Celiac Disease - Pathophysiology and Etiology

Etiology

Intestinal mucosa damaged by immunologic response.

Secondary complications of Celiac

Intestinal ulceration and development of refractory disease, or disease that no longer responds to a gluten free diet.

Celiac is characterized by:

Sensitivity to the gliadin fraction of gluten.

Symptoms

Abdominal pain, bloating, cramps, diarrhea, steatorrhea, anemia, small stature, delayed maturity, tetany, vitamin deficiencies, muscle wasting, rickets.

Celiac Disease

Chronic immune mediated disorder of the small intestine in which the absorption of nutrients, particularly fats, is impaired.

Risk factors

Familial forms of celiac disease, iron-deficiency anemia, osteopenic bone disease, insulin-dependent diabetes, and genetic disorders such as down syndrome and turner syndrome