BME3 Exam Study

glucose oxidase was isolated from

fungus

george walden was the engineer at the Eli Lilly in charge of insulin production and purification. George Walden's major contribution was that:

he invented isoelectric precipitation

the Ames Reflective Meter was one of the first

home based blood glucose meters

james collip discovered that if he injected too much insulin into a rabbit it developed convulsions. This effect is known as

hypoglycemia

diabetes was first described

independently by many different cultures

the fragment of preproinsulin called c-peptide

is essential, people will die within months without it

engineered E. coli bacteria containing recombinant DNA is not dangerous to humans because

it is incapable of surviving outside well controlled laboratory environments

congress passed the animal welfare act of 1966 after an uproar caused by the publication of an article about dog dealers in what magazine?

life

fred banting grew up

on a farm

immediately after his one year of surgical residence at toronto's hospital for sick children, fred banting

opened his own practice to see patients

arnold beckman invented and sold one of the first integrated

pH meters

during the summer of 1921, Fred Banting performed experiments on dogs. In one group of dogs, he tried to cause the dogs to develop diabetes by removing an organ. Which organ did he remove?

pancreas

from the 1920s through the 1960s, insulin used by patients with diabetes came from which sources

pigs and cows

fred banting developed his idea on how to treat diabetes while he was

preparing a lecture for medical students

the label of a prescription drug

summarizes all the scientific information known about the drug

the quantity known as pH measures

the concentration of hydrogen ions in a solution

james collip, at the University of Toronto, developed a method to isolate insulin based upon

the solubility of insulin in alcohol/water mixtures

banting's method of isolating insulin involved a surgical procedure to tie off ducts in the pancreas, waiting several weeks, then removing the pancreas.

this method was used to produce insulin for just a few times

patients enrolled in the Diabetes Control and Complications Trial were randomly assigned to be part of the tight control group or the standard group.

true

an insulin molecule in circulating in your bloodstream consists of

two chains of amino acids linked together by disulfide bonds

fred banting performed his experiments on dogs at

uni of toronto

today, most insulin in produced in a large factory by which types of organisms

yeast or bacteria

the University of Toronto licensed a patent on the production of insulin to Eli Lilly. The agreement allowed Eli Lilly to manufacture and sell insulin. In return, Eli Lilly would give the University of Toronto

5% of Eli Lily's net sales from the insulin

off label prescribing is when

a physician prescribes a drug to treat a condition that was NOT approved by the FDA

axel ullrich was the first person to insert the human insulin gene into a bacteria, or clone the insulin gene. He obtained the human insulin gene that he cloned from

a woman's insulinoma tumor that was surgically removed

fred banting entered medical school

after dropping out of college

severe symptoms of hypoglycemia could be confused with

alcoholic intoxication

a closed loop system for insulin delivery contains

an insulin pump and a continuous blood glucose meter

the birth control drug Nexplanon is usually implanted under the skin of a woman's

arm

a complete lack of vitamin A in a person's diet can lead to

blindness

in 1921, picric acid was used as a

both a common laboratory reagent and an explosive for artillery shells

In 1920 the company Eli Lilly was known for manufacturing

capsules for drugs

the Diabetes Control and Complications Trial monitored this complication that many diabetes patients suffer

damage to the retina's blood vessels

afrezza and exubera are two different insulin delivery systems. These two systems both

deliver insulin through the lungs

which of the following was not a frequent complication from diabetes before the Diabetes Control and Complications Trial

dementia

x-ray crystallography can be used to

determine the 3 dimensional structure of a protein

the order of amino acids in a protein produced by your body is

determined by your DNA

the birth control drug Nexplanon is implanted under the skin. Nexplanon is an example of ________ applied to birth control

drug delivery

around 1920, the amount of glucose in blood could be measured by an electronic meter.

false!

hypoglycemia can be alleviated by injecting insulin.

false!

when insulin is injected under the skin it has an immediate effect, lowering blood sugar levels within a few seconds.

false!

one of the most common problems people who have lived with diabetes for decades have is with their

feet