Sin alienates us from...
Sin alienates us from others
Adam blames Eve and God for when he ate the forbidden fruit and God got mad, Eve blames the serpent for eating the forbidden fruit.
Sin alienates us from nation to nation
This becomes relavant in the story of the Tower of Babel. We see that different tribes are fighting against one another to bet eachother to get to heaven first. God becomes angered at what is going on. He casts each tribe into different parts of the land and changes each ones language so that they all speak a different language.
Sin alienates us from nature
We see this when Adam and Eve eat the forbidden fruit that God promises to unleash misfortune, severe weather and, disease into the world. God promises to Adam that Adam will have to dig up the soil of the earth and plant his own food. God promises Eve that she will have to bare the hardship of child birth.
Sin alienates God
When Adam and Eve eat the forbidden fruit they the realize that they are naked they are ashamed and they hide from God because they are so ashamed of their naked forms.
Sin alienates us from ourselves
When we sin we are choosing the wrong thing therefore we are weakening our relationship with God and our true selves. When Cain killed Able he separated himself from himself and God.