GN 301 HW 5-7

A test called the ____ Test mixes a chemical, liver extract, and bacteria to determine if the chemical causes mutations.

Ames

A ___ condition exists when the individual has a chromosome composition that is one more than the normal chromosome number for that species.

Aneuploid

A ___ condition exists when the individual has a chromosome number that is not an exact multiple of the haploid chromosome number for that species.

Aneuploid

A ___ condition exists when the individual has a chromosome number that is one less than the normal chromosome number for that species.

Aneuploid

Two parents have a trait. Their son does not have the trait, but their daughter does have the trait. Draw the pedigree on scratch paper and shade in those individuals who have the trait. Which mode(s) of inheritance are consistent with the inheritance pattern of the shaded trait? Select all that apply.

Autosomal Dominant X-Linked Dominant

A defect that is present at birth is called a

Congenital Defect

Responsible for Charcot Marie Tooth Disease

DUPLICATION

One chromosome has the normal gene sequence and the other has an aberration. Determine what type of aberration is present. Assume that the genes are indicated by letters and that the centromere is indicated by a period. A E . G H M T B and A E . G H B

Deletion

Select all of the individuals who are expected to be female based on chromosome composition.

XO, XXX

What is the sex chromosome composition of an individual who has guevedoces?

XY

A man who has an X-linked dominant allele will pass it on to...

all of his daughters

Huntington's Disease often Shows ____since the disorder tends to present earlier and progress more rapidly in later generations.

anticipation

Responsible for Cri du Chat

deletion

The coding strand of the DNA is provided for you. This is in the middle of the coding sequence so you do not need to find a start or stop. The codons are separated for you. What type of mutation is illustrated? Original Sequence: GCC AGC CAC Mutant Sequence: GCC ACC AC

deletion

One chromosome has the normal gene sequence and the other has an aberration. Determine what type of aberration is present. Assume that the genes are indicated by letters and that the centromere is indicated by a period. A C . T G R M and A C . T G R G R M

duplication

A mutation that inserts a base pair into the DNA within a gene resulting in an alteration of the reading frame for protein production is called a ___ mutation.

frameshift

The coding strand of the DNA is provided for you. This is in the middle of the coding sequence so you do not need to find a start or stop. The codons are separated for you. What type of mutation is illustrated? Original Sequence: GCC AGC CAC Mutant Sequence: GCC GAG CCA C

frameshift-insertion

A ___ occurs when the effects of an environmental agent mimic a genetic condition.

Phenocopy

The coding strand of the DNA is provided for you. This is in the middle of the coding sequence so you do not need to find a start or stop. The codons are separated for you. What type of mutation is illustrated? Original Sequence: GCC AGC CAC Mutant Sequence: GAC AGC CAC

Point Mutation

Responsible for Familial Down Syndrome

Robertsonian translocation

One chromosome has the normal gene sequence and the other has an aberration. Determine what type of aberration is present. Assume that the genes are indicated by letters and that the centromere is indicated by a period. A D F G . H K M and A D H . G F K M

inversion

Exposure to radiation is measured in units called _____. These units are abbreviated with as "Sv".

Sieverts

An agent that causes birth defects is called a ___.

Teratogen

Responsible for Turner Syndrome

monosomic

Marfan Syndrome shows ___ because individuals with this disorder have a variety of abnormalities including long limbs, weak connective tissue, and abnormal heart valves.

pleiotropy

A mutation in which one base pair is substituted for another base pair without increasing or decreasing the length of the DNA is called a ___ mutation.

point

In a one year period, the average person in the USA receives a radiation dose of approximately

6.2 mSv

Approximately ___ % of pregnancies spontaneously miscarry.

15

Approximately 1 in ____ live births has a chromosome disorder.

150

Refer to the following cross for these questions: Aa bb Cc Dd Ee x Aa BB cc DD EY How many different gametes can be formed form the individual of genotype AaBBccDDEY? Give your answer as a number Answer How many different genotypes are expected among the progeny of this cross? Give your answer as a number What is the probability that the first child from this cross will be a son that shows all of the dominant characteristics?

4, 48, 3/32

Approximately ____ % of miscarried fetuses have a chromosome disorder.

50

An agent that causes a change in the DNA sequence is called a ____.

Mutagen

The use of alcohol during pregnancy is said to have __ effects since it causes Fetal Alcohol Syndrome.

Teratogenic

Responsible for Burkitt's Lymphoma

reciprocal translocation