Medicinal Chemistry Exam 2 Review

1:100 [A-]/[HA]

Aspirin has a pKa of 3.4. What is the ratio of A¯ to HA in the stomach (pH = 1.4)?

acidic

Acid, Neutral, Basic, or Zwitterionic?

2.3

Given the hydrogen ion concentration of a drug molecule as 0.005M, calculate the pH. (Round to 1 decimal place)

can not be determined (neutral molecule)

If the pKa ofthis drug is 8.69 with a pH of 7.4, What is the percent unionized?

Aldehyde

What functional group is formed when a primary alcohol is oxidized?

basic

Acid, Neutral, Basic, or Zwitterionic?

neutral

Acid, Neutral, Basic, or Zwitterionic?

zwitterionic

Acid, Neutral, Basic, or Zwitterionic?

acidic

Acidic, Neutral, Basic, or Zwitterionic?

10000:1 [A-]/[HA]

Aspirin has a pKa of 3.4. What is the ratio of A¯ to HA in the blood (pH = 7.4)?

6.5

Calculate the pH required for Ligma [HA] to be 40% if the pKa is 6.3. (Round to one decimal point)

5

Fifty percent of a weak acid is in an ionized form in a solution with pH of 5.000, what is the pKa value for the weak acid?

0.3

Given the hydrogen ion concentration of a drug molecule as 0.5M, calculate the pH. (Round to 1 decimal place)

Not enough information to solve

If the pKa of this drug is 4.72 with percent ionization of 43%, what is the pH of the drug? (Round to one decimal point)

74.3%

If the pKa of this drug is 8.56 with a hydrogen ion concentration of 8e-9 M, what is the percent ionization? (Round to one decimal point)

basic

What type of drug would be used along with a inorganic acid to produce a inorganic salt?

basic

What type of drug would be used along with a organic acid to produce a organic salt?

acidic

What type of drug would be used along with a organic base to produce a organic salt?

acidic

what type of drug would be used along with a inorganic base to produce a inorganic salt?