychotic medications. Supportive medical care to treat dehydration & hyperthermia until the client's physical condition stabilizes.
Occurance
Most often in first 2 weeks of therapy or after an increase of dosage, but can occur at any time.
