Homework 2

Which of these descriptions best matches the functions of platelets?

Adhere to collagen beneath endothelium

_____ involves a cascade of reactions leading to the conversion of fibrinogen to fibrin.

Coagulation

How would removal of calcium ions from a blood sample affect coagulation?

Coagulation would be prevented

Hemophilia is a bleeding disorder in which the blood doesn't clot normally due to the lacking of certain _____.

blood clotting factors

The intrinsic pathway of the blood clotting is due to the damage of _____.

blood vessel

The process of fibrinolysis

dissolves clots

Tissue factor (Factor III) is a factor in the _____ pathway.

extrinsic

The final product of the common pathway of coagulation is _____.

fibrin thread

Which of the following is NOT a mechanism of hemostasis?

fibrinolysis

Some rat poisons contain a toxin that blocks the liver's ability to utilize Vitamin K. Animals that consume this poison would die of

hemorrhage

The cessation of bleeding is specifically called _____.

hemostasis

[More than 1 answer] A digestive disorder that impairs a person's ability to absorb Vitamin K will result in

low levels of prothrombin low levels of fibrin prolonged bleeding

Areas in a vessel wall where large quantities of lipid accumulate are called

plaques

The enzyme that can digest fibrin and dissolve a clot is

plasmin

The clotting factor that initiates the intrinsic pathway of coagulation is released by _____.

platelets

The extrinsic pathway of coagulation is initiated by the

release of tissue factor (Factor III) by damaged endothelium

Most of the protein factors that are required for clotting are synthesized by

the liver

Which of the following vitamins is needed for the formation of clotting factors?

Vitamin K

Which clotting factor(s) initiate the intrinsic pathway of coagulation?

XII

The intrinsic pathway of coagulation is activated by the

activation of Factor XII exposed to collagen

The positive feedback for amplifying the coagulation effect takes place in _____.

common pathway

The common pathway of coagulation begins with the

conversion of Factor X to prothrombinase

The conversion of fibrinogen to fibrin is catalyzed by the enzyme

thrombin