4.8

α' α KM

Which of the following values influences the value of KMapp (select all correct answers

Competitive

Which type of enzyme inhibition reversibly blocks substrate binding to the enzyme?

all of these answers are correct Competitive Uncompetitive Irreversible

Which type of inhibition always decreases v0?

Competitive

Which type of inhibition could be occurring when a reversible EI complex forms?

None of these answers is correct Competitive Irreversible Uncompetitive

Which type of inhibitor causes an apparent increase in Vmax?

Transition state analog

Which type of inhibitor forms bonds with the enzyme functional groups responsible for stabilizing the transition state (select all correct answers)?

Reversible

Which type of inhibitor interacts non-covalently with an enzyme?

Hydrolysis of a phosphate off of a protein

Which type of reaction does a phosphatase catalyze?

Removal of phosphate groups from proteins

A phosphatase has which of the following functions?

Enzyme-inhibitor

Competitive inhibitors involve formation of which of the following complexes?

ES → E + P

Uncompetitive inhibitors block which of the following reaction steps?

Uncompetitive

When substrate A and inhibitor B are mixed with enzyme E, the KM and Vmax of the reaction apparently decrease. Which type of inhibition is occurring?